A J Colon1, M J P van Osch2, M Buijs2, J V D Grond2, A Hillebrand3, O Schijns4, G J Wagner5, P Ossenblok6, P Hofman5, M A V Buchem2, P Boon7. 1. ACE Kempenhaeghe/MUMC+, Dep. of Epileptology, Loc Heeze, The Netherlands; ACE Kempenhaeghe/MUMC+, Dep. of Neurosurgery, Loc Maastricht, The Netherlands. Electronic address: colona@kempenhaeghe.nl. 2. LUMC, Dep. of Radiology, Leiden, The Netherlands. 3. VUmc, Dep. of Clinical Neurophysiologie, Amsterdam, The Netherlands. 4. ACE Kempenhaeghe/MUMC+, Dep. of Neurosurgery, Loc Maastricht, The Netherlands. 5. ACE Kempenhaeghe/MUMC+, Dep. of Epileptology, Loc Heeze, The Netherlands; ACE Kempenhaeghe/MUMC+, Dep. of Neurosurgery, Loc Maastricht, The Netherlands. 6. TU/e, Eindhoven, The Netherlands. 7. ACE Kempenhaeghe/MUMC+, Dep. of Epileptology, Loc Heeze, The Netherlands; UGent, Dep. of Neurology, Gent, Belgium.
Abstract
PURPOSE: To study possible detection of structural abnormalities on 7T MRI that were not detected on 3T MRI and estimate the added value of MEG-guidance. For abnormalities found, analysis of convergence between clinical, MEG and 7T MRI localization of suspected epileptogenic foci. METHODS: In adult patients with well-documented localization-related epilepsy in whom a previous 3T MRI did not demonstrate an epileptogenic lesion but MEG indicated a plausible epileptogenic focus, 7T MRI was performed. Based on semiologic data, visual analysis of the 7T images was performed as well as based on prior MEG results. Correlation with other data from the patient charts, for as far as these were available, was analysed. To establish the level of concordance between the three observers the generalized or Fleiss kappa was calculated. RESULTS: In 3/19 patients abnormalities that, based on semiology, could plausibly represent an epileptogenic lesion were detected using 7T MRI. In an additional 3/19 an abnormality was detected after MEG-guidance. However, in these later cases there was no concordance among the three observers with regard to the presence of a structural abnormality. In one of these three cases intracranial recording was performed, proving the possible abnormality on 7T MRI to be the epileptogenic focus. CONCLUSIONS: In 32% of patients 7T MRI showed abnormalities that could indicate an epileptogenic lesion whereas previous 3T MRI did not, especially when visual inspection was guided by the presence of focal interictal MEG abnormalities.
PURPOSE: To study possible detection of structural abnormalities on 7T MRI that were not detected on 3T MRI and estimate the added value of MEG-guidance. For abnormalities found, analysis of convergence between clinical, MEG and 7T MRI localization of suspected epileptogenic foci. METHODS: In adult patients with well-documented localization-related epilepsy in whom a previous 3T MRI did not demonstrate an epileptogenic lesion but MEG indicated a plausible epileptogenic focus, 7T MRI was performed. Based on semiologic data, visual analysis of the 7T images was performed as well as based on prior MEG results. Correlation with other data from the patient charts, for as far as these were available, was analysed. To establish the level of concordance between the three observers the generalized or Fleiss kappa was calculated. RESULTS: In 3/19 patients abnormalities that, based on semiology, could plausibly represent an epileptogenic lesion were detected using 7T MRI. In an additional 3/19 an abnormality was detected after MEG-guidance. However, in these later cases there was no concordance among the three observers with regard to the presence of a structural abnormality. In one of these three cases intracranial recording was performed, proving the possible abnormality on 7T MRI to be the epileptogenic focus. CONCLUSIONS: In 32% of patients 7T MRI showed abnormalities that could indicate an epileptogenic lesion whereas previous 3T MRI did not, especially when visual inspection was guided by the presence of focal interictal MEG abnormalities.
Authors: R H G J van Lanen; C J Wiggins; A J Colon; W H Backes; J F A Jansen; D Uher; G S Drenthen; A Roebroeck; D Ivanov; B A Poser; M C Hoeberigs; S M J van Kuijk; G Hoogland; K Rijkers; G L Wagner; J Beckervordersandforth; D Delev; H Clusmann; S Wolking; S Klinkenberg; R P W Rouhl; P A M Hofman; O E M G Schijns Journal: Neuroradiology Date: 2022-01-05 Impact factor: 2.804
Authors: Giske Opheim; Anja van der Kolk; Karin Markenroth Bloch; Albert J Colon; Kathryn A Davis; Thomas R Henry; Jacobus F A Jansen; Stephen E Jones; Jullie W Pan; Karl Rössler; Joel M Stein; Maria C Strandberg; Siegfried Trattnig; Pierre-Francois Van de Moortele; Maria Isabel Vargas; Irene Wang; Fabrice Bartolomei; Neda Bernasconi; Andrea Bernasconi; Boris Bernhardt; Isabella Björkman-Burtscher; Mirco Cosottini; Sandhitsu R Das; Lucie Hertz-Pannier; Sara Inati; Michael T Jurkiewicz; Ali R Khan; Shuli Liang; Ruoyun Emily Ma; Srinivasan Mukundan; Heath Pardoe; Lars H Pinborg; Jonathan R Polimeni; Jean-Philippe Ranjeva; Esther Steijvers; Steven Stufflebeam; Tim J Veersema; Alexandre Vignaud; Natalie Voets; Serge Vulliemoz; Christopher J Wiggins; Rong Xue; Renzo Guerrini; Maxime Guye Journal: Neurology Date: 2020-12-22 Impact factor: 9.910