Literature DB >> 2985052

The specificity of yeast low-Km cyclic AMP phosphodiesterase towards free bivalent metal ions and the diastereoisomers of cyclic adenosine phosphorothioate.

K Suoranta, J Londesborough.   

Abstract

The relative activity of a zinc-containing cyclic AMP phosphodiesterase towards the (Sp)- compared with the (Rp)-diastereoisomer of cyclic adensine phosphorothioate varied with the identity of the free bivalent metal ion from more than 35 to 0.074 along the series Mg2+ greater than Mn2+ greater than Co2+ greater than Zn2+ greater than Cd2+, showing that this ion, and not the tightly bound zinc, bonds to the phosphorothioate moiety of the substrate.

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Year:  1985        PMID： 2985052      PMCID： PMC1144795          DOI： 10.1042/bj2260897

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  14 in total

1.  Quantitative estimation of 3'5' cyclic AMP phosphodiesterase using anion exchange resin in a batch process.

Authors:  J Londesborough
Journal:  Anal Biochem       Date:  1976-04       Impact factor: 3.365

2.  Estimation of the dissociation constants of enzyme-substrate complexes from steady-state measurements. Interpretation of pH-independence of Km.

Authors:  A Cornish-Bowden
Journal:  Biochem J       Date:  1976-02-01       Impact factor: 3.857

3.  Adenosine 3',5'-cyclic phosphorothioate: synthesis and biological properties.

Authors:  F Eckstein; L P Simonson; H P Bär
Journal:  Biochemistry       Date:  1974-08-27       Impact factor: 3.162

4.  Multiple cyclic nucleotide phosphodiesterase activities from rat brain.

Authors:  W J Thompson; M M Appleman
Journal:  Biochemistry       Date:  1971-01-19       Impact factor: 3.162

5.  The direct linear plot. A new graphical procedure for estimating enzyme kinetic parameters.

Authors:  R Eisenthal; A Cornish-Bowden
Journal:  Biochem J       Date:  1974-06       Impact factor: 3.857

6.  The stability constants of some metal ion complexes of 3',5'-cyclic AMP.

Authors:  J Londesborough; T M Lukkari
Journal:  J Cyclic Nucleotide Res       Date:  1979

7.  The zinc-containing high Km cyclic nucleotide phosphodiesterase of bakers' yeast.

Authors:  J Londesborough; K Suoranta
Journal:  J Biol Chem       Date:  1983-03-10       Impact factor: 5.157

8.  A stereochemical investigation of the hydrolysis of cyclic AMP and the (Sp)-and (Rp)-diastereoisomers of adenosine cyclic 3':5'-phosphorothioate by bovine heart and baker's-yeast cyclic AMP phosphodiesterases.

Authors:  R L Jarvest; G Lowe; J Baraniak; W J Stec
Journal:  Biochem J       Date:  1982-05-01       Impact factor: 3.857

9.  Diastereomers of the nucleoside phosphorothioates as probes of the structure of the metal nucleotide substrates and of the nucleotide binding site of yeast hexokinase.

Authors:  E K Jaffe; M Cohn
Journal:  J Biol Chem       Date:  1979-11-10       Impact factor: 5.157

10.  Properties of the activator-dependent cyclic nucleotide phosphodiesterase from bovine heart.

Authors:  T E Donnelly
Journal:  Biochim Biophys Acta       Date:  1977-01-11
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  2 in total

1.  Crystal Structures of Candida albicans Phosphodiesterase 2 and Implications for Its Biological Functions.

Authors:  Ting Yao; Yiyou Huang; Meng Zhang; Yujuan Chen; Hairun Pei; Jianyou Shi; Huanchen Wang; Yousheng Wang; Hengming Ke
Journal:  Biochemistry       Date:  2018-10-04       Impact factor: 3.321

2.  Dual specificity and novel structural folding of yeast phosphodiesterase-1 for hydrolysis of second messengers cyclic adenosine and guanosine 3',5'-monophosphate.

Authors:  Yuanyuan Tian; Wenjun Cui; Manna Huang; Howard Robinson; Yiqian Wan; Yousheng Wang; Hengming Ke
Journal:  Biochemistry       Date:  2014-07-22       Impact factor: 3.162
  2 in total

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