Mohammed S El Shimy1, Nehal M El-Raggal1, Rania A El-Farrash1, Hebatallah A Shaaban2, Hanan E Mohamed3, Noha M Barakat1, Ahmed S Farag4, Abeer K El Zohiery5, Menat Allah A Shaaban6, Dina H Salama7. 1. Departments of Pediatrics, Ain Shams University, Cairo, Egypt. 2. Departments of Pediatrics, Ain Shams University, Cairo, Egypt. Heba_Ali@med.asu.edu.eg. 3. Radiodiagnosis, Ain Shams University, Cairo, Egypt. 4. Obstetric and Gynecology, Ain Shams University, Cairo, Egypt. 5. Physical Medicine and Rehabilitation, Ain Shams University, Cairo, Egypt. 6. Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. 7. Radiodiagnosis Department, National Center for Radiation Research and Technology of the Atomic Energy Authority, Cairo, Egypt.
Abstract
BACKGROUND AND OBJECTIVES: Sepsis leads to systemic inflammatory response with cerebral blood flow (CBF) alteration and blood-brain barrier disruption that contribute to sepsis-associated encephalopathy (SAE). We aimed to evaluate cord blood neuron-specific enolase (cNSE) and CBF in early-onset neonatal sepsis (EONS) as predictors of SAE and to define short-term neurodevelopmental outcomes among survivors. METHODS: cNSE was measured in 200 neonates with antenatal risk factors for EONS, stratified into two groups: sepsis (n = 96) and no-sepsis (n = 104). Trans-cranial Doppler of peak systolic velocities (PSV), end diastolic velocities (EDV) and resistive indices (RI) of anterior (ACA) and middle (MCA) cerebral arteries recorded on day 1 postnatal. Griffiths mental developmental scale (GMDS) was assessed at 6 months. RESULTS: Increased cNSE, PSV, EDV, and decreased RI of both ACA and MCA were found in sepsis group compared to no-sepsis group (p < 0.001 for all). Patients with SAE (n = 34) had higher NSE, PSV, and EDV as well as lower RI of ACA and MCA compared to those without (p < 0.01 for all). SAE neonates had lower GMDS than those without. ACA RI of ≤0.61 was the best predictor of SAE. CONCLUSION: High CBF and cNSE could be useful markers for prediction of SAE. SAE impairs neurodevelopmental scales at 6 months.
BACKGROUND AND OBJECTIVES:Sepsis leads to systemic inflammatory response with cerebral blood flow (CBF) alteration and blood-brain barrier disruption that contribute to sepsis-associated encephalopathy (SAE). We aimed to evaluate cord blood neuron-specific enolase (cNSE) and CBF in early-onset neonatal sepsis (EONS) as predictors of SAE and to define short-term neurodevelopmental outcomes among survivors. METHODS: cNSE was measured in 200 neonates with antenatal risk factors for EONS, stratified into two groups: sepsis (n = 96) and no-sepsis (n = 104). Trans-cranial Doppler of peak systolic velocities (PSV), end diastolic velocities (EDV) and resistive indices (RI) of anterior (ACA) and middle (MCA) cerebral arteries recorded on day 1 postnatal. Griffiths mental developmental scale (GMDS) was assessed at 6 months. RESULTS: Increased cNSE, PSV, EDV, and decreased RI of both ACA and MCA were found in sepsis group compared to no-sepsis group (p < 0.001 for all). Patients with SAE (n = 34) had higher NSE, PSV, and EDV as well as lower RI of ACA and MCA compared to those without (p < 0.01 for all). SAE neonates had lower GMDS than those without. ACA RI of ≤0.61 was the best predictor of SAE. CONCLUSION: High CBF and cNSE could be useful markers for prediction of SAE. SAE impairs neurodevelopmental scales at 6 months.
Authors: Bruno Espírito Santo de Araújo; Rosiane da Silva Fontana; Maria Clara de Magalhães-Barbosa; Fernanda Lima-Setta; Vitor Barreto Paravidino; Paula Marins Riveiro; Lucas Berbert Pulcheri; Margarida Dos Santos Salú; Mariana Barros Genuíno-Oliveira; Jaqueline Rodrigues Robaina; Antonio José Ledo Alves da Cunha; Fernanda Ferreira Cruz; Patricia Rieken Macedo Rocco; Fernando Augusto Bozza; Hugo Caire de Castro-Faria-Neto; Arnaldo Prata-Barbosa Journal: Sci Rep Date: 2022-06-23 Impact factor: 4.996
Authors: Ming Ying Gan; Wen Li Lee; Bei Jun Yap; Shu Ting Tammie Seethor; Rachel G Greenberg; Jen Heng Pek; Bobby Tan; Christoph Paul Vincent Hornik; Jan Hau Lee; Shu-Ling Chong Journal: Front Pediatr Date: 2022-06-03 Impact factor: 3.569