Literature DB >> 29921889

Positron emission tomography of type 2 cannabinoid receptors for detecting inflammation in the central nervous system.

Ruiqing Ni1, Linjing Mu2,3, Simon Ametamey2.   

Abstract

Cannabinoid receptor CB2 (CB2R) is upregulated on activated microglia and astrocytes in the brain under inflammatory conditions and plays important roles in many neurological diseases, such as Alzheimer's disease, amyotrophic lateral sclerosis, and ischemic stroke. The advent of positron emission tomography (PET) using CB2R radiotracers has enabled the visualization of CB2R distribution in vivo in animal models of central nervous system inflammation, however translation to humans has been less successful. Several novel CB2R radiotracers have been developed and evaluated to quantify microglial activation. In this review, we summarize the recent preclinical and clinical imaging results of CB2R PET tracers and discuss the prospects of CB2R imaging using PET.

Entities:  

Keywords:  cannabinoid receptor CB2; inflammation; microglia; neurological diseases; positron emission tomography

Mesh：

Substances：

Year:  2018        PMID： 29921889      PMCID： PMC6460366          DOI： 10.1038/s41401-018-0035-5

Source DB:  PubMed          Journal:  Acta Pharmacol Sin        ISSN： 1671-4083            Impact factor:   6.150


  78 in total

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Authors:  Manuel B Graeber; Wei Li; Michael L Rodriguez
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