Literature DB >> 2990550

Nucleotide sequence of the gene for the gamma chain of human fibrinogen.

M W Rixon, D W Chung, E W Davie.   

Abstract

A human genomic DNA library was screened for the gene coding for the gamma chain of fibrinogen by using a human cDNA for the gamma chain as a hybridization probe. The gene was identified in three overlapping recombinant lambda bacteriophage, and its sequence, including the immediate 5' and 3' flanking regions, was determined. The DNA sequence analysis revealed the presence of 10 exons coding for 411 amino acids present in the mature protein and a signal sequence of 26 amino acids. Two 30 base pair (bp) direct repeats of 93% identity were found 468 bp upstream from the transcription initiation site. The DNA sequence of the gene for the gamma chain of human fibrinogen showed considerable sequence homology with a partial sequence reported for the gene for the gamma chain of rat fibrinogen.

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Year:  1985        PMID： 2990550     DOI： 10.1021/bi00329a041

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  16 in total

1.  Further studies on the topography of the N-terminal region of human platelet glycoprotein IIIa. Localization of monoclonal antibody epitopes and the putative fibrinogen-binding sites.

Authors:  J J Calvete; J Arias; M V Alvarez; M M Lopez; A Henschen; J González-Rodríguez
Journal:  Biochem J       Date:  1991-03-01       Impact factor: 3.857

2.  Carboxyl-terminal amino acid sequences of two variant forms of the gamma chain of human plasma fibrinogen.

Authors:  C W Francis; E Müller; A Henschen; P J Simpson; V J Marder
Journal:  Proc Natl Acad Sci U S A       Date:  1988-05       Impact factor: 11.205

3.  Characterization of the 5'-flanking region for the human fibrinogen beta gene.

Authors:  P Huber; J Dalmon; G Courtois; M Laurent; Z Assouline; G Marguerie
Journal:  Nucleic Acids Res       Date:  1987-02-25       Impact factor: 16.971

4.  The 5' splice site: phylogenetic evolution and variable geometry of association with U1RNA.

Authors:  M Jacob; H Gallinaro
Journal:  Nucleic Acids Res       Date:  1989-03-25       Impact factor: 16.971

5.  Nucleotide sequence of the gamma chain gene of rat fibrinogen: conserved intronic sequences.

Authors:  J G Morgan; N J Holbrook; G R Crabtree
Journal:  Nucleic Acids Res       Date:  1987-03-25       Impact factor: 16.971

Review 6.  An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.

Authors:  M Kozak
Journal:  Nucleic Acids Res       Date:  1987-10-26       Impact factor: 16.971

7.  Molecular basis for fibrinogen Dusart (A alpha 554 Arg-->Cys) and its association with abnormal fibrin polymerization and thrombophilia.

Authors:  J Koopman; F Haverkate; J Grimbergen; S T Lord; M W Mosesson; J P DiOrio; K S Siebenlist; C Legrand; J Soria; C Soria
Journal:  J Clin Invest       Date:  1993-04       Impact factor: 14.808

8.  An examination of the generation-time effect on molecular evolution.

Authors:  T Ohta
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-15       Impact factor: 11.205

9.  Molecular basis of fibrinogen Naples associated with defective thrombin binding and thrombophilia. Homozygous substitution of B beta 68 Ala----Thr.

Authors:  J Koopman; F Haverkate; S T Lord; J Grimbergen; P M Mannucci
Journal:  J Clin Invest       Date:  1992-07       Impact factor: 14.808

10.  Bipartite mRNA for chicken alpha-fibrinogen potentially encodes an amino acid sequence homologous to beta- and gamma-fibrinogens.

Authors:  L Weissbach; G Grieninger
Journal:  Proc Natl Acad Sci U S A       Date:  1990-07       Impact factor: 11.205
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