Luke J Peterson1, Janelle K Kirsch1, John P Wolfe1. 1. Department of Chemistry , University of Michigan , 930 North University Avenue , Ann Arbor , Michigan 48109-1055 , United States.
Abstract
The Pd-catalyzed coupling of N-allylguanidines or N-allylureas with O-benzoylhydroxylamine derivatives affords cyclic guanidines or cyclic ureas bearing dialkylaminomethyl groups. The desired products are obtained in good yield, and substrates bearing substituents at the allylic position are transformed with moderate diastereoselectivity. The mechanism of these reactions appears to involve anti-aminopalladation of the alkene, followed by a rare sp3C-sp3N bond-forming reductive elimination from an alkylpalladium complex that contains β-hydrogen atoms.
The Pd-catalyzed coupling of n class="Disease">N-allylguanidines or N-allylureas with O-benzoylhydroxylamine derivatives affords cyclic guanidines or cyclic ureas bearing dialkylaminomethyl groups. The desired products are obtained in good yield, and substrates bearing substituents at the allylic position are transformed with moderate diastereoselectivity. The mechanism of these reactions appears to involve anti-aminopalladation of the alkene, followed by a rare sp3C-sp3N bond-forming reductive elimination from an alkylpalladium complex that contains β-hydrogen atoms.
Authors: Jodie L Brice; Jenna E Harang; Vitaliy I Timokhin; Natia R Anastasi; Shannon S Stahl Journal: J Am Chem Soc Date: 2005-03-09 Impact factor: 15.419