Literature DB >> 29883601

Toxins that Trash Translation.

Allen R Buskirk1.   

Abstract

Culviner and Laub (2018) use RNA-seq and ribosome profiling to determine how MazF inhibits translation in E. coli. Challenging an earlier model, they argue that MazF cleaves mRNA and blocks ribosome biogenesis but does not generate specialized ribosomes that preferentially translate leaderless transcripts.
Copyright © 2018 Elsevier Inc. All rights reserved.

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Year:  2018        PMID： 29883601      PMCID： PMC6188653          DOI： 10.1016/j.molcel.2018.05.027

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  10 in total

1.  Crystal structure of the MazE/MazF complex: molecular bases of antidote-toxin recognition.

Authors:  Katsuhiko Kamada; Fumio Hanaoka; Stephen K Burley
Journal:  Mol Cell       Date:  2003-04       Impact factor: 17.970

2.  Global Analysis of the E. coli Toxin MazF Reveals Widespread Cleavage of mRNA and the Inhibition of rRNA Maturation and Ribosome Biogenesis.

Authors:  Peter H Culviner; Michael T Laub
Journal:  Mol Cell       Date:  2018-05-31       Impact factor: 17.970

3.  Selective translation of leaderless mRNAs by specialized ribosomes generated by MazF in Escherichia coli.

Authors:  Oliver Vesper; Shahar Amitai; Maria Belitsky; Konstantin Byrgazov; Anna Chao Kaberdina; Hanna Engelberg-Kulka; Isabella Moll
Journal:  Cell       Date:  2011-09-22       Impact factor: 41.582

Review 4.  Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology.

Authors:  Alexander Harms; Ditlev Egeskov Brodersen; Namiko Mitarai; Kenn Gerdes
Journal:  Mol Cell       Date:  2018-02-03       Impact factor: 17.970

Review 5.  Ribosomopathies: There's strength in numbers.

Authors:  Eric W Mills; Rachel Green
Journal:  Science       Date:  2017-11-03       Impact factor: 47.728

Review 6.  Heterogeneity and specialized functions of translation machinery: from genes to organisms.

Authors:  Naomi R Genuth; Maria Barna
Journal:  Nat Rev Genet       Date:  2018-07       Impact factor: 53.242

Review 7.  Toxin-antitoxin systems in bacterial growth arrest and persistence.

Authors:  Rebecca Page; Wolfgang Peti
Journal:  Nat Chem Biol       Date:  2016-04       Impact factor: 15.040

8.  MazF cleaves cellular mRNAs specifically at ACA to block protein synthesis in Escherichia coli.

Authors:  Yonglong Zhang; Junjie Zhang; Klaus P Hoeflich; Mitsuhiko Ikura; Guoliang Qing; Masayori Inouye
Journal:  Mol Cell       Date:  2003-10       Impact factor: 17.970

9.  A ribosome profiling study of mRNA cleavage by the endonuclease RelE.

Authors:  Jae-Yeon Hwang; Allen R Buskirk
Journal:  Nucleic Acids Res       Date:  2016-10-18       Impact factor: 16.971

10.  An RNA-seq method for defining endoribonuclease cleavage specificity identifies dual rRNA substrates for toxin MazF-mt3.

Authors:  Jason M Schifano; Irina O Vvedenskaya; Jared G Knoblauch; Ming Ouyang; Bryce E Nickels; Nancy A Woychik
Journal:  Nat Commun       Date:  2014-04-08       Impact factor: 14.919
  10 in total

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