Literature DB >> 29880920

Overcoming the legal and regulatory barriers to drug repurposing.

Alasdair Breckenridge1, Robin Jacob2.   

Abstract

Drug repurposing has been proposed as a strategy to develop new therapies that has fewer risks, lower costs and shorter timelines than developing completely new drugs. However, the potential of this strategy has not been as widely realized as hoped, in part owing to legal and regulatory barriers. Here, we highlight these barriers and consider how they could be overcome.

Mesh：

Year:  2018        PMID： 29880920     DOI： 10.1038/nrd.2018.92

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  2 in total

Review 1.  Drug repositioning: identifying and developing new uses for existing drugs.

Authors:  Ted T Ashburn; Karl B Thor
Journal:  Nat Rev Drug Discov       Date:  2004-08       Impact factor: 84.694

Review 2.  Follow-on biologics: data exclusivity and the balance between innovation and competition.

Authors:  Henry Grabowski
Journal:  Nat Rev Drug Discov       Date:  2008-05-12       Impact factor: 84.694
  2 in total
  35 in total

Review 1.  Gauging the role and impact of drug interactions and repurposing in neurodegenerative disorders.

Authors:  Dharmendra Kumar Khatri; Amey Kadbhane; Monica Patel; Shweta Nene; Srividya Atmakuri; Saurabh Srivastava; Shashi Bala Singh
Journal:  Curr Res Pharmacol Drug Discov       Date:  2021-04-08

2.  European patent protection for medical uses of known products and drug repurposing.

Authors:  Mateo Aboy; Kathleen Liddell; Matthew Jordan; Cristina Crespo; Johnathon Liddicoat
Journal:  Nat Biotechnol       Date:  2022-04       Impact factor: 54.908

Review 3.  Drug repurposing-an emerging strategy in cancer therapeutics.

Authors:  Khadija Shahab Turabi; Ankita Deshmukh; Sayan Paul; Dayanand Swami; Shafina Siddiqui; Urwashi Kumar; Shreelekha Naikar; Shine Devarajan; Soumya Basu; Manash K Paul; Jyotirmoi Aich
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2022-06-13       Impact factor: 3.195

Review 4.  Therapeutic strategies for tauopathies and drug repurposing as a potential approach.

Authors:  Majedul Islam; Fengyun Shen; Deepika Regmi; Deguo Du
Journal:  Biochem Pharmacol       Date:  2022-02-24       Impact factor: 6.100

Review 5.  Drug repurposing: progress, challenges and recommendations.

Authors:  Sudeep Pushpakom; Francesco Iorio; Patrick A Eyers; K Jane Escott; Shirley Hopper; Andrew Wells; Andrew Doig; Tim Guilliams; Joanna Latimer; Christine McNamee; Alan Norris; Philippe Sanseau; David Cavalla; Munir Pirmohamed
Journal:  Nat Rev Drug Discov       Date:  2018-10-12       Impact factor: 84.694

Review 6.  Aberrant Complement System Activation in Neurological Disorders.

Authors:  Karolina Ziabska; Malgorzata Ziemka-Nalecz; Paulina Pawelec; Joanna Sypecka; Teresa Zalewska
Journal:  Int J Mol Sci       Date:  2021-04-28       Impact factor: 5.923

Review 7.  Drug targets for COVID-19 therapeutics: Ongoing global efforts.

Authors:  Ambrish Saxena
Journal:  J Biosci       Date:  2020       Impact factor: 1.826

Review 8.  Repurposing of Anticancer Stem Cell Drugs in Brain Tumors.

Authors:  Hisham F Bahmad; Darine Daher; Abed A Aljamal; Mohamad K Elajami; Kei Shing Oh; Juan Carlos Alvarez Moreno; Ruben Delgado; Richard Suarez; Ana Zaldivar; Roshanak Azimi; Amilcar Castellano; Robert Sackstein; Robert J Poppiti
Journal:  J Histochem Cytochem       Date:  2021-06-24       Impact factor: 2.479

9.  Editorial: Repurposed Drugs Targeting Cancer Signaling Pathways: Clinical Insights to Improve Oncologic Therapies.

Authors:  Carlos Pérez-Plasencia; Teresita Padilla-Benavides; Eduardo López-Urrutia; Alma D Campos-Parra
Journal:  Front Oncol       Date:  2021-06-23       Impact factor: 6.244

10.  Limited Treatment Options for Diabetic Wounds: Barriers to Clinical Translation Despite Therapeutic Success in Murine Models.

Authors:  May Barakat; Luisa A DiPietro; Lin Chen
Journal:  Adv Wound Care (New Rochelle)       Date:  2020-12-18       Impact factor: 4.947
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