Literature DB >> 2987816

Drosophila topoisomerase II double-strand DNA cleavage: analysis of DNA sequence homology at the cleavage site.

M Sander, T S Hsieh.   

Abstract

In order to study the sequence specificity of double-strand DNA cleavage by Drosophila topoisomerase II, we have mapped and sequenced 16 strong and 47 weak cleavage sites in the recombinant plasmid p pi 25.1. Analysis of the nucleotide and dinucleotide frequencies in the region near the site of phosphodiester bond breakage revealed a nonrandom distribution. The nucleotide frequencies observed would occur by chance with a probability less than 0.05. The consensus sequence we derived is 5'GT.A/TAY decrease ATT.AT..G 3', where a dot means no preferred nucleotide, Y is for pyrimidine, and the arrow shows the point of bond cleavage. On average, strong sites match the consensus better than weak sites.

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Year:  1985        PMID： 2987816      PMCID： PMC341056          DOI： 10.1093/nar/13.4.1057

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  32 in total

1.  Strand breakage by the DNA untwisting enzyme results in covalent attachment of the enzyme to DNA.

Authors:  J J Champoux
Journal:  Proc Natl Acad Sci U S A       Date:  1977-09       Impact factor: 11.205

2.  Site-specific cleavage of DNA by E. coli DNA gyrase.

Authors:  A Morrison; N R Cozzarelli
Journal:  Cell       Date:  1979-05       Impact factor: 41.582

3.  Phosphorylation of nucleic acid by an enzyme from T4 bacteriophage-infected Escherichia coli.

Authors:  C C Richardson
Journal:  Proc Natl Acad Sci U S A       Date:  1965-07       Impact factor: 11.205

4.  Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

Authors:  G L Chen; L Yang; T C Rowe; B D Halligan; K M Tewey; L F Liu
Journal:  J Biol Chem       Date:  1984-11-10       Impact factor: 5.157

5.  Sequencing end-labeled DNA with base-specific chemical cleavages.

Authors:  A M Maxam; W Gilbert
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

6.  Specific labeling of 3' termini with T4 DNA polymerase.

Authors:  M D Challberg; P T Englund
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

7.  The enzymatic preparation of [alpha-32P]ATP, [alpha-32P]GTP, [32P]cAMP, and [32P]cGMP, and their use in the assay of adenylate and guanylate cyclases and cyclic nucleotide phosphodiesterases.

Authors:  R A Johnson; T F Walseth
Journal:  Adv Cyclic Nucleotide Res       Date:  1979

8.  Nalidixic acid resistance: a second genetic character involved in DNA gyrase activity.

Authors:  M Gellert; K Mizuuchi; M H O'Dea; T Itoh; J I Tomizawa
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

9.  Interaction between DNA and Escherichia coli protein omega. Formation of a complex between single-stranded DNA and omega protein.

Authors:  R E Depew; L F Liu; J C Wang
Journal:  J Biol Chem       Date:  1978-01-25       Impact factor: 5.157

10.  Qualitative and quantitative aspects of intercalator-induced DNA strand breaks.

Authors:  W E Ross; D Glaubiger; K W Kohn
Journal:  Biochim Biophys Acta       Date:  1979-03-28
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  81 in total

1.  Flanking nuclear matrix attachment regions synergize with the T cell receptor delta enhancer to promote V(D)J recombination.

Authors:  X P Zhong; J Carabaña; M S Krangel
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-12       Impact factor: 11.205

2.  Isolation of replicational cue elements from a library of bent DNAs of Aspergillus oryzae.

Authors:  T Kusakabe; Y Sugimoto; Y Hirota; S Toné; Y Kawaguchi; K Koga; T Ohyama
Journal:  Mol Biol Rep       Date:  2000-03       Impact factor: 2.316

3.  In silico prediction of scaffold/matrix attachment regions in large genomic sequences.

Authors:  Matthias Frisch; Kornelie Frech; Andreas Klingenhoff; Kerstin Cartharius; Ines Liebich; Thomas Werner
Journal:  Genome Res       Date:  2002-02       Impact factor: 9.043

4.  The efficiency of different IRESs (internal ribosomes entry site) in monocistronic mRNAS.

Authors:  J Attal; M C Théron; S Rival; C Puissant; L M Houdebine
Journal:  Mol Biol Rep       Date:  2000-03       Impact factor: 2.316

5.  Molecular characterization of the pericentric inversion that causes differences between chimpanzee chromosome 19 and human chromosome 17.

Authors:  Hildegard Kehrer-Sawatzki; Bettina Schreiner; Simone Tänzer; Matthias Platzer; Stefan Müller; Horst Hameister
Journal:  Am J Hum Genet       Date:  2002-07-01       Impact factor: 11.025

Review 6.  Topoisomerase II: its functions and phosphorylation.

Authors:  S M Gasser; R Walter; Q Dang; M E Cardenas
Journal:  Antonie Van Leeuwenhoek       Date:  1992-08       Impact factor: 2.271

7.  Stable heteroplasmy for a large-scale deletion in the coding region of Drosophila subobscura mitochondrial DNA.

Authors:  A Volz-Lingenhöhl; M Solignac; D Sperlich
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-01       Impact factor: 11.205

8.  The recognition of DNA cleavage sites by porcine spleen topoisomerase II.

Authors:  H W Huang; J K Juang; H J Liu
Journal:  Nucleic Acids Res       Date:  1992-02-11       Impact factor: 16.971

9.  Development of a heat shock inducible expression cassette for plants: characterization of parameters for its use in transient expression assays.

Authors:  W M Ainley; J L Key
Journal:  Plant Mol Biol       Date:  1990-06       Impact factor: 4.076

10.  Locations and contexts of sequences that hybridize to poly(dG-dT).(dC-dA) in mammalian ribosomal DNAs and two X-linked genes.

Authors:  D C Braaten; J R Thomas; R D Little; K R Dickson; I Goldberg; D Schlessinger; A Ciccodicola; M D'Urso
Journal:  Nucleic Acids Res       Date:  1988-02-11       Impact factor: 16.971
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