Literature DB >> 2987605

Cytomegalovirus DNA in colorectal carcinoma tissues.

R Rüger, B Fleckenstein.   

Abstract

Numerous studies had linked human cytomegalovirus (HCMV) infections with neoplasia. Among various other malignant tumors, colonic carcinoma tissues were reported to contain DNA sequences hybridizing with DNA extracted from virus particles. Gene technology allowed us to use a cloned viral DNA library to measure HCMV in colorectal tumors more specifically. Four of 38 tissue specimens did contain DNA sequences homologous to cloned viral DNA probes; however, in each of those cases, identical hybridization patterns were seen with specimens from non-infiltrated surrounding intestinal wall. The amount of HCMV DNA in normal tissues was at least as much as in tumor biopsies. We conclude that nucleic acid hybridizations at high sensitivity with moleculary cloned HCMV DNA did not support the notion of a correlation between colorectal carcinomas and human cytomegalovirus.

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Year:  1985        PMID： 2987605     DOI： 10.1007/bf01733665

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN： 0023-2173


  18 in total

1.  Cytomegalovirus isolations from cell cultures of human adenocarcinomas of the colon.

Authors:  G M Hashiro; S Horikami; P C Loh
Journal:  Intervirology       Date:  1979       Impact factor: 1.763

2.  Association of cytomegalovirus (CMV) infection with cervical cancer: isolation of CMV from cell cultures derived from cervical biopsy.

Authors:  J L Melnick; R Lewis; I Wimberly; R H Kaufman; E Adam
Journal:  Intervirology       Date:  1978       Impact factor: 1.763

3.  Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.

Authors:  P W Rigby; M Dieckmann; C Rhodes; P Berg
Journal:  J Mol Biol       Date:  1977-06-15       Impact factor: 5.469

4.  Transformation of NIH 3T3 cells with cloned fragments of human cytomegalovirus strain AD169.

Authors:  J A Nelson; B Fleckenstein; D A Galloway; J K McDougall
Journal:  J Virol       Date:  1982-07       Impact factor: 5.103

5.  Structure of the transforming region of human cytomegalovirus AD169.

Authors:  J A Nelson; B Fleckenstein; G Jahn; D A Galloway; J K McDougall
Journal:  J Virol       Date:  1984-01       Impact factor: 5.103

6.  Predominant immediate-early transcripts of human cytomegalovirus AD 169.

Authors:  G Jahn; E Knust; H Schmolla; T Sarre; J A Nelson; J K McDougall; B Fleckenstein
Journal:  J Virol       Date:  1984-02       Impact factor: 5.103

7.  Cloning of the complete human cytomegalovirus genome in cosmids.

Authors:  B Fleckenstein; I Müller; J Collins
Journal:  Gene       Date:  1982-04       Impact factor: 3.688

8.  Cytomegalovirus: detection in human colonic and circulating mononuclear cells in association with gastrointestinal disease.

Authors:  J K Roche; K S Cheung; I Boldogh; E S Huang; D J Lang
Journal:  Int J Cancer       Date:  1981-05-15       Impact factor: 7.396

9.  Kaposi's sarcoma. IV. Detection of CMV DNA, CMV RNA and CMNA in tumor biopsies.

Authors:  I Boldogh; E Beth; E S Huang; S K Kyalwazi; G Giraldo
Journal:  Int J Cancer       Date:  1981-10-15       Impact factor: 7.396

10.  Cytomegalovirus D.N.A. and adenocarcinoma of the colon: Evidence for latent viral infection.

Authors:  E S Huang; J K Roche
Journal:  Lancet       Date:  1978-05-06       Impact factor: 79.321
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  4 in total

1.  The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice.

Authors:  Gerold Bongers; David Maussang; Luciana R Muniz; Vanessa M Noriega; Alberto Fraile-Ramos; Nick Barker; Federica Marchesi; Nanthakumar Thirunarayanan; Henry F Vischer; Lihui Qin; Lloyd Mayer; Noam Harpaz; Rob Leurs; Glaucia C Furtado; Hans Clevers; Domenico Tortorella; Martine J Smit; Sergio A Lira
Journal:  J Clin Invest       Date:  2010-10-11       Impact factor: 14.808

2.  In situ hybridization for the detection of cytomegalovirus (CMV) infection. Application of biotinylated CMV-DNA probes on paraffin-embedded specimens.

Authors:  T Löning; K Milde; H D Foss
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1986

3.  Human cytomegalovirus DNA in the temporal cortex of a schizophrenic patient.

Authors:  H W Moises; R Rüger; G P Reynolds; B Fleckenstein
Journal:  Eur Arch Psychiatry Neurol Sci       Date:  1988

4.  Analysis of colorectal cancers for human cytomegalovirus presence.

Authors:  Cecilia Bender; Donato Zipeto; Carlo Bidoia; Silvia Costantini; Alberto Zamò; Fabio Menestrina; Umberto Bertazzoni
Journal:  Infect Agent Cancer       Date:  2009-04-16       Impact factor: 2.965
  4 in total

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