Literature DB >> 2986287

Individual tumors of multifocal EB virus-induced malignant lymphomas in tamarins arise from different B-cell clones.

M L Cleary, M A Epstein, S Finerty, R F Dorfman, G W Bornkamm, J K Kirkwood, A J Morgan, J Sklar.   

Abstract

Cotton-top tamarins were inoculated with sufficient Epstein-Barr virus to induce multiple tumors in each animal within 14 to 21 days. The tumors consisted of large-cell lymphomas that contained multiple copies of the Epstein-Barr virus genome and generated Epstein-Barr virus-carrying cell lines showing no detectable consistent chromosomal abnormality. Hybridization of tumor DNA with immunoglobulin gene probes revealed that each lymphoma was oligo- or monoclonal in origin and that individual tumors from the same animal arose from different B-cell clones. Thus the virus induced multiple transformation events in tamarins in vivo to cause malignant tumors resembling the Epstein-Barr virus-associated lymphomas of patients with organ transplants.

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Year:  1985        PMID： 2986287     DOI： 10.1126/science.2986287

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  23 in total

1.  Primary immune responses by cord blood CD4(+) T cells and NK cells inhibit Epstein-Barr virus B-cell transformation in vitro.

Authors:  A Douglas Wilson; Andrew J Morgan
Journal:  J Virol       Date:  2002-05       Impact factor: 5.103

Review 2.  The expression and function of Epstein-Barr virus encoded latent genes.

Authors:  L S Young; C W Dawson; A G Eliopoulos
Journal:  Mol Pathol       Date:  2000-10

3.  Mapping of B-cell epitopes on the polypeptide chain of the Epstein-Barr virus major envelope glycoprotein and candidate vaccine molecule gp340.

Authors:  R J Pither; C X Zhang; C Shiels; J Tarlton; S Finerty; A J Morgan
Journal:  J Virol       Date:  1992-02       Impact factor: 5.103

4.  Epstein-Barr and human immunodeficiency viruses in acquired immunodeficiency syndrome-related primary central nervous system lymphoma.

Authors:  S Morgello
Journal:  Am J Pathol       Date:  1992-08       Impact factor: 4.307

Review 5.  Control of viral disease: the development of Epstein-Barr virus vaccines.

Authors:  A J Morgan
Journal:  Springer Semin Immunopathol       Date:  1991

6.  The mother lode of liver transplantation, with particular reference to our new journal.

Authors:  T E Starzl
Journal:  Liver Transpl Surg       Date:  1998-01

7.  Demonstration in vitro of cell mediated immunity to Epstein-Barr virus in cotton-top tamarins.

Authors:  S Finerty; F T Scullion; A J Morgan
Journal:  Clin Exp Immunol       Date:  1988-08       Impact factor: 4.330

8.  Not all potently neutralizing, vaccine-induced antibodies to Epstein-Barr virus ensure protection of susceptible experimental animals.

Authors:  M A Epstein; B J Randle; S Finerty; J K Kirkwood
Journal:  Clin Exp Immunol       Date:  1986-03       Impact factor: 4.330

9.  Association of Hodgkin's lymphoma with Epstein Barr virus infection.

Authors:  Elmir Cickusić; Jasminka Mustedanagić-Mujanović; Ermina Iljazović; Zinaida Karasalihović; Ina Skaljić
Journal:  Bosn J Basic Med Sci       Date:  2007-02       Impact factor: 3.363

10.  Latent Epstein-Barr virus infection in cottontop tamarins. A possible model for Epstein-Barr virus infection in humans.

Authors:  G Niedobitek; A Agathanggelou; S Finerty; R Tierney; P Watkins; E L Jones; A Morgan; L S Young; N Rooney
Journal:  Am J Pathol       Date:  1994-10       Impact factor: 4.307
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