Literature DB >> 2992560

Plasma melatonin during desmethylimipramine treatment: evidence for changes in noradrenergic transmission.

P J Cowen, A R Green, D G Grahame-Smith, L E Braddock.   

Abstract

Plasma melatonin was used to determine overall beta-adrenergic transmission through pineal neuro-effector junctions during desmethylimipramine (DMI) treatment in 10 normal subjects. Changes in plasma melatonin indicated that an initial increase in noradrenaline (NA) transmission produced by DMI was counteracted by adaptive changes which restored transmission to normal by the third week of treatment. A 'rebound' increase in NA transmission was seen on DMI withdrawal. The results suggest that the adaptive changes which occur in NA synapses during DMI treatment do not, as has been proposed, decrease NA transmission below normal levels, but instead restore homeostasis in the presence of the drug.

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Year:  1985        PMID： 2992560      PMCID： PMC1463888          DOI： 10.1111/j.1365-2125.1985.tb02717.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  24 in total

1.  Electroconvulsive shock treatment decrease beta-adrenergic receptor sensitivity in rat brain.

Authors:  G N Pandey; W J Heinze; B D Brown; J M Davis
Journal:  Nature       Date:  1979-07-19       Impact factor: 49.962

2.  Feedback inhibition of brain noradrenaline neurons by tricyclic antidepressants: alpha-receptor mediation.

Authors:  T H Svensson; T Usdin
Journal:  Science       Date:  1978-12-08       Impact factor: 47.728

3.  Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain.

Authors:  J Vetulani; F Sulser
Journal:  Nature       Date:  1975-10-09       Impact factor: 49.962

4.  Development of beta-adrenergic receptor subsensitivity by antidepressants.

Authors:  S P Banerjee; L S Kung; S J Riggi; S K Chanda
Journal:  Nature       Date:  1977-08-04       Impact factor: 49.962

5.  Beta-adrenergic receptor function in affective illness.

Authors:  G N Pandey; M W Dysken; D L Garver; J M Davis
Journal:  Am J Psychiatry       Date:  1979-05       Impact factor: 18.112

Review 6.  The catecholamine hypothesis of affective disorders: a review of supporting evidence.

Authors:  J J Schildkraut
Journal:  Am J Psychiatry       Date:  1965-11       Impact factor: 18.112

7.  Determination of a dark-induced increase of pineal N-acetyl transferase activity and simultaneous radioimmunoassay of melatonin in pineal, serum and pituitary tissue of the male rat.

Authors:  M Wilkinson; J Arendt; J Bradtke; D de Ziegler
Journal:  J Endocrinol       Date:  1977-02       Impact factor: 4.286

Review 8.  The pineal gland: a neurochemical transducer.

Authors:  J Axelrod
Journal:  Science       Date:  1974-06-28       Impact factor: 47.728

9.  Antidepressant drugs with varying pharmacological profiles alter rat pineal beta adrenergic-mediated function.

Authors:  E Friedman; F D Yocca; T B Cooper
Journal:  J Pharmacol Exp Ther       Date:  1984-03       Impact factor: 4.030

10.  Effects of chronic desipramine treatment on rat brain noradrenergic responses to alpha-adrenergic drugs.

Authors:  B A McMillen; W Warnack; D C German; P A Shore
Journal:  Eur J Pharmacol       Date:  1980-02-08       Impact factor: 4.432
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  5 in total

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Authors:  E Palazidou; A Papadopoulos; A Sitsen; S Stahl; S Checkley
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

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Authors:  Catherine J Harmer; Ronald S Duman; Philip J Cowen
Journal:  Lancet Psychiatry       Date:  2017-01-31       Impact factor: 27.083

3.  Comparison of the effects of acute fluvoxamine and desipramine administration on melatonin and cortisol production in humans.

Authors:  D J Skene; C J Bojkowski; J Arendt
Journal:  Br J Clin Pharmacol       Date:  1994-02       Impact factor: 4.335

4.  Neuroimmune endocrine effects of antidepressants.

Authors:  Marco Antonioli; Joanna Rybka; Livia A Carvalho
Journal:  Neuropsychiatr Dis Treat       Date:  2012-02-07       Impact factor: 2.570

5.  Potency of melatonin in living beings.

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Journal:  Dev Reprod       Date:  2013-09
  5 in total

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