| Literature DB >> 29858816 |
Jürgen Sauter1, Christian Schäfer2, Alexander H Schmidt2.
Abstract
HLA haplotype frequencies are of use in a variety of settings. Such data is typically derived either from family pedigree data by targeted typing or statistical analysis of large population-specific genotype samples. As established tools for the latter approach lacked ability to treat the amount, ambiguity, and inhomogeneity found in genotype data in hematopoietic stem cell donor registries, we developed Hapl-o-Mat to alleviate these specific shortcomings.Entities:
Keywords: Bioinformatics; Expectation-maximization algorithm; HLA; Haplotype; Immunogenetics; Open-source software; Population genetics
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Year: 2018 PMID： 29858816 DOI： 10.1007/978-1-4939-8546-3_19
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745