| Literature DB >> 29915235 |
Vincent Wiebach1, Andi Mainz1, Mary-Ann J Siegert1, Natalia A Jungmann1, Guillaume Lesquame2, Sophie Tirat3, Assia Dreux-Zigha2, Jozsef Aszodi2, Dominique Le Beller2, Roderich D Süssmuth4.
Abstract
The potent antibacterial lanthipeptide microvionin, isolated from a culture of Microbacterium arborescens, exhibits a new triamino-dicarboxylic acid moiety, termed avionin, and an unprecedented N-terminal guanidino fatty acid. We identified the corresponding biosynthetic gene cluster and reconstituted central steps of avionin biosynthesis in vitro. Genome mining and isolation of nocavionin from Nocardia terpenica revealed a widespread distribution of this lanthipeptide class, termed lipolanthines, which may be useful as future antimicrobial drugs.Entities:
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Year: 2018 PMID： 29915235 DOI： 10.1038/s41589-018-0068-6
Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040