Emmely W de Roos1, Lies Lahousse2, Katia M C Verhamme3, Gert-Jan Braunstahl4, M Arfan Ikram5, Johannes C C M In 't Veen4, Bruno H Ch Stricker6, Guy G O Brusselle7. 1. Department of Respiratory Medicine, Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium; Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands. 2. Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands; Department of Bioanalysis, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. 3. Department of Bioanalysis, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium; Department of Medical Informatics, Erasmus MC - University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands. 4. Department of Respiratory Medicine Franciscus Gasthuis & Vlietland, PO Box 10900, 3045 PM Rotterdam, The Netherlands. 5. Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands. 6. Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus MC - University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands. 7. Department of Respiratory Medicine, Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium; Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands; Department of Respiratory Medicine Erasmus MC - University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands. Electronic address: guy.brusselle@ugent.be.
Abstract
BACKGROUND: Little is known on the prevalence and characteristics of asthma in middle-aged and older adults, since previous studies mainly focused on children and young adults. Therefore, the aim was to investigate the prevalence of physician-diagnosed asthma and its comorbidities, in a population-based cohort of adults 45 years of age and over. METHODS: We identified participants with physician-diagnosed asthma in the Rotterdam Study; a prospective population-based cohort in the Netherlands. Pulmonary function measurements and comorbidities of the asthma cases were assessed at baseline and compared to those of the general population. RESULTS: Out of 14,621 participants (mean age 65.5 years; 59% women), 524 subjects (31.5%males) had physician-diagnosed asthma at study entry, implicating an asthma prevalence of 3.6% [95% Confidence Interval (CI) 3.3%-3.9%] (2.8% in males and 4.2% in females). Asthmatic subjects had a significantly higher prevalence of obesity and depressive symptoms (Odds Ratio [OR]: 2,02 [95% CI 1,66-2,47] and [OR]: 2,01 [95% CI 1,52-2,66] respectively). Longer duration of asthma and current smoking were associated with lower lung function in asthmatic subjects. CONCLUSION: Four percent of middle-aged and older adults have physician-diagnosed asthma. These adult asthmatics suffer more frequently from obesity and depression than subjects without obstructive lung disease.
BACKGROUND: Little is known on the prevalence and characteristics of asthma in middle-aged and older adults, since previous studies mainly focused on children and young adults. Therefore, the aim was to investigate the prevalence of physician-diagnosed asthma and its comorbidities, in a population-based cohort of adults 45 years of age and over. METHODS: We identified participants with physician-diagnosed asthma in the Rotterdam Study; a prospective population-based cohort in the Netherlands. Pulmonary function measurements and comorbidities of the asthma cases were assessed at baseline and compared to those of the general population. RESULTS: Out of 14,621 participants (mean age 65.5 years; 59% women), 524 subjects (31.5%males) had physician-diagnosed asthma at study entry, implicating an asthma prevalence of 3.6% [95% Confidence Interval (CI) 3.3%-3.9%] (2.8% in males and 4.2% in females). Asthmatic subjects had a significantly higher prevalence of obesity and depressive symptoms (Odds Ratio [OR]: 2,02 [95% CI 1,66-2,47] and [OR]: 2,01 [95% CI 1,52-2,66] respectively). Longer duration of asthma and current smoking were associated with lower lung function in asthmatic subjects. CONCLUSION: Four percent of middle-aged and older adults have physician-diagnosed asthma. These adult asthmatics suffer more frequently from obesity and depression than subjects without obstructive lung disease.
Authors: Ida Mogensen; Judith M Vonk; Sara R A Wijnant; Xingwu Zhou; H Marike Boezen; Guy Brusselle; Lies Lahousse; Christer Janson; Andrei Malinovschi Journal: ERJ Open Res Date: 2020-10-05
Authors: Silvan Licher; Alis Heshmatollah; Kimberly D van der Willik; Bruno H Ch Stricker; Rikje Ruiter; Emmely W de Roos; Lies Lahousse; Peter J Koudstaal; Albert Hofman; Lana Fani; Guy G O Brusselle; Daniel Bos; Banafsheh Arshi; Maryam Kavousi; Maarten J G Leening; M Kamran Ikram; M Arfan Ikram Journal: PLoS Med Date: 2019-02-04 Impact factor: 11.069
Authors: M Arfan Ikram; Guy Brusselle; Mohsen Ghanbari; André Goedegebure; M Kamran Ikram; Maryam Kavousi; Brenda C T Kieboom; Caroline C W Klaver; Robert J de Knegt; Annemarie I Luik; Tamar E C Nijsten; Robin P Peeters; Frank J A van Rooij; Bruno H Stricker; André G Uitterlinden; Meike W Vernooij; Trudy Voortman Journal: Eur J Epidemiol Date: 2020-05-04 Impact factor: 8.082
Authors: Elizabeth Benz; Katerina Trajanoska; Josje D Schoufour; Lies Lahousse; Emmely W de Roos; Natalie Terzikhan; Carolina Medina-Gomez; Katia Verhamme; Ross Williams; Bruno H Stricker; Oscar H Franco; M Arfan Ikram; Fernando Rivadeneira; Guy Brusselle Journal: ERJ Open Res Date: 2021-03-08
Authors: Elizabeth Benz; Sara R A Wijnant; Katerina Trajanoska; Johnmary T Arinze; Emmely W de Roos; Maria de Ridder; Ross Williams; Frank van Rooij; Katia M C Verhamme; M Arfan Ikram; Bruno H Stricker; Fernando Rivadeneira; Lies Lahousse; Guy G Brusselle Journal: ERJ Open Res Date: 2022-01-10
Authors: Premysl Velek; Annemarie I Luik; Guy G O Brusselle; Bruno Ch Stricker; Patrick J E Bindels; Maryam Kavousi; Brenda C T Kieboom; Trudy Voortman; Rikje Ruiter; M Arfan Ikram; M Kamran Ikram; Evelien I T de Schepper; Silvan Licher Journal: BMC Med Date: 2022-09-08 Impact factor: 11.150
Authors: Emmely W de Roos; Lies Lahousse; Katia M C Verhamme; Gert-Jan Braunstahl; Johannes J C C M In 't Veen; Bruno H Stricker; Guy G O Brusselle Journal: ERJ Open Res Date: 2021-07-12
Authors: Kimberly D van der Willik; Liliana P Rojas-Saunero; Jeremy A Labrecque; M Arfan Ikram; Sanne B Schagen; Bruno H Stricker; Rikje Ruiter Journal: Eur J Epidemiol Date: 2019-12-20 Impact factor: 8.082
Authors: Johnmary T Arinze; Emmely W de Roos; Leila Karimi; Katia M C Verhamme; Bruno H Stricker; Guy G Brusselle Journal: ERJ Open Res Date: 2020-04-19