Literature DB >> 16737306

A new synthesis of imidazolidin-2-ones via Pd-catalyzed carboamination of N-allylureas.

Jonathan A Fritz1, Josephine S Nakhla, John P Wolfe.   

Abstract

A new strategy for the preparation of substituted imidazolidin-2-ones in two steps from readily available N-allylamines is described. Addition of the amine starting materials to isocyanates affords N-allylureas, which are converted to imidazolidin-2-one products with generation of two bonds and up to two stereocenters when treated with aryl bromides and catalytic amounts of Pd2(dba)3/Xantphos in the presence of NaO(t)Bu. [reaction: see text]

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Year:  2006        PMID： 16737306      PMCID： PMC2527974          DOI： 10.1021/ol060707b

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  16 in total

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  24 in total

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8.  Stereoselective Synthesis of Saturated Heterocycles via Pd-Catalyzed Alkene Carboetherification and Carboamination Reactions.

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