Jennifer A A DeLuca1, Erika L Garcia-Villatoro1, Clinton D Allred2. 1. Department of Nutrition and Food Science, Texas A&M University, 2253 TAMU, 373 Olsen Blvd, College Station, TX, 77843, USA. 2. Department of Nutrition and Food Science, Texas A&M University, 2253 TAMU, 373 Olsen Blvd, College Station, TX, 77843, USA. callred@tamu.edu.
Abstract
PURPOSE OF REVIEW: Flaxseed and its bioactive components have been associated with a decreased risk of colorectal cancer incidence and progression. This review aims to summarize recent research regarding the role of flaxseed and each of its major dietary bioactive components in reducing colorectal cancer. RECENT FINDINGS: In both human and animal model experiments, flaxseed consumption had beneficial effects on colon physiology associated with reduction in colorectal cancer risk or occurrence. Considered separately, each of flaxseed's major bioactive components, including fiber, alpha-linolenic acid, lignans, and other phytochemicals, is also associated with decreased risk of colonic neoplasms and regulation of cell growth through several potential mechanisms. Collectively, experimental data suggests that consumption of flaxseed and/or its bioactive components may reduce colorectal cancer risk by a variety of mechanisms. Future studies should focus on the mechanisms by which whole flaxseed can prevent colorectal cancer.
PURPOSE OF REVIEW: Flaxseed and its bioactive components have been associated with a decreased risk of colorectal cancer incidence and progression. This review aims to summarize recent research regarding the role of flaxseed and each of its major dietary bioactive components in reducing colorectal cancer. RECENT FINDINGS: In both human and animal model experiments, flaxseed consumption had beneficial effects on colon physiology associated with reduction in colorectal cancer risk or occurrence. Considered separately, each of flaxseed's major bioactive components, including fiber, alpha-linolenic acid, lignans, and other phytochemicals, is also associated with decreased risk of colonic neoplasms and regulation of cell growth through several potential mechanisms. Collectively, experimental data suggests that consumption of flaxseed and/or its bioactive components may reduce colorectal cancer risk by a variety of mechanisms. Future studies should focus on the mechanisms by which whole flaxseed can prevent colorectal cancer.
Authors: Anneleen Kuijsten; Ilja C W Arts; Peter C H Hollman; Pieter van't Veer; Ellen Kampman Journal: Cancer Epidemiol Biomarkers Prev Date: 2006-06 Impact factor: 4.254
Authors: F Fernández-Bañares; M Esteve; E Navarro; E Cabré; J Boix; A Abad-Lacruz; J Klaassen; R Planas; P Humbert; C Pastor; M A Gassull Journal: Gut Date: 1996-02 Impact factor: 23.059
Authors: Annika I Smeds; Kristo Hakala; Teija T Hurmerinta; Liisi Kortela; Niina M Saarinen; Sari I Mäkelä Journal: J Pharm Biomed Anal Date: 2006-02-07 Impact factor: 3.935
Authors: Oleg Shadyro; Anna Sosnovskaya; Irina Edimecheva; Lana Ihnatovich; Boris Dubovik; Sergei Krasny; Dmitry Tzerkovsky; Egor Protopovich Journal: Front Pharmacol Date: 2022-06-21 Impact factor: 5.988
Authors: Md Sanower Hossain; Md Abdul Kader; Khang Wen Goh; Maidul Islam; Md Sharif Khan; Md Harun-Ar Rashid; Der Jiun Ooi; Henrique Douglas Melo Coutinho; Yaser Mohammed Al-Worafi; Said Moshawih; Ya Chee Lim; K M Kaderi Kibria; Long Chiau Ming Journal: Front Pharmacol Date: 2022-06-30 Impact factor: 5.988
Authors: Md Sanower Hossain; Hidayah Karuniawati; Ammar Abdulrahman Jairoun; Zannat Urbi; Der Jiun Ooi; Akbar John; Ya Chee Lim; K M Kaderi Kibria; A K M Mohiuddin; Long Chiau Ming; Khang Wen Goh; Muhammad Abdul Hadi Journal: Cancers (Basel) Date: 2022-03-29 Impact factor: 6.639