BACKGROUND: There is accumulating evidence suggesting that diet may play a role in preventing or delaying cognitive decline and dementia, but the underlying biological mechanisms are not well understood. OBJECTIVES: To examine the cross-sectional associations of the Mediterranean diet (MeDi) and its components with 11C-PiB-PET scan measures of amyloid-β (Aβ) deposition. METHODS: The study consisted of 278 Mayo Clinic Study of Aging participants 70+ years old, who were cognitively unimpaired (CU) at the time of completion of the Food Frequency Questionnaire (FFQ) and when they underwent PET imaging. Adherence to the MeDi was assessed by computing the MeDi score for each participant. All scans were performed after the FFQ completion; median [IQR] time between FFQ and Aβ PET was 3.5 (1.4) years. Z-scores were created for component, macro- and micronutrients measured. Linear and logistic regression models were adjusted for age, sex, education, apolipoprotein E (APOE) ɛ4 allele carrier status, time interval between the FFQ completion and PET scan, and total energy intake. RESULTS: Participants' median age at FFQ was 77.7 years (55.8% men; 26.6% with an APOE ɛ4 allele). Higher MeDi score (linear regression slope (beta):-0.035, p = 0.012; per standard deviation increase), vegetable intake (beta:-0.043, p = 0.002), intake of vitamin A (beta:-0.041, p = 0.003) or β-carotene (beta: -0.039, p = 0.005) from food sources and moderate alcohol consumption (beta: -0.074, p = 0.03) were associated with lower 11C-PiB standardized uptake value ratio. CONCLUSION: Findings are consistent with previous studies suggesting that higher adherence to a MeDi pattern and higher vegetable consumption are associated with better neuroimaging biomarker profile. Prospective studies are needed to validate current findings.
BACKGROUND: There is accumulating evidence suggesting that diet may play a role in preventing or delaying cognitive decline and dementia, but the underlying biological mechanisms are not well understood. OBJECTIVES: To examine the cross-sectional associations of the Mediterranean diet (MeDi) and its components with 11C-PiB-PET scan measures of amyloid-β (Aβ) deposition. METHODS: The study consisted of 278 Mayo Clinic Study of Aging participants 70+ years old, who were cognitively unimpaired (CU) at the time of completion of the Food Frequency Questionnaire (FFQ) and when they underwent PET imaging. Adherence to the MeDi was assessed by computing the MeDi score for each participant. All scans were performed after the FFQ completion; median [IQR] time between FFQ and Aβ PET was 3.5 (1.4) years. Z-scores were created for component, macro- and micronutrients measured. Linear and logistic regression models were adjusted for age, sex, education, apolipoprotein E (APOE) ɛ4 allele carrier status, time interval between the FFQ completion and PET scan, and total energy intake. RESULTS:Participants' median age at FFQ was 77.7 years (55.8% men; 26.6% with an APOE ɛ4 allele). Higher MeDi score (linear regression slope (beta):-0.035, p = 0.012; per standard deviation increase), vegetable intake (beta:-0.043, p = 0.002), intake of vitamin A (beta:-0.041, p = 0.003) or β-carotene (beta: -0.039, p = 0.005) from food sources and moderate alcohol consumption (beta: -0.074, p = 0.03) were associated with lower 11C-PiB standardized uptake value ratio. CONCLUSION: Findings are consistent with previous studies suggesting that higher adherence to a MeDi pattern and higher vegetable consumption are associated with better neuroimaging biomarker profile. Prospective studies are needed to validate current findings.
Authors: Jennifer L St Sauver; Brandon R Grossardt; Barbara P Yawn; L Joseph Melton; Joshua J Pankratz; Scott M Brue; Walter A Rocca Journal: Int J Epidemiol Date: 2012-11-18 Impact factor: 7.196
Authors: Martha Clare Morris; Yamin Wang; Lisa L Barnes; David A Bennett; Bess Dawson-Hughes; Sarah L Booth Journal: Neurology Date: 2017-12-20 Impact factor: 9.910
Authors: V Berti; J Murray; M Davies; N Spector; W H Tsui; Y Li; S Williams; E Pirraglia; S Vallabhajosula; P McHugh; A Pupi; M J de Leon; L Mosconi Journal: J Nutr Health Aging Date: 2015-04 Impact factor: 4.075
Authors: David A Merrill; Prabha Siddarth; Cyrus A Raji; Natacha D Emerson; Florangel Rueda; Linda M Ercoli; Karen J Miller; Helen Lavretsky; Laurel M Harris; Alison C Burggren; Susan Y Bookheimer; Jorge R Barrio; Gary W Small Journal: Am J Geriatr Psychiatry Date: 2016-05-13 Impact factor: 4.105
Authors: Balwinder Singh; Ajay K Parsaik; Michelle M Mielke; Patricia J Erwin; David S Knopman; Ronald C Petersen; Rosebud O Roberts Journal: J Alzheimers Dis Date: 2014 Impact factor: 4.472
Authors: Taylor J Krivanek; Seth A Gale; Brittany M McFeeley; Casey M Nicastri; Kirk R Daffner Journal: J Alzheimers Dis Date: 2021 Impact factor: 4.472
Authors: Tommaso Ballarini; Debora Melo van Lent; Julia Brunner; Alina Schröder; Steffen Wolfsgruber; Slawek Altenstein; Frederic Brosseron; Katharina Buerger; Peter Dechent; Laura Dobisch; Emrah Duzel; Birgit Ertl-Wagner; Klaus Fliessbach; Silka Dawn Freiesleben; Ingo Frommann; Wenzel Glanz; Dietmar Hauser; John Dylan Haynes; Michael T Heneka; Daniel Janowitz; Ingo Kilimann; Christoph Laske; Franziska Maier; Coraline Danielle Metzger; Matthias Munk; Robert Perneczky; Oliver Peters; Josef Priller; Alfredo Ramirez; Boris Rauchmann; Nina Roy; Klaus Scheffler; Anja Schneider; Annika Spottke; Eike Jakob Spruth; Stefan J Teipel; Ruth Vukovich; Jens Wiltfang; Frank Jessen; Michael Wagner Journal: Neurology Date: 2021-05-05 Impact factor: 9.910
Authors: Jessica Samuelsson; Silke Kern; Henrik Zetterberg; Kaj Blennow; Elisabet Rothenberg; Ola Wallengren; Ingmar Skoog; Anna Zettergren Journal: Alzheimers Dement (N Y) Date: 2021-05-18
Authors: Oliver M Shannon; Vivian Lee; Rafe Bundy; Rachel Gillings; Amy Jennings; Blossom Stephan; Michael Hornberger; George Balanos; Stella Maria Paddick; Sarah Hanson; Wendy Hardeman; Rebecca Holmes; Nikki Garner; Sarah Aldred; Mario Siervo; John C Mathers; Anne Marie Minihane Journal: BMJ Open Date: 2021-02-05 Impact factor: 2.692