Gregers Stig Andersen1, Rasmus Wibaek1,2, Pernille Kaestel2, Tsinuel Girma3, Bitiya Admassu2,4, Mubarek Abera2,5, Dorte Vistisen1, Marit Eika Jørgensen1, Kim F Michaelsen2, Henrik Friis2, Jonathan C K Wells6. 1. Steno Diabetes Center Copenhagen, Gentofte, Denmark. 2. Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark. 3. Department of Pediatrics and Child Health, Jimma University Specialized Hospital, Jimma, Ethiopia. 4. Department of Population and Family Health, Faculty of Public Health, Jimma University, Jimma, Ethiopia. 5. Department of Psychiatry, Faculty of Medical Sciences, Jimma University, Jimma, Ethiopia. 6. Childhood Nutrition Research Centre, University College London Great Ormond Street Institute of Child Health, London, UK.
Abstract
OBJECTIVE: The objective of this study was to identify subgroups with distinct fat and fat-free growth patterns in the first 6 months of life and describe predictors of these different patterns. METHODS: A total of 510 apparently healthy Ethiopian infants were followed from birth to 6 months of age. Each infant had at least three and up to six repeated measurements of fat and fat-free mass using air-displacement plethysmography. Latent class trajectory analyses were used to categorize infants in groups with distinct body composition patterns. RESULTS: Four distinct fat mass and two fat-free mass growth patterns were identified. Of the infants measured, 5% presented a delayed fat growth pattern and 3% presented a catch-up fat growth pattern involving low birth weight but a significant fat growth velocity from 2.5 to 6 months. A large class had a high fat level at birth and an accelerated fat growth pattern in early infancy. Fat-free growth was represented by two distinct classes with less variability. Catch-up growth was primarily seen in fat mass. CONCLUSIONS: We identified distinct patterns of delayed, catch-up, and accelerated fat growth in early infancy. This variability is not detected in regular anthropometric assessment and could be a mechanism linking early growth with later obesity and cardiometabolic risk.
OBJECTIVE: The objective of this study was to identify subgroups with distinct fat and fat-free growth patterns in the first 6 months of life and describe predictors of these different patterns. METHODS: A total of 510 apparently healthy Ethiopian infants were followed from birth to 6 months of age. Each infant had at least three and up to six repeated measurements of fat and fat-free mass using air-displacement plethysmography. Latent class trajectory analyses were used to categorize infants in groups with distinct body composition patterns. RESULTS: Four distinct fat mass and two fat-free mass growth patterns were identified. Of the infants measured, 5% presented a delayed fat growth pattern and 3% presented a catch-up fat growth pattern involving low birth weight but a significant fat growth velocity from 2.5 to 6 months. A large class had a high fat level at birth and an accelerated fat growth pattern in early infancy. Fat-free growth was represented by two distinct classes with less variability. Catch-up growth was primarily seen in fat mass. CONCLUSIONS: We identified distinct patterns of delayed, catch-up, and accelerated fat growth in early infancy. This variability is not detected in regular anthropometric assessment and could be a mechanism linking early growth with later obesity and cardiometabolic risk.
Authors: Bitiya Admassu; Jonathan C K Wells; Tsinuel Girma; Tefera Belachew; Christian Ritz; Victor Owino; Mubarek Abera; Rasmus Wibaek; Kim F Michaelsen; Pernille Kæstel; Henrik Friis; Gregers S Andersen Journal: Nutr Diabetes Date: 2018-09-07 Impact factor: 5.097
Authors: Rasmus Wibaek; Dorte Vistisen; Tsinuel Girma; Bitiya Admassu; Mubarek Abera; Alemseged Abdissa; Marit E Jørgensen; Pernille Kæstel; Kim F Michaelsen; Henrik Friis; Jonathan C K Wells; Gregers S Andersen Journal: PLoS Med Date: 2019-08-20 Impact factor: 11.069