Jenna L Riis1, Crystal I Bryce1,2, Marla J Matin3, John L Stebbins3, Olga Kornienko1,4, Lauren van Huisstede2, Douglas A Granger1,5,6,7,8. 1. Institute for Interdisciplinary Salivary Bioscience Research, University of California at Irvine, Irvine, CA 92697, USA. 2. T. Denny Sanford School of Social & Family Dynamics, Arizona State University, Tempe, AZ 85287, USA. 3. Research & Technology Center, Salimetrics, Carlsbad, CA 92008, USA. 4. Department of Psychology, George Mason University, Fairfax, VA 22030, USA. 5. Department of Population, Family, & Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA. 6. Department of Acute & Chronic Care, Johns Hopkins University School of Nursing, Baltimore, MD 21205, USA. 7. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. 8. Salivary Bioscience Laboratory & Department of Psychology, University of Nebraska, Lincoln, NE 68588, USA.
Abstract
AIM: Serum uric acid (UA) is associated with many health conditions, including kidney, cardiovascular, and metabolic disorders. We examined the validity and stability of salivary UA as a noninvasive measure of serum UA. MATERIALS & METHODS: Using serum and salivary UA data from healthy adults (n = 99), we examined the UA serum-saliva correlation, and UA associations with adiponectin and C-reactive protein. Using longitudinal data from young adults (n = 182), we examined salivary UA stability. RESULTS: We found robust positive serum-saliva correlations for UA. UA and adiponectin were inversely related in serum and saliva. Salivary UA was relatively stable; 62-66% of variance could be attributed to a latent trait-like component. CONCLUSION: Salivary UA may be an important biomarker indexing health and disease risk.
AIM: Serum uric acid (UA) is associated with many health conditions, including kidney, cardiovascular, and metabolic disorders. We examined the validity and stability of salivary UA as a noninvasive measure of serum UA. MATERIALS & METHODS: Using serum and salivary UA data from healthy adults (n = 99), we examined the UA serum-saliva correlation, and UA associations with adiponectin and C-reactive protein. Using longitudinal data from young adults (n = 182), we examined salivary UA stability. RESULTS: We found robust positive serum-saliva correlations for UA. UA and adiponectin were inversely related in serum and saliva. Salivary UA was relatively stable; 62-66% of variance could be attributed to a latent trait-like component. CONCLUSION: Salivary UA may be an important biomarker indexing health and disease risk.
Entities:
Keywords:
C-reactive protein; adiponectin; biomarker; body mass index; latent state-trait modeling; saliva; serum; uric acid
Authors: Thomas A Pearson; George A Mensah; R Wayne Alexander; Jeffrey L Anderson; Richard O Cannon; Michael Criqui; Yazid Y Fadl; Stephen P Fortmann; Yuling Hong; Gary L Myers; Nader Rifai; Sidney C Smith; Kathryn Taubert; Russell P Tracy; Frank Vinicor Journal: Circulation Date: 2003-01-28 Impact factor: 29.690
Authors: Leo K Niskanen; David E Laaksonen; Kristiina Nyyssönen; Georg Alfthan; Hanna-Maaria Lakka; Timo A Lakka; Jukka T Salonen Journal: Arch Intern Med Date: 2004-07-26
Authors: P Rinaldi; M C Polidori; A Metastasio; E Mariani; P Mattioli; A Cherubini; M Catani; R Cecchetti; U Senin; P Mecocci Journal: Neurobiol Aging Date: 2003-11 Impact factor: 4.673
Authors: Katie T Kivlighan; Douglas A Granger; Eve B Schwartz; Vincent Nelson; Mary Curran; Elizabeth A Shirtcliff Journal: Horm Behav Date: 2004-06 Impact factor: 3.587
Authors: Jenna L Riis; Hedyeh Ahmadi; Katrina R Hamilton; Crystal I Bryce; Clancy Blair; Douglas A Granger Journal: Psychoneuroendocrinology Date: 2021-03-17 Impact factor: 4.905
Authors: Jorge M González-Hernández; Lorena Franco; David Colomer-Poveda; Silvia Martinez-Subiela; Ramón Cugat; José J Cerón; Gonzalo Márquez; Luis M Martínez-Aranda; Pedro Jimenez-Reyes; Asta Tvarijonaviciute Journal: Antioxidants (Basel) Date: 2019-09-11
Authors: Jody Corey-Bloom; Ameera Haque; Sameer Aboufadel; Chase Snell; Ryan S Fischer; Steven W Granger; Douglas A Granger; Elizabeth A Thomas Journal: Front Neurosci Date: 2020-03-04 Impact factor: 4.677