Literature DB >> 2992367

Comparative efficacy and selectivity of some nucleoside analogs against Epstein-Barr virus.

J C Lin, M C Smith, J S Pagano.   

Abstract

The effects of (2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine (FIAC), 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-methyluridine (FMAU), 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouridine (FIAU), (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVdU), and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG or BW B759U) on the replication of Epstein-Barr virus (EBV) in vitro were evaluated and compared with that of acyclovir (ACV). The relative potencies of these drugs, on the basis of anti-EBV activity, were: FIAC = FIAU greater than FMAU greater than DHPG greater than BVdU greater than ACV; on the basis of the therapeutic index they were: BVdU greater than DHPG greater than FIAC greater than ACV greater than FIAU greater than FMAU. Differential inhibition of EBV-associated polypeptides by these drugs was observed.

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Year:  1985        PMID： 2992367      PMCID： PMC180200          DOI： 10.1128/AAC.27.6.971

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  Effect of 12-O-tetradecanoyl-phorbol-13-acetate on the replication of Epstein-Barr virus. I. Characterization of viral DNA.

Authors:  J C Lin; J E Shaw; M C Smith; J S Pagano
Journal:  Virology       Date:  1979-11       Impact factor: 3.616

2.  Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.

Authors:  G B Elion; P A Furman; J A Fyfe; P de Miranda; L Beauchamp; H J Schaeffer
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

3.  Epstein-Barr virus-associated thymidine kinase.

Authors:  S T Chen; J E Estes; E S Huang; J S Pagano
Journal:  J Virol       Date:  1978-04       Impact factor: 5.103

4.  A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.

Authors:  W M Bonner; R A Laskey
Journal:  Eur J Biochem       Date:  1974-07-01

5.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

6.  Epstein-Barr virus polypeptides: effect of inhibition of viral DNA replication on their synthesis.

Authors:  R J Feighny; B E Henry; J S Pagano
Journal:  J Virol       Date:  1981-01       Impact factor: 5.103

7.  Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate.

Authors:  P A Furman; M H St Clair; J A Fyfe; J L Rideout; P M Keller; G B Elion
Journal:  J Virol       Date:  1979-10       Impact factor: 5.103

8.  Prolonged inhibitory effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine against replication of Epstein-Barr virus.

Authors:  J C Lin; M C Smith; J S Pagano
Journal:  J Virol       Date:  1984-04       Impact factor: 5.103

9.  Metabolism of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, a new anti-herpes virus compound, in herpes simplex virus-infected cells.

Authors:  Y C Cheng; S P Grill; G E Dutschman; K Nakayama; K F Bastow
Journal:  J Biol Chem       Date:  1983-10-25       Impact factor: 5.157

10.  Epstein-Barr virus: inhibition of replication by three new drugs.

Authors:  J C Lin; M C Smith; Y C Cheng; J S Pagano
Journal:  Science       Date:  1983-08-05       Impact factor: 47.728
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  13 in total

1.  Characterization of the Epstein-Barr virus-encoded thymidine kinase expressed in heterologous eucaryotic and procaryotic systems.

Authors:  E Littler; J R Arrand
Journal:  J Virol       Date:  1988-10       Impact factor: 5.103

Review 2.  Approved Antiviral Drugs over the Past 50 Years.

Authors:  Erik De Clercq; Guangdi Li
Journal:  Clin Microbiol Rev       Date:  2016-07       Impact factor: 26.132

3.  Substrate specificity of Epstein-Barr virus thymidine kinase.

Authors:  P P Tung; W C Summers
Journal:  Antimicrob Agents Chemother       Date:  1994-09       Impact factor: 5.191

4.  Metabolic activation of 9([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human lymphoblastoid cell lines infected with Epstein-Barr virus.

Authors:  J C Lin; D J Nelson; C U Lambe; E I Choi
Journal:  J Virol       Date:  1986-11       Impact factor: 5.103

5.  Comparison of two bromovinyl nucleoside analogs, 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil and E-5-(2-bromovinyl)-2'-deoxyuridine, with acyclovir in inhibition of Epstein-Barr virus replication.

Authors:  J C Lin; H Machida
Journal:  Antimicrob Agents Chemother       Date:  1988-07       Impact factor: 5.191

Review 6.  Ganciclovir. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infections.

Authors:  D Faulds; R C Heel
Journal:  Drugs       Date:  1990-04       Impact factor: 9.546

7.  In vitro activity of cefmetazole, cefotetan, amoxicillin-clavulanic acid, and other antimicrobial agents against anaerobic bacteria from endometrial cultures of women with pelvic infections.

Authors:  M J Ohm-Smith; R L Sweet
Journal:  Antimicrob Agents Chemother       Date:  1987-09       Impact factor: 5.191

8.  Potent inhibition of Epstein-Barr virus by phosphorothioate oligodeoxynucleotides without sequence specification.

Authors:  G Q Yao; S Grill; W Egan; Y C Cheng
Journal:  Antimicrob Agents Chemother       Date:  1993-07       Impact factor: 5.191

9.  Identification and functional characterization of Epstein-Barr virus DNA polymerase by in vitro transcription-translation of a cloned gene.

Authors:  J C Lin; N D Sista; F Besençon; J Kamine; J S Pagano
Journal:  J Virol       Date:  1991-05       Impact factor: 5.103

10.  Anti-human immunodeficiency virus agent 3'-azido-3'-deoxythymidine inhibits replication of Epstein-Barr virus.

Authors:  J C Lin; Z X Zhang; M C Smith; K Biron; J S Pagano
Journal:  Antimicrob Agents Chemother       Date:  1988-02       Impact factor: 5.191
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