MiR-876-5p suppresses cell proliferation by targeting Angiopoietin-1 in the psoriasis.

Psoriasis is an autoimmune disease characterized by abnormal differentiation and hyper-proliferation of epidermal keratinocytes. The object of the study is to investigate the role of miRNA-876-5p in psoriasis. It reported that MicroRNAs (miRNAs) played roles in the malignant progression in psoriasis development. The expression of miR-876-5p was found to be down-regulated in psoriasic tissue and blood of patients. The luciferase assay verified the targeting role of miR-876-5p to 3'UTR of Angiopoietin-1 (Ang-1). Proliferation of psoriasic cells were inhibited by miR-876-5p and hold on G0/G1 phase. Further studies showed that miR-876-5p suppressed proliferation by restraining the expression of Ang-1, which would regulate the phosphorylation level of PI3K, AKT, mTOR and ERK in psoriasic cells. Invasion and adhesion, serving as important behavioral traits of epidermal keratinocytes cells, were suppressed by excessive miR-876-5p in psoriasic cells also. MiR-876-5p would be expected to be biomarker and potential therapeutic targets for the treatment of psoriasis.