Literature DB >> 29866857

Genetic and Biochemical Characterization of OXA-519, a Novel OXA-48-Like β-Lactamase.

Laura Dabos1,2, Pierre Bogaerts3,4, Remy A Bonnin1,2,5, Agustin Zavala6, Pierre Sacré3,4, Bogdan I Iorga6, Daniel T Huang3,4, Youri Glupczynski3,4, Thierry Naas7,2,5,8.   

Abstract

A multidrug-resistant Klebsiella pneumoniae 1210 isolate with reduced carbapenem susceptibility revealed the presence of a novel plasmid-encoded blaOXA-48-like gene, named blaOXA-519 The 60.7-kb plasmid (pOXA-519) was similar to the IncL-OXA-48 prototypical plasmid except for a ca. 2-kb deletion due to an IS1R insertion. OXA-519 differed from OXA-48 by a Val120Leu substitution, which resulted in an overall reduced β-lactam-hydrolysis profile, except those for ertapenem and meropenem, which were increased. Thus, detection of OXA-519 producers using biochemical tests that monitor imipenem hydrolysis will be difficult.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  OXA-48 like; carbapenemase; detection; mutant; steady-state kinetics

Mesh：

Substances：

Year:  2018        PMID： 29866857      PMCID： PMC6105830          DOI： 10.1128/AAC.00469-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  34 in total

Review 1.  Genetic support and diversity of acquired extended-spectrum β-lactamases in Gram-negative rods.

Authors:  Laurent Poirel; Rémy A Bonnin; Patrice Nordmann
Journal:  Infect Genet Evol       Date:  2012-03-03       Impact factor: 3.342

2.  Evaluation of the BYG Carba Test, a New Electrochemical Assay for Rapid Laboratory Detection of Carbapenemase-Producing Enterobacteriaceae.

Authors:  Pierre Bogaerts; Sami Yunus; Marion Massart; Te-Din Huang; Youri Glupczynski
Journal:  J Clin Microbiol       Date:  2015-12-04       Impact factor: 5.948

3.  Functional characterization of IS1999, an IS4 family element involved in mobilization and expression of beta-lactam resistance genes.

Authors:  Daniel Aubert; Thierry Naas; Claire Héritier; Laurent Poirel; Patrice Nordmann
Journal:  J Bacteriol       Date:  2006-09       Impact factor: 3.490

4.  Characterization of OXA-181, a carbapenem-hydrolyzing class D beta-lactamase from Klebsiella pneumoniae.

Authors:  Anaïs Potron; Patrice Nordmann; Emilie Lafeuille; Zaina Al Maskari; Fatma Al Rashdi; Laurent Poirel
Journal:  Antimicrob Agents Chemother       Date:  2011-07-18       Impact factor: 5.191

5.  Genetic and biochemical characterisation of OXA-232, a carbapenem-hydrolysing class D β-lactamase from Enterobacteriaceae.

Authors:  Anaïs Potron; Emilie Rondinaud; Laurent Poirel; Olivier Belmonte; Sophie Boyer; Sabine Camiade; Patrice Nordmann
Journal:  Int J Antimicrob Agents       Date:  2013-01-08       Impact factor: 5.283

6.  Identification of acquired antimicrobial resistance genes.

Authors:  Ea Zankari; Henrik Hasman; Salvatore Cosentino; Martin Vestergaard; Simon Rasmussen; Ole Lund; Frank M Aarestrup; Mette Voldby Larsen
Journal:  J Antimicrob Chemother       Date:  2012-07-10       Impact factor: 5.790

Review 7.  Mechanism of action of and resistance to quinolones.

Authors:  Anna Fàbrega; Sergi Madurga; Ernest Giralt; Jordi Vila
Journal:  Microb Biotechnol       Date:  2008-10-13       Impact factor: 5.813

8.  A multiplex lateral flow immunoassay for the rapid identification of NDM-, KPC-, IMP- and VIM-type and OXA-48-like carbapenemase-producing Enterobacteriaceae.

Authors:  Hervé Boutal; Anaïs Vogel; Sandrine Bernabeu; Karine Devilliers; Elodie Creton; Garence Cotellon; Marc Plaisance; Saoussen Oueslati; Laurent Dortet; Agnès Jousset; Stéphanie Simon; Thierry Naas; Hervé Volland
Journal:  J Antimicrob Chemother       Date:  2018-04-01       Impact factor: 5.790

9.  Beta-lactamase database (BLDB) - structure and function.

Authors:  Thierry Naas; Saoussen Oueslati; Rémy A Bonnin; Maria Laura Dabos; Agustin Zavala; Laurent Dortet; Pascal Retailleau; Bogdan I Iorga
Journal:  J Enzyme Inhib Med Chem       Date:  2017-12       Impact factor: 5.051

10.  KPC-3-Producing Klebsiella pneumoniae in Portugal Linked to Previously Circulating Non-CG258 Lineages and Uncommon Genetic Platforms (Tn4401d-IncFIA and Tn4401d-IncN).

Authors:  Carla Rodrigues; Jan Bavlovič; Elisabete Machado; José Amorim; Luísa Peixe; Ângela Novais
Journal:  Front Microbiol       Date:  2016-06-28       Impact factor: 5.640
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  13 in total

1.  Improvement of the Immunochromatographic NG-Test Carba 5 Assay for the Detection of IMP Variants Previously Undetected.

Authors:  Hervé Volland; Delphine Girlich; Marine Laguide; Camille Gonzalez; Virginie Paris; Maxime Laroche; Saoussen Oueslati; Laurent Dortet; Stéphanie Simon; Thierry Naas
Journal:  Antimicrob Agents Chemother       Date:  2019-12-20       Impact factor: 5.191

Review 2.  The Global Ascendency of OXA-48-Type Carbapenemases.

Authors:  Johann D D Pitout; Gisele Peirano; Marleen M Kock; Kathy-Anne Strydom; Yasufumi Matsumura
Journal:  Clin Microbiol Rev       Date:  2019-11-13       Impact factor: 26.132

3.  False-Positive Carbapenem-Hydrolyzing Confirmatory Tests Due to ACT-28, a Chromosomally Encoded AmpC with Weak Carbapenemase Activity from Enterobacter kobei.

Authors:  Agnès B Jousset; Saoussen Oueslati; Sandrine Bernabeu; Julie Takissian; Elodie Creton; Anaïs Vogel; Aimie Sauvadet; Garance Cotellon; Lauraine Gauthier; Rémy A Bonnin; Laurent Dortet; Thierry Naas
Journal:  Antimicrob Agents Chemother       Date:  2019-04-25       Impact factor: 5.191

4.  Genetic and Biochemical Characterization of OXA-535, a Distantly Related OXA-48-Like β-Lactamase.

Authors:  L Dabos; A B Jousset; R A Bonnin; N Fortineau; A Zavala; P Retailleau; B I Iorga; T Naas
Journal:  Antimicrob Agents Chemother       Date:  2018-09-24       Impact factor: 5.191

5.  Structural Analysis of The OXA-48 Carbapenemase Bound to A "Poor" Carbapenem Substrate, Doripenem.

Authors:  Krisztina M Papp-Wallace; Vijay Kumar; Elise T Zeiser; Scott A Becka; Focco van den Akker
Journal:  Antibiotics (Basel)       Date:  2019-09-11

6.  Biochemical and Structural Characterization of OXA-405, an OXA-48 Variant with Extended-Spectrum β-Lactamase Activity.

Authors:  Saoussen Oueslati; Pascal Retailleau; Ludovic Marchini; Laurent Dortet; Rémy A Bonnin; Bogdan I Iorga; Thierry Naas
Journal:  Microorganisms       Date:  2019-12-21

7.  Evaluation of the Revogene Carba C Assay for Detection and Differentiation of Carbapenemase-Producing Gram-Negative Bacteria.

Authors:  Delphine Girlich; Marine Laguide; Laurent Dortet; Thierry Naas
Journal:  J Clin Microbiol       Date:  2020-03-25       Impact factor: 5.948

Review 8.  OXA-48 Carbapenemase-Producing Enterobacterales in Spanish Hospitals: An Updated Comprehensive Review on a Rising Antimicrobial Resistance.

Authors:  Mario Rivera-Izquierdo; Antonio Jesús Láinez-Ramos-Bossini; Carlos Rivera-Izquierdo; Jairo López-Gómez; Nicolás Francisco Fernández-Martínez; Pablo Redruello-Guerrero; Luis Miguel Martín-delosReyes; Virginia Martínez-Ruiz; Elena Moreno-Roldán; Eladio Jiménez-Mejías
Journal:  Antibiotics (Basel)       Date:  2021-01-18

Review 9.  Emerging Transcriptional and Genomic Mechanisms Mediating Carbapenem and Polymyxin Resistance in Enterobacteriaceae: a Systematic Review of Current Reports.

Authors:  Masego Mmatli; Nontombi Marylucy Mbelle; Nontuthuko E Maningi; John Osei Sekyere
Journal:  mSystems       Date:  2020-12-15       Impact factor: 6.496

10.  Analysis of β-lactone formation by clinically observed carbapenemases informs on a novel antibiotic resistance mechanism.

Authors:  Kristina M J Aertker; H T Henry Chan; Christopher T Lohans; Christopher J Schofield
Journal:  J Biol Chem       Date:  2020-09-22       Impact factor: 5.157
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