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Literature DB >> 29856952

Tubulin Posttranslational Modifications and Emerging Links to Human Disease.

Maria M Magiera¹, Puja Singh², Sudarshan Gadadhar², Carsten Janke³.

Abstract

Tubulin posttranslational modifications are currently emerging as important regulators of the microtubule cytoskeleton and thus have a strong potential to be implicated in a number of disorders. Here, we review the latest advances in understanding the physiological roles of tubulin modifications and their links to a variety of pathologies.

Entities: Species

Mesh：

Substances：
Tubulin

Year: 2018 PMID： 29856952 DOI： 10.1016/j.cell.2018.05.018

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

49 in total

Review 1. Cardiac microtubules in health and heart disease.

Authors: Matthew A Caporizzo; Christina Yingxian Chen; Benjamin L Prosser
Journal: Exp Biol Med (Maywood) Date: 2019-08-09

2. Polyglutamylation of tubulin's C-terminal tail controls pausing and motility of kinesin-3 family member KIF1A.

Authors: Dominique V Lessard; Oraya J Zinder; Takashi Hotta; Kristen J Verhey; Ryoma Ohi; Christopher L Berger
Journal: J Biol Chem Date: 2019-02-15 Impact factor: 5.157

3. DYRK1B regulates Hedgehog-induced microtubule acetylation.

Authors: Rajeev Singh; Philipp Simon Holz; Katrin Roth; Anna Hupfer; Wolfgang Meissner; Rolf Müller; Malte Buchholz; Thomas M Gress; Hans-Peter Elsässer; Ralf Jacob; Matthias Lauth
Journal: Cell Mol Life Sci Date: 2018-10-13 Impact factor: 9.261

4. More is not always better: hyperglutamylation leads to neurodegeneration.

Authors: Anna Akhmanova; Casper C Hoogenraad
Journal: EMBO J Date: 2018-11-23 Impact factor: 11.598

5. Asymmetries in the cilia of Chlamydomonas.

Authors: Susan K Dutcher
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2019-12-30 Impact factor: 6.237

6. Non-enzymatic Activity of the α-Tubulin Acetyltransferase αTAT Limits Synaptic Bouton Growth in Neurons.

Authors: Courtney E Coombes; Harriet A J Saunders; Anirudh G Mannava; Dena M Johnson-Schlitz; Taylor A Reid; Sneha Parmar; Mark McClellan; Connie Yan; Stephen L Rogers; Jay Z Parrish; Michael Wagenbach; Linda Wordeman; Jill Wildonger; Melissa K Gardner
Journal: Curr Biol Date: 2020-01-09 Impact factor: 10.834

Tubulin Posttranslational Modifications and Emerging Links to Human Disease.

Review 1. Cardiac microtubules in health and heart disease.

2. Polyglutamylation of tubulin's C-terminal tail controls pausing and motility of kinesin-3 family member KIF1A.

3. DYRK1B regulates Hedgehog-induced microtubule acetylation.

4. More is not always better: hyperglutamylation leads to neurodegeneration.

5. Asymmetries in the cilia of Chlamydomonas.

6. Non-enzymatic Activity of the α-Tubulin Acetyltransferase αTAT Limits Synaptic Bouton Growth in Neurons.

Review 7. Spatial control of membrane traffic in neuronal dendrites.

8. C-Terminal Tail Polyglycylation and Polyglutamylation Alter Microtubule Mechanical Properties.

9. Genetically encoded live-cell sensor for tyrosinated microtubules.

Review 10. Remodeling the epigenome and (epi)cytoskeleton: a new paradigm for co-regulation by methylation.