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Literature DB >> 29866865

Activities of Oxadiazole Antibacterials against Staphylococcus aureus and Other Gram-Positive Bacteria.

Sara Ceballos¹, Choon Kim², Derong Ding², Shahriar Mobashery², Mayland Chang³, Carmen Torres⁴.

Abstract

The activities of four oxadiazoles were investigated with 210 methicillin-resistant Staphylococcus aureus (MRSA) strains. MIC50 and MIC90 values of 1 to 2 and 4 μg/ml, respectively, were observed. We also evaluated the activity of oxadiazole ND-421 against other staphylococci and enterococci and in the presence of oxacillin for selected MRSA strains. The MIC for ND-421 is lowered severalfold in combination with oxacillin, as they synergize. The MIC90 of ND-421 against vancomycin-resistant enterococci is ≤1 μg/ml.

Entities: Chemical Species

Keywords: Enterococcus; MIC; MRSA; PBPs; Staphylococcus spp.; oxadiazole

Mesh：

Substances：

Year: 2018 PMID： 29866865 PMCID： PMC6105842 DOI： 10.1128/AAC.00453-18

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

13 in total

1. Detection of staphylococcal cassette chromosome mec type XI carrying highly divergent mecA, mecI, mecR1, blaZ, and ccr genes in human clinical isolates of clonal complex 130 methicillin-resistant Staphylococcus aureus.

Authors: Anna C Shore; Emily C Deasy; Peter Slickers; Grainne Brennan; Brian O'Connell; Stefan Monecke; Ralf Ehricht; David C Coleman
Journal: Antimicrob Agents Chemother Date: 2011-06-02 Impact factor: 5.191

Review 2. Penicillin binding proteins: key players in bacterial cell cycle and drug resistance processes.

Authors: Pauline Macheboeuf; Carlos Contreras-Martel; Viviana Job; Otto Dideberg; Andréa Dessen
Journal: FEMS Microbiol Rev Date: 2006-09 Impact factor: 16.408

3. How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function.

Authors: Lisandro H Otero; Alzoray Rojas-Altuve; Leticia I Llarrull; Cesar Carrasco-López; Malika Kumarasiri; Elena Lastochkin; Jennifer Fishovitz; Matthew Dawley; Dusan Hesek; Mijoon Lee; Jarrod W Johnson; Jed F Fisher; Mayland Chang; Shahriar Mobashery; Juan A Hermoso
Journal: Proc Natl Acad Sci U S A Date: 2013-10-01 Impact factor: 11.205

4. In vitro activity of ceftaroline against clinical Staphylococcus aureus isolates collected during a national survey conducted in Belgian hospitals.

Authors: M Angeles Argudín; M Dodémont; M Taguemount; S Roisin; R de Mendonça; A Deplano; C Nonhoff; O Denis
Journal: J Antimicrob Chemother Date: 2016-09-15 Impact factor: 5.790

5. In Vitro and In Vivo Synergy of the Oxadiazole Class of Antibacterials with β-Lactams.

Authors: Jeshina Janardhanan; Jayda E Meisel; Derong Ding; Valerie A Schroeder; William R Wolter; Shahriar Mobashery; Mayland Chang
Journal: Antimicrob Agents Chemother Date: 2016-08-22 Impact factor: 5.191

6. Missense mutations in PBP2A Affecting ceftaroline susceptibility detected in epidemic hospital-acquired methicillin-resistant Staphylococcus aureus clonotypes ST228 and ST247 in Western Switzerland archived since 1998.

Authors: William L Kelley; Ambre Jousselin; Christine Barras; Emmanuelle Lelong; Adriana Renzoni
Journal: Antimicrob Agents Chemother Date: 2015-01-12 Impact factor: 5.191

7. Exploration of the structure-activity relationship of 1,2,4-oxadiazole antibiotics.

Authors: Derong Ding; Marc A Boudreau; Erika Leemans; Edward Spink; Takao Yamaguchi; Sebastian A Testero; Peter I O'Daniel; Elena Lastochkin; Mayland Chang; Shahriar Mobashery
Journal: Bioorg Med Chem Lett Date: 2015-06-18 Impact factor: 2.823

8. Structure-activity relationship for the oxadiazole class of antibiotics.

Authors: Edward Spink; Derong Ding; Zhihong Peng; Marc A Boudreau; Erika Leemans; Elena Lastochkin; Wei Song; Katerina Lichtenwalter; Peter I O'Daniel; Sebastian A Testero; Hualiang Pi; Valerie A Schroeder; William R Wolter; Nuno T Antunes; Mark A Suckow; Sergei Vakulenko; Mayland Chang; Shahriar Mobashery
Journal: J Med Chem Date: 2015-01-30 Impact factor: 7.446

Activities of Oxadiazole Antibacterials against Staphylococcus aureus and Other Gram-Positive Bacteria.

1. Detection of staphylococcal cassette chromosome mec type XI carrying highly divergent mecA, mecI, mecR1, blaZ, and ccr genes in human clinical isolates of clonal complex 130 methicillin-resistant Staphylococcus aureus.

Review 2. Penicillin binding proteins: key players in bacterial cell cycle and drug resistance processes.

3. How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function.

4. In vitro activity of ceftaroline against clinical Staphylococcus aureus isolates collected during a national survey conducted in Belgian hospitals.

5. In Vitro and In Vivo Synergy of the Oxadiazole Class of Antibacterials with β-Lactams.

6. Missense mutations in PBP2A Affecting ceftaroline susceptibility detected in epidemic hospital-acquired methicillin-resistant Staphylococcus aureus clonotypes ST228 and ST247 in Western Switzerland archived since 1998.

7. Exploration of the structure-activity relationship of 1,2,4-oxadiazole antibiotics.

8. Structure-activity relationship for the oxadiazole class of antibiotics.

Review 9. Penicillin-binding proteins and beta-lactam resistance.

Review 10. The emergence of mecC methicillin-resistant Staphylococcus aureus.

Review 1. Constructing and deconstructing the bacterial cell wall.

2. Unconventional Antibacterials and Adjuvants.