Literature DB >> 3395104

Animal model for evaluating the convulsive liability of beta-lactam antibiotics.

P D Williams1, D B Bennett, C R Comereski.   

Abstract

The beta-lactam antibiotics imipenem-cilastatin, BMY-26225, and cefazolin significantly lowered the convulsive threshold of pentylenetetrazole in mice. In addition, imipenem-cilastatin and cefazolin were found to inhibit 3H-labeled gamma-aminobutyric acid binding to synaptic membranes from rat brains. Our results suggest that the pentylenetetrazole convulsive model may be useful in evaluating the proconvulsive liabilities of new carbapenems and other beta-lactam antibiotics and that the mechanism of imipenem-cilastatin and cefazolin toxicity may involve interaction with gamma-aminobutyric acid receptors.

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Year:  1988        PMID： 3395104      PMCID： PMC172267          DOI： 10.1128/AAC.32.5.758

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Comparative assays of antiepileptic drugs in mice and rats.

Authors:  E A SWINYARD; W C BROWN; L S GOODMAN
Journal:  J Pharmacol Exp Ther       Date:  1952-11       Impact factor: 4.030

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Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
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Journal:  Brain Res       Date:  1972-08-11       Impact factor: 3.252

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Authors:  M E Raichle; H Kutt; S Louis; F McDowell
Journal:  Arch Neurol       Date:  1971-09

Review 5.  Imipenem: first of a new class of beta-lactam antibiotics.

Authors:  M Barza
Journal:  Ann Intern Med       Date:  1985-10       Impact factor: 25.391

6.  A new model of experimental epilepsy: the cefazolin-induced epilepsy.

Authors:  D Rotiroti; G B de Sarro; R Musolino; G Nisticò
Journal:  Prog Clin Biol Res       Date:  1983

7.  Convulsions associated with sodium cefazolin: a case report.

Authors:  R L Yost; J D Lee; J P O'Leary
Journal:  Am Surg       Date:  1977-06       Impact factor: 0.688

Review 8.  Review of imipenem.

Authors:  S Y Park; R H Parker
Journal:  Infect Control       Date:  1986-06

9.  Gamma-aminobutyric acid binding to receptor sites in the rat central nervous system.

Authors:  S R Zukin; A B Young; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1974-12       Impact factor: 11.205

10.  Primaxin in the treatment of acute bacterial pneumonia in adults.

Authors:  R J Gebhart; R J Duma; P M Patterson; J W Bagett; D S Williams
Journal:  J Antimicrob Chemother       Date:  1985-02       Impact factor: 5.790
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  13 in total

1.  Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of imipenem in healthy rats.

Authors:  A Dupuis; W Couet; J Paquereau; S Debarre; A Portron; C Jamois; S Bouquet
Journal:  Antimicrob Agents Chemother       Date:  2001-06       Impact factor: 5.191

Review 2.  Comparative pharmacokinetics of the carbapenems: clinical implications.

Authors:  J W Mouton; D J Touzw; A M Horrevorts; A A Vinks
Journal:  Clin Pharmacokinet       Date:  2000-09       Impact factor: 6.447

3.  Pharmacokinetics of meropenem in subjects with various degrees of renal impairment.

Authors:  B A Christensson; I Nilsson-Ehle; M Hutchison; S J Haworth; B Oqvist; S R Norrby
Journal:  Antimicrob Agents Chemother       Date:  1992-07       Impact factor: 5.191

4.  Convulsive liability of cefepime and meropenem in normal and corneal kindled mice.

Authors:  Akihiro Tanaka; Kenshi Takechi; Shinichi Watanabe; Mamoru Tanaka; Katsuya Suemaru; Hiroaki Araki
Journal:  Antimicrob Agents Chemother       Date:  2014-05-19       Impact factor: 5.191

Review 5.  Neurotoxicity induced by beta-lactam antibiotics: from bench to bedside.

Authors:  K M Chow; A C Hui; C C Szeto
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2005-10       Impact factor: 3.267

6.  Effects of amoxicillin-clavulanate combination on the motility of the small intestine in human beings.

Authors:  F Caron; P Ducrotte; E Lerebours; R Colin; G Humbert; P Denis
Journal:  Antimicrob Agents Chemother       Date:  1991-06       Impact factor: 5.191

7.  Relationship between structure and convulsant properties of some beta-lactam antibiotics following intracerebroventricular microinjection in rats.

Authors:  A De Sarro; D Ammendola; M Zappala; S Grasso; G B De Sarro
Journal:  Antimicrob Agents Chemother       Date:  1995-01       Impact factor: 5.191

8.  Pharmacodynamics of phenobarbital anesthesia and pentylenetetrazol-induced maximal seizures in a rat model of neoplastic spinal cord compression.

Authors:  A Hoffman; J Alfon; T Siegal; T Siegal
Journal:  Pharm Res       Date:  1994-04       Impact factor: 4.200

9.  Low neurotoxicity of LJC 10,627, a novel 1 beta-methyl carbapenem antibiotic: inhibition of gamma-aminobutyric acidA, benzodiazepine, and glycine receptor binding in relation to lack of central nervous system toxicity in rats.

Authors:  M Hikida; Y Masukawa; K Nishiki; N Inomata
Journal:  Antimicrob Agents Chemother       Date:  1993-02       Impact factor: 5.191

10.  High-dose methotrexate does not affect the pharmacodynamics of phenobarbital hypnotic action but decreases the central nervous system (CNS) sensitivity to pentylenetetrazol-induced maximal seizures in rats.

Authors:  A Hoffman; J Alfon
Journal:  Pharm Res       Date:  1992-10       Impact factor: 4.200
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