L Zakarin Safier1, A Gumer1, M Kline1, D Egli2,3, M V Sauer1,4,5. 1. Center for Women's Reproductive Care, Columbia University Medical Center, New York, NY, USA. 2. Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY, USA. de2220@cumc.columbia.edu. 3. Department of Pediatrics, Columbia University Medical Center, New York, NY, USA. de2220@cumc.columbia.edu. 4. Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY, USA. 5. Robert Wood Johnson Medical School, Rutgers University, Brunswick, NJ, USA.
Abstract
PURPOSE: Human oocytes are arguably one of the most important cell types in humans, yet they are one of the least investigated cells. Because oocytes are limited in number, the use of high-quality oocytes is almost entirely in reproduction. Furthermore, regulatory hurdles for research on gametes and regulations on funding related to research on gametes present significant obstacles to research and the advancement of reproductive treatments. Here we report the outcomes of the largest compensated oocyte donation program for research in the USA to date, and probably worldwide. METHODS: Women who participated in oocyte donation for research between 2008 and 2017 were contacted in a phone interview and completed a standardized questionnaire. RESULTS: Of 114 participants, 98 oocyte donors completed donation, donating 1787 mature MII oocytes and a total of 86 skin biopsies. Complication rate, including minor complications, of oocyte donation was 8/98, or 8.1%, for which two involved follow-up. Fifty-seven donors answered questions about their experience. Participants were incentivized primarily by money and a desire to help others and reported an overall favorable experience. Most, but not all, human subjects recalled that they had donated for research, and approximately half recalled that their oocytes were being used specifically for stem cell research. CONCLUSIONS: Compensated oocyte donation provides a reliable path to obtaining high-quality oocytes for research and is reviewed favorably by oocyte donors. The continuation of programs that offer compensation for oocyte donation is invaluable to continued progress and advancements in stem cell research and human embryology, and for the advancement of novel reproductive treatments.
PURPOSE:Human oocytes are arguably one of the most important cell types in humans, yet they are one of the least investigated cells. Because oocytes are limited in number, the use of high-quality oocytes is almost entirely in reproduction. Furthermore, regulatory hurdles for research on gametes and regulations on funding related to research on gametes present significant obstacles to research and the advancement of reproductive treatments. Here we report the outcomes of the largest compensated oocyte donation program for research in the USA to date, and probably worldwide. METHODS:Women who participated in oocyte donation for research between 2008 and 2017 were contacted in a phone interview and completed a standardized questionnaire. RESULTS: Of 114 participants, 98 oocyte donors completed donation, donating 1787 mature MII oocytes and a total of 86 skin biopsies. Complication rate, including minor complications, of oocyte donation was 8/98, or 8.1%, for which two involved follow-up. Fifty-seven donors answered questions about their experience. Participants were incentivized primarily by money and a desire to help others and reported an overall favorable experience. Most, but not all, human subjects recalled that they had donated for research, and approximately half recalled that their oocytes were being used specifically for stem cell research. CONCLUSIONS: Compensated oocyte donation provides a reliable path to obtaining high-quality oocytes for research and is reviewed favorably by oocyte donors. The continuation of programs that offer compensation for oocyte donation is invaluable to continued progress and advancements in stem cell research and human embryology, and for the advancement of novel reproductive treatments.
Authors: Daniel H Kort; Gloryn Chia; Nathan R Treff; Akemi J Tanaka; Tongji Xing; Lauren Bauer Vensand; Stephanie Micucci; Robert Prosser; Roger A Lobo; Mark V Sauer; Dieter Egli Journal: Hum Reprod Date: 2015-11-29 Impact factor: 6.918
Authors: Scott Noggle; Ho-Lim Fung; Athurva Gore; Hector Martinez; Kathleen Crumm Satriani; Robert Prosser; Kiboong Oum; Daniel Paull; Sarah Druckenmiller; Matthew Freeby; Ellen Greenberg; Kun Zhang; Robin Goland; Mark V Sauer; Rudolph L Leibel; Dieter Egli Journal: Nature Date: 2011-10-05 Impact factor: 49.962
Authors: Mitsutoshi Yamada; Bjarki Johannesson; Ido Sagi; Lisa Cole Burnett; Daniel H Kort; Robert W Prosser; Daniel Paull; Michael W Nestor; Matthew Freeby; Ellen Greenberg; Robin S Goland; Rudolph L Leibel; Susan L Solomon; Nissim Benvenisty; Mark V Sauer; Dieter Egli Journal: Nature Date: 2014-04-28 Impact factor: 49.962
Authors: Daniel Paull; Valentina Emmanuele; Keren A Weiss; Nathan Treff; Latoya Stewart; Haiqing Hua; Matthew Zimmer; David J Kahler; Robin S Goland; Scott A Noggle; Robert Prosser; Michio Hirano; Mark V Sauer; Dieter Egli Journal: Nature Date: 2012-12-19 Impact factor: 49.962
Authors: Hong Ma; Ryan C O'Neil; Nuria Marti Gutierrez; Manoj Hariharan; Zhuzhu Z Zhang; Yupeng He; Cengiz Cinnioglu; Refik Kayali; Eunju Kang; Yeonmi Lee; Tomonari Hayama; Amy Koski; Joseph Nery; Rosa Castanon; Rebecca Tippner-Hedges; Riffat Ahmed; Crystal Van Dyken; Ying Li; Susan Olson; David Battaglia; David M Lee; Diana H Wu; Paula Amato; Don P Wolf; Joseph R Ecker; Shoukhrat Mitalipov Journal: Cell Stem Cell Date: 2016-11-10 Impact factor: 24.633