| Literature DB >> 213833 |
Abstract
The use of different receptor blocking agents and single-unit recording techniques indicates that feedback inhibition of brain noradrenaline neurons by tricyclic antidepressants is mediated by presynaptic alpha-receptors. After chronic imipramine treatment, noradrenaline neurons in the locus coeruleus of rat brain remained partly depressed, in agreement with clinical data. They were, however, resistant to further inhibition by imipramine or clonidine.Entities:
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Year: 1978 PMID： 213833 DOI： 10.1126/science.213833
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728