Tobacco product initiation is correlated with cross-product changes in tobacco harm perception and susceptibility: Longitudinal analysis of the Population Assessment of Tobacco and Health youth cohort.

Youth initiation with one tobacco product is associated with risk of using additional tobacco types. How use of one product potentially encourages use of others could result from changing tobacco-related perceptions. This study aimed to evaluate how tobacco product initiation correlates with changes in susceptibility (curiosity and willingness) and perceived harm of other tobacco products. For each of cigarettes, e-cigarettes, hookah, and smokeless tobacco, youth (ages 12-16; N = 8005) rated perceived harm, curiosity, and willingness to try in Waves 1 and 2 of the Population Assessment of Tobacco and Health (United States, 2013-2015). For each product, we estimated associations between decreased harm rating, increased curiosity, or increased willingness with initiation (from never- to ever-use) of cigarettes, e-cigarettes, hookah, smokeless tobacco, or other combustible products using multivariate (multiple outcomes) regression, adjusting for other tobacco risk factors. Tobacco product initiation was associated with decreased perceived harm for that product and with decreased perceived harm, increased curiosity, and increased willingness in some, but not all, cross-product combinations. Most cross-product combinations of initiation and susceptibility yielded positive associations. For example, trying e-cigarettes was associated with concomitant increases in curiosity about cigarettes (OR: 5.69; 95% CI: 3.68, 8.79) and hookah (OR: 4.19; 95% CI: 2.55, 6.88) and with increased willingness to try cigarettes (OR: 9.61; 95% CI: 5.67, 16.3), hookah (OR: 8.46; 95% CI: 4.76, 15.0), and smokeless tobacco (OR: 3.48; 95% CI: 1.75, 6.94). New use of one tobacco product may catalyze subsequent use of others through cross-product changes in perceptions and susceptibility.