Literature DB >> 2987134

Erythrocyte pyrimidine 5'-nucleotidase activity in workers exposed to lead, mercury or cadmium.

B Mohammed-Brahim, J P Buchet, R Lauwerys.   

Abstract

The erythrocyte pyrimidine 5'-nucleotidase activity (P5N) was measured in workers exposed to lead, cadmium or inorganic mercury and the effect of lead on this enzyme activity was compared with that on the classical biological parameters (ALAD, ZPP, ALAU), reflecting the interference of this metal with the heme biosynthesis pathway. P5N is inhibited by lead but not by cadmium and mercury. The correlation coefficient between log P5N and lead in blood (PbB) amount to 0.79 (n = 278; PbB ranging from 4.9 to 73.5 micrograms/100 ml). The response of P5N to lead closely parallels that of ALAD.

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Year:  1985        PMID： 2987134     DOI： 10.1007/bf00383757

Source DB:  PubMed          Journal:  Int Arch Occup Environ Health        ISSN： 0340-0131            Impact factor:   3.015


  16 in total

1.  Effects of low-level lead exposure on pyrimidine 5'-nucleotidase and other erythrocyte enzymes. Possible role of pyrimidine 5'-nucleotidase in the pathogenesis of lead-induced anemia.

Authors:  D E Paglia; W N Valentine; J G Dahlgren
Journal:  J Clin Invest       Date:  1975-11       Impact factor: 14.808

2.  European standardized method for the determination of delta-aminolevulinic acid dehydratase activity in blood.

Authors:  A Berlin; K H Schaller
Journal:  Z Klin Chem Klin Biochem       Date:  1974-08

3.  Relationship between urinary delta-aminolevulinic acid excretion and the inhibition of red cell delta-aminolevulinate dehydratase by lead.

Authors:  R Lauwerys; J P Buchet; H A Roels; D Materne
Journal:  Clin Toxicol       Date:  1974       Impact factor: 4.467

4.  Automated analysis of delta-aminolaevulinic acid in urine.

Authors:  R Lauwerys; R Delbroeck; M D Vens
Journal:  Clin Chim Acta       Date:  1972-09       Impact factor: 3.786

5.  [The infraclinical diagnosis of lead poisoning (author's transl)].

Authors:  J P Fendler; G Dongradi; H A Buc
Journal:  Ann Med Interne (Paris)       Date:  1978 Aug-Sep

6.  Restoration of lead-inhibited 5-aminolevulinate dehydratase activity in whole blood by heat, zinc ion, and (or) dithiothreitol.

Authors:  T Sakai; S Yanagihara; K Ushio
Journal:  Clin Chem       Date:  1980-04       Impact factor: 8.327

7.  Red-cell pyrimidine 5'-nucleotidase and lead poisoning.

Authors:  H A Buc; J C Kaplan
Journal:  Clin Chim Acta       Date:  1978-07-01       Impact factor: 3.786

8.  Lead poisoning. Further observations on erythrocyte pyrimidine-nucleotidase deficiency and intracellular accumulation of pyrimidine nucleotides.

Authors:  D E Paglia; W N Valentine; K Fink
Journal:  J Clin Invest       Date:  1977-12       Impact factor: 14.808

9.  In vitro effects of lead, mercury and cadmium on the enzymic activity of red-blood cell pyrimidine 5'-nucleotidase.

Authors:  B Mohammed-Brahim; J P Buchet; A Bernard; R Lauwerys
Journal:  Toxicol Lett       Date:  1984-02       Impact factor: 4.372

10.  Relationship between lead concentration in blood and the activities of erythrocyte pyrimidine 5'-nucleotidase and delta-aminolevulinate dehydratase in the mice exposed to lead.

Authors:  K Tomokuni; M Ogata
Journal:  Arch Toxicol       Date:  1981-03       Impact factor: 5.153
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  7 in total

1.  Response of erythrocyte pyrimidine 5'-nucleotidase (P5N) activity in workers exposed to lead.

Authors:  M Ichiba; K Tomokuni
Journal:  Br J Ind Med       Date:  1988-10

2.  A simplified method for determining erythrocyte pyrimidine 5'-nucleotidase (P5N) activity by HPLC and its value in monitoring lead exposure.

Authors:  T Sakai; K Ushio
Journal:  Br J Ind Med       Date:  1986-12

3.  Relationship between inhibition of erythrocyte pyrimidine 5'-nucleotidase activity and biological response for porphyrin metabolism in workers occupationally exposed to lead.

Authors:  K Tomokuni; M Ichiba; Y Hirai; T Hasegawa; K Sugimoto
Journal:  Int Arch Occup Environ Health       Date:  1988       Impact factor: 3.015

4.  Effect of lead exposure on some biological indices related to porphyrin metabolism and the activity of erythrocyte pyrimidine 5'-nucleotidase in the mice.

Authors:  K Tomokuni; M Ichiba; Y Hirai
Journal:  Arch Toxicol       Date:  1989       Impact factor: 5.153

5.  Erythrocyte nucleotides in lead workers.

Authors:  M Ichiba; K Tomokuni; K Mori
Journal:  Int Arch Occup Environ Health       Date:  1992       Impact factor: 3.015

6.  Evaluation of lead exposure in workers at a lead-acid battery factory in Korea: with focus on activity of erythrocyte pyrimidine 5'-nucleotidase (P5N).

Authors:  Y Kim; K Harada; S Ohmori; B K Lee; H Miura; A Ueda
Journal:  Occup Environ Med       Date:  1995-07       Impact factor: 4.402

7.  Studies on erythrocyte pyrimidine 5'-nucleotidase (P5N) test and its evaluation in workers occupationally exposed to lead.

Authors:  M Ichiba; K Tomokuni
Journal:  Int Arch Occup Environ Health       Date:  1990       Impact factor: 3.015
  7 in total

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