OBJECTIVE: Lung cancer is classified as a single entity comprised of multiple histological subtypes. But how similar are these subtypes on a genetic level? This paper aims to address this question through a concise overview of germline and somatic differences between small cell lung cancer, lung adenocarcinoma, and lung squamous cell carcinoma. METHODS: We reveal the weak overlap found between these 3 lung cancer subtypes using published data from one of the largest germline genetic studies on lung cancer to date and somatic mutation data from Catalogue of Somatic Mutations in Cancer (COSMIC). RESULTS: These data indicate that these 3 subtypes share very little with each other at the genetic level. At the germline SNP level, only 24 independent SNPs from 2 chromosomes were shared across all 3 subtypes. We also demonstrate that only 30 unique cancer-specific mutations overlap the 3 subtypes from COSMIC, and that this is fewer than overlapping mutations chosen at random. Finally, we show that only 3 somatic mutational signatures are shared between these 3 subtypes. CONCLUSION: This paper highlights that these 3 lung cancer subtypes may be distinct diseases at the genetic level. In the era of precision medicine, we feel that these genomic differences will be of utmost importance in the choice of lung cancer therapy in the future.
OBJECTIVE:Lung cancer is classified as a single entity comprised of multiple histological subtypes. But how similar are these subtypes on a genetic level? This paper aims to address this question through a concise overview of germline and somatic differences between small cell lung cancer, lung adenocarcinoma, and lung squamous cell carcinoma. METHODS: We reveal the weak overlap found between these 3 lung cancer subtypes using published data from one of the largest germline genetic studies on lung cancer to date and somatic mutation data from Catalogue of Somatic Mutations in Cancer (COSMIC). RESULTS: These data indicate that these 3 subtypes share very little with each other at the genetic level. At the germline SNP level, only 24 independent SNPs from 2 chromosomes were shared across all 3 subtypes. We also demonstrate that only 30 unique cancer-specific mutations overlap the 3 subtypes from COSMIC, and that this is fewer than overlapping mutations chosen at random. Finally, we show that only 3 somatic mutational signatures are shared between these 3 subtypes. CONCLUSION: This paper highlights that these 3 lung cancer subtypes may be distinct diseases at the genetic level. In the era of precision medicine, we feel that these genomic differences will be of utmost importance in the choice of lung cancer therapy in the future.
Authors: Krista A Zanetti; Zhaoming Wang; Melinda Aldrich; Christopher I Amos; William J Blot; Elise D Bowman; Laurie Burdette; Qiuyin Cai; Neil Caporaso; Charles C Chung; Elizabeth M Gillanders; Christopher A Haiman; Helen M Hansen; Brian E Henderson; Laurence N Kolonel; Loic Le Marchand; Shengchao Li; Lorna Haughton McNeill; Bríd M Ryan; Ann G Schwartz; Jennette D Sison; Margaret R Spitz; Margaret Tucker; Angela S Wenzlaff; John K Wiencke; Lynne Wilkens; Margaret R Wrensch; Xifeng Wu; Wei Zheng; Weiyin Zhou; David Christiani; Julie R Palmer; Trevor M Penning; Alyssa G Rieber; Lynn Rosenberg; Edward A Ruiz-Narvaez; Li Su; Anil Vachani; Yongyue Wei; Alexander S Whitehead; Stephen J Chanock; Curtis C Harris Journal: Lung Cancer Date: 2016-05-13 Impact factor: 5.705
Authors: Katherine A Hoadley; Christina Yau; Denise M Wolf; Andrew D Cherniack; David Tamborero; Sam Ng; Max D M Leiserson; Beifang Niu; Michael D McLellan; Vladislav Uzunangelov; Jiashan Zhang; Cyriac Kandoth; Rehan Akbani; Hui Shen; Larsson Omberg; Andy Chu; Adam A Margolin; Laura J Van't Veer; Nuria Lopez-Bigas; Peter W Laird; Benjamin J Raphael; Li Ding; A Gordon Robertson; Lauren A Byers; Gordon B Mills; John N Weinstein; Carter Van Waes; Zhong Chen; Eric A Collisson; Christopher C Benz; Charles M Perou; Joshua M Stuart Journal: Cell Date: 2014-08-07 Impact factor: 41.582
Authors: Maria N Timofeeva; Rayjean J Hung; Thorunn Rafnar; David C Christiani; John K Field; Heike Bickeböller; Angela Risch; James D McKay; Yufei Wang; Juncheng Dai; Valerie Gaborieau; John McLaughlin; Darren Brenner; Steven A Narod; Neil E Caporaso; Demetrius Albanes; Michael Thun; Timothy Eisen; H-Erich Wichmann; Albert Rosenberger; Younghun Han; Wei Chen; Dakai Zhu; Margaret Spitz; Xifeng Wu; Mala Pande; Yang Zhao; David Zaridze; Neonilia Szeszenia-Dabrowska; Jolanta Lissowska; Peter Rudnai; Eleonora Fabianova; Dana Mates; Vladimir Bencko; Lenka Foretova; Vladimir Janout; Hans E Krokan; Maiken Elvestad Gabrielsen; Frank Skorpen; Lars Vatten; Inger Njølstad; Chu Chen; Gary Goodman; Mark Lathrop; Simone Benhamou; Tõnu Vooder; Kristjan Välk; Mari Nelis; Andres Metspalu; Olaide Raji; Ying Chen; John Gosney; Triantafillos Liloglou; Thomas Muley; Hendrik Dienemann; Gudmar Thorleifsson; Hongbing Shen; Kari Stefansson; Paul Brennan; Christopher I Amos; Richard Houlston; Maria Teresa Landi Journal: Hum Mol Genet Date: 2012-08-16 Impact factor: 6.150
Authors: Simon A Forbes; David Beare; Prasad Gunasekaran; Kenric Leung; Nidhi Bindal; Harry Boutselakis; Minjie Ding; Sally Bamford; Charlotte Cole; Sari Ward; Chai Yin Kok; Mingming Jia; Tisham De; Jon W Teague; Michael R Stratton; Ultan McDermott; Peter J Campbell Journal: Nucleic Acids Res Date: 2014-10-29 Impact factor: 16.971
Authors: Joshua D Campbell; Anton Alexandrov; Jaegil Kim; Jeremiah Wala; Alice H Berger; Chandra Sekhar Pedamallu; Sachet A Shukla; Guangwu Guo; Angela N Brooks; Bradley A Murray; Marcin Imielinski; Xin Hu; Shiyun Ling; Rehan Akbani; Mara Rosenberg; Carrie Cibulskis; Aruna Ramachandran; Eric A Collisson; David J Kwiatkowski; Michael S Lawrence; John N Weinstein; Roel G W Verhaak; Catherine J Wu; Peter S Hammerman; Andrew D Cherniack; Gad Getz; Maxim N Artyomov; Robert Schreiber; Ramaswamy Govindan; Matthew Meyerson Journal: Nat Genet Date: 2016-05-09 Impact factor: 38.330