Giuseppe Lanza1, Stella Silvia Centonze2, Gera Destro3, Veronica Vella4, Maria Bellomo2, Manuela Pennisi5, Rita Bella6, Domenico Ciavardelli7. 1. Oasi Research Institute - IRCCS, Troina, Italy. Electronic address: glanza@oasi.en.it. 2. School of Human and Social Science, University "Kore" of Enna, Enna, Italy. 3. Centro diurno Alzheimer, Ospedale "Michele Chiello", ASP 4, Piazza Armerina, Italy. 4. School of Human and Social Science, University "Kore" of Enna, Enna, Italy; Department of Clinical and Molecular Bio-Medicine, Endocrinology Unit, University of Catania "Garibaldi-Nesima Medical Center", Catania, Italy. 5. Spinal Unit, Emergency Hospital "Cannizzaro", Catania, Italy. 6. Department of Medical and Surgical Sciences and Advanced Technologies, Section of Neurosciences, Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele, Catania, Italy. 7. School of Human and Social Science, University "Kore" of Enna, Enna, Italy; Centro Scienze dell'Invecchiamento e Medicina Traslazionale - CeSI-Met, Chieti, Italy.
Abstract
OBJECTIVES: Among the complementary and alternative medicine, Shiatsu might represent a feasible option for depression in Alzheimer's disease (AD). We evaluated Shiatsu on mood, cognition, and functional independence in patients undergoing physical activity. DESIGN: Single-blind randomized controlled study. SETTING: Dedicated Community Center for patients with AD. INTERVENTIONS:AD patients with depression were randomly assigned to the "active group" (Shiatsu + physical activity) or the "control group" (physical activity alone). Shiatsu was performed by the same therapist once a week for ten months. MAIN OUTCOME MEASURES: Global cognitive functioning (Mini Mental State Examination - MMSE), depressive symptoms (Geriatric Depression Scale - GDS), and functional status (Activity of Daily Living - ADL, Instrumental ADL - IADL) were assessed before and after the intervention. RESULTS: We found a within-group improvement of MMSE, ADL, and GDS in the active group. However, the analysis of differences before and after the interventions showed a statistically significant decrease of GDS score only in the active group. CONCLUSIONS: The combination of Shiatsu and physical activity improved depression in AD patients compared to physical activity alone. The pathomechanism might involve neuroendocrine-mediated effects of Shiatsu on neural circuits implicated in mood and affect regulation.
RCT Entities:
OBJECTIVES: Among the complementary and alternative medicine, Shiatsu might represent a feasible option for depression in Alzheimer's disease (AD). We evaluated Shiatsu on mood, cognition, and functional independence in patients undergoing physical activity. DESIGN: Single-blind randomized controlled study. SETTING: Dedicated Community Center for patients with AD. INTERVENTIONS:ADpatients with depression were randomly assigned to the "active group" (Shiatsu + physical activity) or the "control group" (physical activity alone). Shiatsu was performed by the same therapist once a week for ten months. MAIN OUTCOME MEASURES: Global cognitive functioning (Mini Mental State Examination - MMSE), depressive symptoms (Geriatric Depression Scale - GDS), and functional status (Activity of Daily Living - ADL, Instrumental ADL - IADL) were assessed before and after the intervention. RESULTS: We found a within-group improvement of MMSE, ADL, and GDS in the active group. However, the analysis of differences before and after the interventions showed a statistically significant decrease of GDS score only in the active group. CONCLUSIONS: The combination of Shiatsu and physical activity improved depression in ADpatients compared to physical activity alone. The pathomechanism might involve neuroendocrine-mediated effects of Shiatsu on neural circuits implicated in mood and affect regulation.
Authors: Jennifer A Watt; Zahra Goodarzi; Areti Angeliki Veroniki; Vera Nincic; Paul A Khan; Marco Ghassemi; Yonda Lai; Victoria Treister; Yuan Thompson; Raphael Schneider; Andrea C Tricco; Sharon E Straus Journal: BMJ Date: 2021-03-24
Authors: Giusy Rita Maria La Rosa; Giuseppe Gattuso; Eugenio Pedullà; Ernesto Rapisarda; Daria Nicolosi; Mario Salmeri Journal: Oncol Lett Date: 2020-03-03 Impact factor: 2.967