Literature DB >> 29891605

In Vitro Activity of Ceftazidime-Avibactam against Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae Isolates.

Fangyou Yu1,2, Jingnan Lv2, Siqiang Niu3, Hong Du4, Yi-Wei Tang5,6, Robert A Bonomo7,8,9,10,11, Barry N Kreiswirth12, Liang Chen13.   

Abstract

Carbapenem-resistant and hypervirulent Klebsiella pneumoniae (CR-hvKp) strains have emerged while antimicrobial treatment options remain limited. Herein, we tested the in vitro activity of ceftazidime-avibactam and other comparator antibiotics against 65 CR-hvKp isolates. Ceftazidime-avibactam, colistin, and tigecycline are highly active in vitro against CR-hvKp isolates (MIC90, ≤1 μg/ml), including K. pneumoniae carbapenemase 2 (KPC-2)-producing ST11 CR-hvKp. On the basis of previous clinical experience and the in vitro data presented herein, we posit that ceftazidime-avibactam is a therapeutic option against CR-hvKp infections.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  carbapenem resistance; ceftazidime-avibactam; hypervirulent Klebsiella pneumoniae; susceptibility

Mesh：

Substances：

Year:  2018        PMID： 29891605      PMCID： PMC6105775          DOI： 10.1128/AAC.01031-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

Review 1.  Hypervirulence and hypermucoviscosity: Two different but complementary Klebsiella spp. phenotypes?

Authors:  Juan Carlos Catalán-Nájera; Ulises Garza-Ramos; Humberto Barrios-Camacho
Journal:  Virulence       Date:  2017-04-12       Impact factor: 5.882

2.  Aerobactin, but not yersiniabactin, salmochelin, or enterobactin, enables the growth/survival of hypervirulent (hypermucoviscous) Klebsiella pneumoniae ex vivo and in vivo.

Authors:  Thomas A Russo; Ruth Olson; Ulrike MacDonald; Janet Beanan; Bruce A Davidson
Journal:  Infect Immun       Date:  2015-06-08       Impact factor: 3.441

3.  Ceftazidime-Avibactam Is Superior to Other Treatment Regimens against Carbapenem-Resistant Klebsiella pneumoniae Bacteremia.

Authors:  Ryan K Shields; M Hong Nguyen; Liang Chen; Ellen G Press; Brian A Potoski; Rachel V Marini; Yohei Doi; Barry N Kreiswirth; Cornelius J Clancy
Journal:  Antimicrob Agents Chemother       Date:  2017-07-25       Impact factor: 5.191

4.  A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study.

Authors:  Danxia Gu; Ning Dong; Zhiwei Zheng; Di Lin; Man Huang; Lihua Wang; Edward Wai-Chi Chan; Lingbin Shu; Jiang Yu; Rong Zhang; Sheng Chen
Journal:  Lancet Infect Dis       Date:  2017-08-29       Impact factor: 25.071

Review 5.  Ceftazidime/Avibactam and Ceftolozane/Tazobactam: Second-generation β-Lactam/β-Lactamase Inhibitor Combinations.

Authors:  David van Duin; Robert A Bonomo
Journal:  Clin Infect Dis       Date:  2016-04-20       Impact factor: 9.079

6.  Mutations of the ompK36 porin gene and promoter impact responses of sequence type 258, KPC-2-producing Klebsiella pneumoniae strains to doripenem and doripenem-colistin.

Authors:  Cornelius J Clancy; Liang Chen; Jae H Hong; Shaoji Cheng; Binghua Hao; Ryan K Shields; Annie N Farrell; Yohei Doi; Yanan Zhao; David S Perlin; Barry N Kreiswirth; M Hong Nguyen
Journal:  Antimicrob Agents Chemother       Date:  2013-08-12       Impact factor: 5.191

7.  Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study.

Authors:  Yi-Yun Liu; Yang Wang; Timothy R Walsh; Ling-Xian Yi; Rong Zhang; James Spencer; Yohei Doi; Guobao Tian; Baolei Dong; Xianhui Huang; Lin-Feng Yu; Danxia Gu; Hongwei Ren; Xiaojie Chen; Luchao Lv; Dandan He; Hongwei Zhou; Zisen Liang; Jian-Hua Liu; Jianzhong Shen
Journal:  Lancet Infect Dis       Date:  2015-11-19       Impact factor: 25.071

8.  wzi Gene sequencing, a rapid method for determination of capsular type for Klebsiella strains.

Authors:  Sylvain Brisse; Virginie Passet; Anita Björk Haugaard; Anamaria Babosan; Najiby Kassis-Chikhani; Carsten Struve; Dominique Decré
Journal:  J Clin Microbiol       Date:  2013-10-02       Impact factor: 5.948

Review 9.  Antimicrobial Resistance of Hypervirulent Klebsiella pneumoniae: Epidemiology, Hypervirulence-Associated Determinants, and Resistance Mechanisms.

Authors:  Chang-Ro Lee; Jung Hun Lee; Kwang Seung Park; Jeong Ho Jeon; Young Bae Kim; Chang-Jun Cha; Byeong Chul Jeong; Sang Hee Lee
Journal:  Front Cell Infect Microbiol       Date:  2017-11-21       Impact factor: 5.293

10.  Genome analysis of clinical multilocus sequence Type 11 Klebsiella pneumoniae from China.

Authors:  Ning Dong; Rong Zhang; Lizhang Liu; Ruichao Li; Dachuan Lin; Edward Wai-Chi Chan; Sheng Chen
Journal:  Microb Genom       Date:  2018-02-08
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  8 in total

Review 1.  Hypervirulent Klebsiella pneumoniae.

Authors:  Thomas A Russo; Candace M Marr
Journal:  Clin Microbiol Rev       Date:  2019-05-15       Impact factor: 26.132

2.  Emergence of Hypervirulent Ceftazidime/Avibactam-Resistant Klebsiella pneumoniae Isolates in a Chinese Tertiary Hospital.

Authors:  Dan Li; Wenjian Liao; Hai-Hua Huang; Fang-Ling Du; Dan-Dan Wei; Yan-Fang Mei; Dan Long; La-Gen Wan; Yang Liu; Wei Zhang
Journal:  Infect Drug Resist       Date:  2020-08-03       Impact factor: 4.003

Review 3.  Carbapenemases in Enterobacteriaceae: Detection and Antimicrobial Therapy.

Authors:  Xiaoyan Cui; Haifang Zhang; Hong Du
Journal:  Front Microbiol       Date:  2019-08-20       Impact factor: 5.640

4.  Pyogenic Liver Abscess and Endogenous Endophthalmitis Due to K64-ST1764 Hypervirulent Klebsiella pneumoniae: A Case Report.

Authors:  Bo Zhao; Renjing Hu; Lei Gong; Xiaoyun Wang; Yingwei Zhu; Gaojue Wu
Journal:  Infect Drug Resist       Date:  2021-01-12       Impact factor: 4.003

5.  Emergence of Colistin Resistance in Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae Under the Pressure of Tigecycline.

Authors:  Yawei Zhang; Xiaojuan Wang; Shifu Wang; Shijun Sun; Henan Li; Hongbin Chen; Qi Wang; Hui Wang
Journal:  Front Microbiol       Date:  2021-12-01       Impact factor: 5.640

6.  Emergence of Hypervirulent ST11-K64 Klebsiella pneumoniae Poses a Serious Clinical Threat in Older Patients.

Authors:  Tian Wei; Chengyun Zou; Jie Qin; Jianmin Tao; Li Yan; Jiangjun Wang; Hong Du; Fang Shen; Yanqin Zhao; Haiying Wang
Journal:  Front Public Health       Date:  2022-03-04

7.  Ceftazidime-avibactam based combinations against carbapenemase producing Klebsiella pneumoniae harboring hypervirulence plasmids.

Authors:  Zackery P Bulman; Xing Tan; Ting-Yu Chu; Yanqin Huang; Amisha P Rana; Nidhi Singh; Stephanie A Flowers; Yasuhiro Kyono; Barry N Kreiswirth; Liang Chen
Journal:  Comput Struct Biotechnol J       Date:  2022-07-15       Impact factor: 6.155

8.  In vitro Activity of Apramycin Against Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae Isolates.

Authors:  Mingju Hao; Xiaohong Shi; Jingnan Lv; Siqiang Niu; Shiqing Cheng; Hong Du; Fangyou Yu; Yi-Wei Tang; Barry N Kreiswirth; Haifang Zhang; Liang Chen
Journal:  Front Microbiol       Date:  2020-03-13       Impact factor: 5.640
  8 in total

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