Literature DB >> 29912352

Gut Microbial-Related Choline Metabolite Trimethylamine-N-Oxide Is Associated With Progression of Carotid Artery Atherosclerosis in HIV Infection.

Zhilei Shan1,2, Clary B Clish3, Simin Hua4, Justin M Scott3, David B Hanna4, Robert D Burk4, Sabina A Haberlen5, Sanjiv J Shah6, Joseph B Margolick7, Cynthia L Sears8, Wendy S Post5,8, Alan L Landay9, Jason M Lazar10, Howard N Hodis11, Kathryn Anastos4, Robert C Kaplan4,12, Qibin Qi4.   

Abstract

We examined associations of 5 plasma choline metabolites with carotid plaque among 520 HIV-infected and 217 HIV-uninfected participants (112 incident plaque cases) over 7 years. After multivariable adjustment, higher gut microbiota-related metabolite trimethylamine-N-oxide (TMAO) was associated with an increased risk of carotid plaque in HIV-infected participants (risk ratio = 1.25 per standard deviation increment; 95% confidence interval, 1.05-1.50; P = .01). TMAO was positively correlated with biomarkers of monocyte activation and inflammation (sCD14, sCD163). Further adjustment for these biomarkers attenuated the association between TMAO and carotid plaque (P = .08). Among HIV-infected individuals, plasma TMAO was associated with carotid atherosclerosis progression, partially through immune activation and inflammation.

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Year:  2018        PMID： 29912352      PMCID： PMC6151074          DOI： 10.1093/infdis/jiy356

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  15 in total

1.  HIV status, burden of comorbid disease, and biomarkers of inflammation, altered coagulation, and monocyte activation.

Authors:  Kaku A Armah; Kathleen McGinnis; Jason Baker; Cynthia Gibert; Adeel A Butt; Kendall J Bryant; Matthew Goetz; Russell Tracy; Krisann K Oursler; David Rimland; Kristina Crothers; Maria Rodriguez-Barradas; Steve Crystal; Adam Gordon; Kevin Kraemer; Sheldon Brown; Mariana Gerschenson; David A Leaf; Steven G Deeks; Charles Rinaldo; Lewis H Kuller; Amy Justice; Matthew Freiberg
Journal:  Clin Infect Dis       Date:  2012-04-24       Impact factor: 9.079

2.  HIV Infection Is Associated With Progression of Subclinical Carotid Atherosclerosis.

Authors:  David B Hanna; Wendy S Post; Jennifer A Deal; Howard N Hodis; Lisa P Jacobson; Wendy J Mack; Kathryn Anastos; Stephen J Gange; Alan L Landay; Jason M Lazar; Frank J Palella; Phyllis C Tien; Mallory D Witt; Xiaonan Xue; Mary A Young; Robert C Kaplan; Lawrence A Kingsley
Journal:  Clin Infect Dis       Date:  2015-04-22       Impact factor: 9.079

3.  Soluble CD163, a novel marker of activated macrophages, is elevated and associated with noncalcified coronary plaque in HIV-infected patients.

Authors:  Tricia H Burdo; Janet Lo; Suhny Abbara; Jeffrey Wei; Michelle E DeLelys; Fred Preffer; Eric S Rosenberg; Kenneth C Williams; Steven Grinspoon
Journal:  J Infect Dis       Date:  2011-10-15       Impact factor: 5.226

4.  Choline and its metabolites are differently associated with cardiometabolic risk factors, history of cardiovascular disease, and MRI-documented cerebrovascular disease in older adults.

Authors:  Annie J Roe; Shucha Zhang; Rafeeque A Bhadelia; Elizabeth J Johnson; Alice H Lichtenstein; Gail T Rogers; Irwin H Rosenberg; Caren E Smith; Steven H Zeisel; Tammy M Scott
Journal:  Am J Clin Nutr       Date:  2017-03-29       Impact factor: 7.045

Review 5.  Choline: an essential nutrient for public health.

Authors:  Steven H Zeisel; Kerry-Ann da Costa
Journal:  Nutr Rev       Date:  2009-11       Impact factor: 7.110

6.  Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.

Authors:  W H Wilson Tang; Zeneng Wang; Bruce S Levison; Robert A Koeth; Earl B Britt; Xiaoming Fu; Yuping Wu; Stanley L Hazen
Journal:  N Engl J Med       Date:  2013-04-25       Impact factor: 91.245

7.  Microbiota-Dependent Marker TMAO Is Elevated in Silent Ischemia but Is Not Associated With First-Time Myocardial Infarction in HIV Infection.

Authors:  Judith M Haissman; Andreas Knudsen; Hedda Hoel; Andreas Kjær; Ulrik S Kristoffersen; Rolf K Berge; Terese L Katzenstein; Asbjørn Svardal; Thor Ueland; Pål Aukrust; Anne-Mette Lebech; Susanne D Nielsen; Marius Trøseid
Journal:  J Acquir Immune Defic Syndr       Date:  2016-02-01       Impact factor: 3.731

8.  Plasma Tryptophan-Kynurenine Metabolites Are Altered in Human Immunodeficiency Virus Infection and Associated With Progression of Carotid Artery Atherosclerosis.

Authors:  Qibin Qi; Simin Hua; Clary B Clish; Justin M Scott; David B Hanna; Tao Wang; Sabina A Haberlen; Sanjiv J Shah; Marshall J Glesby; Jason M Lazar; Robert D Burk; Howard N Hodis; Alan L Landay; Wendy S Post; Kathryn Anastos; Robert C Kaplan
Journal:  Clin Infect Dis       Date:  2018-07-02       Impact factor: 9.079

9.  Brief Report: Intestinal Microbiota-Produced Trimethylamine-N-Oxide and Its Association With Coronary Stenosis and HIV Serostatus.

Authors:  P Elliott Miller; Sabina A Haberlen; Todd T Brown; Joseph B Margolick; Joseph A DiDonato; Stanley L Hazen; Mallory D Witt; Lawrence A Kingsley; Frank J Palella; Matthew Budoff; Lisa P Jacobson; Wendy S Post; Cynthia L Sears
Journal:  J Acquir Immune Defic Syndr       Date:  2016-05-01       Impact factor: 3.731

10.  Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.

Authors:  Zeneng Wang; Elizabeth Klipfell; Brian J Bennett; Robert Koeth; Bruce S Levison; Brandon Dugar; Ariel E Feldstein; Earl B Britt; Xiaoming Fu; Yoon-Mi Chung; Yuping Wu; Phil Schauer; Jonathan D Smith; Hooman Allayee; W H Wilson Tang; Joseph A DiDonato; Aldons J Lusis; Stanley L Hazen
Journal:  Nature       Date:  2011-04-07       Impact factor: 49.962
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  13 in total

1.  Metabolic Profiling of Blood and Urine for Exploring the Functional Role of the Microbiota in Human Health.

Authors:  Ana F Diallo; Mark B Lockwood; Katherine A Maki; Alexis T Franks; Abhrarup Roy; Rosario Jaime-Lara; Paule V Joseph; Wendy A Henderson; Seon Yoon Chung; Jacqueline McGrath; Stefan J Green; Anne M Fink
Journal:  Biol Res Nurs       Date:  2020-07-29       Impact factor: 2.522

Review 2.  Gut microbial metabolites associated with HIV infection.

Authors:  Zheng Wang; Qibin Qi
Journal:  Future Virol       Date:  2019-05-15       Impact factor: 1.831

3.  Association of Lipidomic Profiles With Progression of Carotid Artery Atherosclerosis in HIV Infection.

Authors:  Jin Choul Chai; Amy A Deik; Simin Hua; Tao Wang; David B Hanna; Xiaonan Xue; Sabina A Haberlen; Sanjiv J Shah; Yousin Suh; Jason M Lazar; Deborah Gustafson; Howard N Hodis; Alan L Landay; Kathryn Anastos; Wendy S Post; Robert C Kaplan; Clary B Clish; Qibin Qi
Journal:  JAMA Cardiol       Date:  2019-12-01       Impact factor: 30.154

4.  Carnitine Is Associated With Atherosclerotic Risk and Myocardial Infarction in HIV -Infected Adults.

Authors:  Arjun Sinha; Yifei Ma; Rebecca Scherzer; Smruti Rahalkar; Brendan D Neilan; Heidi Crane; Daniel Drozd; Jeffrey Martin; Steven G Deeks; Peter Hunt; Priscilla Y Hsue
Journal:  J Am Heart Assoc       Date:  2019-05-07       Impact factor: 5.501

Review 5.  Inflammatory and immunometabolic consequences of gut dysfunction in HIV: Parallels with IBD and implications for reservoir persistence and non-AIDS comorbidities.

Authors:  Jehad Alzahrani; Tabinda Hussain; David Simar; Riya Palchaudhuri; Mohamed Abdel-Mohsen; Suzanne M Crowe; George W Mbogo; Clovis S Palmer
Journal:  EBioMedicine       Date:  2019-07-18       Impact factor: 8.143

Review 6.  HIV, Cancer, and the Microbiota: Common Pathways Influencing Different Diseases.

Authors:  Sabina Herrera; Javier Martínez-Sanz; Sergio Serrano-Villar
Journal:  Front Immunol       Date:  2019-06-27       Impact factor: 7.561

Review 7.  Gut Microbiota-Dependent Marker TMAO in Promoting Cardiovascular Disease: Inflammation Mechanism, Clinical Prognostic, and Potential as a Therapeutic Target.

Authors:  Shengjie Yang; Xinye Li; Fan Yang; Ran Zhao; Xiandu Pan; Jiaqi Liang; Li Tian; Xiaoya Li; Longtao Liu; Yanwei Xing; Min Wu
Journal:  Front Pharmacol       Date:  2019-11-19       Impact factor: 5.810

Review 8.  Dysfunctional Immunometabolism in HIV Infection: Contributing Factors and Implications for Age-Related Comorbid Diseases.

Authors:  Tiffany R Butterfield; Alan L Landay; Joshua J Anzinger
Journal:  Curr HIV/AIDS Rep       Date:  2020-04       Impact factor: 5.071

9.  Brief Report: Subclinical Carotid Artery Atherosclerosis Is Associated With Increased Expression of Peripheral Blood IL-32 Isoforms Among Women Living With HIV.

Authors:  Mohamed El-Far; David B Hanna; Madeleine Durand; Etienne Larouche-Anctil; Mohamed Sylla; Carl Chartrand-Lefebvre; Guy Cloutier; Jean Philippe Goulet; Seble Kassaye; Roksana Karim; Jorge R Kizer; Audrey L French; Stephen J Gange; Jason M Lazar; Howard N Hodis; Jean-Pierre Routy; Petronela Ancuta; Nicolas Chomont; Alan L Landay; Robert C Kaplan; Cécile L Tremblay
Journal:  J Acquir Immune Defic Syndr       Date:  2021-10-01       Impact factor: 3.771

10.  Plasma metabolomic study in perinatally HIV-infected children using 1H NMR spectroscopy reveals perturbed metabolites that sustain during therapy.

Authors:  Urvinder Kaur S; Bolaji Fatai Oyeyemi; Anita Shet; Bindu Parachalil Gopalan; Himanshu D; Neel Sarovar Bhavesh; Ravi Tandon
Journal:  PLoS One       Date:  2020-08-31       Impact factor: 3.240
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