Literature DB >> 8279950

Characterization of the transforming domain of a feline sarcoma virus encoding a fgr-related tyrosine kinase.

G Weyrauch1, A Barnekow.   

Abstract

We investigated the transforming domain of a recently isolated feline sarcoma virus (TP1-FeSV) which encodes a fgr-related tyrosine kinase expressed as a gag-fgr fusion protein. The gag portion was removed and replication-competent expression vectors (RCAS) with inserted v-fgr sequences were established. Chicken embryo fibroblasts (CEF) were transfected and monitored for replication, integration and transcription of the proviral constructs. We demonstrated that transfected cells display morphological changes and are able to form colonies in soft-agar. This suggests that the gag portion of the fusion protein from TP1-FeSV is not necessary for the transformation of fibroblasts.

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Year:  1994        PMID： 8279950     DOI： 10.1007/bf01379113

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  32 in total

1.  Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity.

Authors:  A Golden; S P Nemeth; J S Brugge
Journal:  Proc Natl Acad Sci U S A       Date:  1986-02       Impact factor: 11.205

2.  Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase.

Authors:  U Holtrich; A Bräuninger; K Strebhardt; H Rübsamen-Waigmann
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-01       Impact factor: 11.205

3.  Differential expression and regulation of the c-src and c-fgr protooncogenes in myelomonocytic cells.

Authors:  C L Willman; C C Stewart; J K Griffith; S J Stewart; T B Tomasi
Journal:  Proc Natl Acad Sci U S A       Date:  1987-07       Impact factor: 11.205

4.  Origin and biological properties of a new feline sarcoma virus.

Authors:  S Rasheed; M Barbacid; S Aaronson; M B Gardner
Journal:  Virology       Date:  1982-02       Impact factor: 3.616

5.  Protein stabilization explains the gag requirement for transformation of lymphoid cells by Abelson murine leukemia virus.

Authors:  R Prywes; J Hoag; N Rosenberg; D Baltimore
Journal:  J Virol       Date:  1985-04       Impact factor: 5.103

6.  Tissue-specific expression and developmental regulation of the human fgr proto-oncogene.

Authors:  T J Ley; N L Connolly; S Katamine; M S Cheah; R M Senior; K C Robbins
Journal:  Mol Cell Biol       Date:  1989-01       Impact factor: 4.272

7.  The ovalbumin gene family: hormonal control of X and Y gene transcription and mRNA accumulation.

Authors:  M LeMeur; N Glanville; J L Mandel; P Gerlinger; R Palmiter; P Chambon
Journal:  Cell       Date:  1981-02       Impact factor: 41.582

8.  Molecular cloning of integrated Gardner-Rasheed feline sarcoma virus: genetic structure of its cell-derived sequence differs from that of other tyrosine kinase-coding onc genes.

Authors:  G Naharro; S R Tronick; S Rasheed; M B Gardner; S A Aaronson; K C Robbins
Journal:  J Virol       Date:  1983-09       Impact factor: 5.103

9.  Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.

Authors:  C Auffray; F Rougeon
Journal:  Eur J Biochem       Date:  1980-06

10.  Biological and biochemical characterization of a new isolate of feline sarcoma virus: Theilen-Pedersen (TP1-FeSV).

Authors:  A Ziemiecki; D Hennig; L Gardner; F J Ferdinand; R R Friis; H Bauer; N C Pedersen; L Johnson; G H Theilen
Journal:  Virology       Date:  1984-10-30       Impact factor: 3.616
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