Literature DB >> 29897302

ORAI Channels as Potential Therapeutic Targets in Pulmonary Hypertension.

Baptiste Rode1,2, Marc A Bailey2, Roger Marthan1,3,4, David J Beech2, Christelle Guibert1,3.   

Abstract

Pulmonary hypertension is a complex and fatal disease that lacks treatments. Its pathophysiology involves pulmonary artery hyperreactivity, endothelial dysfunction, wall remodelling, inflammation, and thrombosis, which could all depend on ORAI Ca2+ channels. We review the knowledge about ORAI channels in pulmonary artery and discuss the interest to target them in the treatment of pulmonary hypertension.

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Year:  2018        PMID： 29897302     DOI： 10.1152/physiol.00016.2018

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  10 in total

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Review 5.  ORAI1 Ca2+ Channel as a Therapeutic Target in Pathological Vascular Remodelling.

Authors:  Heba Shawer; Katherine Norman; Chew W Cheng; Richard Foster; David J Beech; Marc A Bailey
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7.  Parathyroid Hormone Promotes Human Umbilical Vein Endothelial Cell Migration and Proliferation Through Orai1-Mediated Calcium Signaling.

Authors:  Shuhao Wang; Lijie Xu; Yv Wu; Hailong Shen; Zhangying Lin; Yang Fang; Lesha Zhang; Bing Shen; Yehai Liu; Kaile Wu
Journal:  Front Cardiovasc Med       Date:  2022-03-16

8.  Identifying the Effect of Nuanxin Capsules on Myocardial Injury Induced by Chronic Hypoxia via Network Pharmacology Analysis and Experimental Validation.

Authors:  Zhexing Mai; Ye Fan; Jin Ma; Tiantian Lou; Shiyu Ma; Xu Zou
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9.  Preventive treatment with ginsenoside Rb1 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats and involves store-operated calcium entry inhibition.

Authors:  Rui-Xing Wang; Rui-Lan He; Hai-Xia Jiao; Run-Tian Zhang; Jing-Yi Guo; Xiao-Ru Liu; Long-Xin Gui; Mo-Jun Lin; Zhi-Juan Wu
Journal:  Pharm Biol       Date:  2020-12       Impact factor: 3.503

10.  Transcriptomic profile of cationic channels in human pulmonary arterial hypertension.

Authors:  Francisco Perez-Vizcaino; Angel Cogolludo; Gema Mondejar-Parreño
Journal:  Sci Rep       Date:  2021-08-04       Impact factor: 4.379
  10 in total

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