Literature DB >> 2991577

Deletion of the gag region from FBR murine osteosarcoma virus does not affect its enhanced transforming activity.

A D Miller, I M Verma, T Curran.   

Abstract

Both FBJ murine osteosarcoma virus (FBJ-MSV) and FBR-MSV induce transformation in tissue culture and osteogenic sarcomas in mice. In tissue culture, however, FBR-MSV induces larger foci with a shorter latency than those induced by FBJ-MSV. Transformation is dependent on expression of the fos oncogene in FBJ-MSV and of a gag-fos fusion protein in FBR-MSV. We have determined that the gag sequences can be deleted from FBR-MSV without affecting the high transforming activity of this virus in comparison to FBJ-MSV. The resultant virus, designated FBJ/R-MSV, has a protein coding region that is half the size of that of FBR-MSV and about one-third smaller than that of FBJ-MSV. Thus, FBJ/R-MSV will provide a useful tool for studying the transforming activity of the fos oncogene.

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Year:  1985        PMID： 2991577      PMCID： PMC254997     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  21 in total

1.  Two base changes restore infectivity to a noninfectious molecular clone of Moloney murine leukemia virus (pMLV-1).

Authors:  A D Miller; I M Verma
Journal:  J Virol       Date:  1984-01       Impact factor: 5.103

2.  Identification of a 39,000-dalton protein in cells transformed by the FBJ murine osteosarcoma virus.

Authors:  T Curran; N M Teich
Journal:  Virology       Date:  1982-01-15       Impact factor: 3.616

3.  Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.

Authors:  M Kozak
Journal:  Nucleic Acids Res       Date:  1984-01-25       Impact factor: 16.971

4.  Enhancing the efficiency of DNA-mediated gene transfer in mammalian cells.

Authors:  C M Corsaro; M L Pearson
Journal:  Somatic Cell Genet       Date:  1981-09

5.  FBJ murine osteosarcoma virus: identification and molecular cloning of biologically active proviral DNA.

Authors:  T Curran; G Peters; C Van Beveren; N M Teich; I M Verma
Journal:  J Virol       Date:  1982-11       Impact factor: 5.103

6.  A fps gene without gag gene sequences transforms cells in culture and induces tumors in chickens.

Authors:  D A Foster; H Hanafusa
Journal:  J Virol       Date:  1983-12       Impact factor: 5.103

7.  c-fos protein can induce cellular transformation: a novel mechanism of activation of a cellular oncogene.

Authors:  A D Miller; T Curran; I M Verma
Journal:  Cell       Date:  1984-01       Impact factor: 41.582

8.  Sequences of the A-MuLV protein needed for fibroblast and lymphoid cell transformation.

Authors:  R Prywes; J G Foulkes; N Rosenberg; D Baltimore
Journal:  Cell       Date:  1983-09       Impact factor: 41.582

9.  Viral and cellular fos proteins: a comparative analysis.

Authors:  T Curran; A D Miller; L Zokas; I M Verma
Journal:  Cell       Date:  1984-02       Impact factor: 41.582

10.  Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini.

Authors:  C Van Beveren; F van Straaten; T Curran; R Müller; I M Verma
Journal:  Cell       Date:  1983-04       Impact factor: 41.582
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  8 in total

1.  The amino-terminal domain of the v-fms oncogene product includes a functional signal peptide that directs synthesis of a transforming glycoprotein in the absence of feline leukemia virus gag sequences.

Authors:  E F Wheeler; M F Roussel; A Hampe; M H Walker; V A Fried; A T Look; C W Rettenmier; C J Sherr
Journal:  J Virol       Date:  1986-08       Impact factor: 5.103

2.  Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation.

Authors:  S K Rai; F M Duh; V Vigdorovich; A Danilkovitch-Miagkova; M I Lerman; A D Miller
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-10       Impact factor: 11.205

3.  Role of gag sequence in the biochemical properties and transforming activity of the avian sarcoma virus UR2-encoded gag-ros fusion protein.

Authors:  S M Jong; L H Wang
Journal:  J Virol       Date:  1990-12       Impact factor: 5.103

4.  Role of virus receptor Hyal2 in oncogenic transformation of rodent fibroblasts by sheep betaretrovirus env proteins.

Authors:  Shan-Lu Liu; Fuh-Mei Duh; Michael I Lerman; A Dusty Miller
Journal:  J Virol       Date:  2003-03       Impact factor: 5.103

5.  Mechanism of cell entry and transformation by enzootic nasal tumor virus.

Authors:  Clarissa Dirks; Fuh-Mei Duh; Sharath K Rai; Michael I Lerman; A Dusty Miller
Journal:  J Virol       Date:  2002-03       Impact factor: 5.103

6.  Characterization of the transforming domain of a feline sarcoma virus encoding a fgr-related tyrosine kinase.

Authors:  G Weyrauch; A Barnekow
Journal:  Arch Virol       Date:  1994       Impact factor: 2.574

7.  Invasion of normal human fibroblasts induced by v-Fos is independent of proliferation, immortalization, and the tumor suppressors p16INK4a and p53.

Authors:  Linda A Scott; J Keith Vass; E Kenneth Parkinson; David A F Gillespie; Joseph N Winnie; Bradford W Ozanne
Journal:  Mol Cell Biol       Date:  2004-02       Impact factor: 4.272

8.  Putative phosphatidylinositol 3-kinase (PI3K) binding motifs in ovine betaretrovirus Env proteins are not essential for rodent fibroblast transformation and PI3K/Akt activation.

Authors:  Shan-Lu Liu; Michael I Lerman; A Dusty Miller
Journal:  J Virol       Date:  2003-07       Impact factor: 5.103
  8 in total

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