Literature DB >> 29844925

Decompression for botulinum toxin-exacerbated cervical myeloradiculopathy in the setting of congenital stenosis and Arnold-Chiari I malformation.

Abhinav Mohan1, Eric Chang2.   

Abstract

INTRODUCTION: We present a case describing the management of a woman with severe, functionally limiting cervical myeloradiculopathy in the setting of congenital cervical canal stenosis and Arnold-Chiari I malformation. CASE
PRESENTATION: The subject is a 57-year-old woman with prior anterior cervical discectomy and fusion who presented with left-sided neck pain associated with radiculopathy, migraine, gait incoordination, and cervical dystonia. Cervical stenosis and Chiari malformation were confirmed using MRI. Conservative management with botulinum toxin, oral muscle relaxants, and cervical brace led to gradual exacerbation of symptoms. Due to failure of conservative management, surgical decompression with C3-C6 posterior laminoplasty was performed, resulting in complete resolution of all symptoms and markedly improved quality of life. DISCUSSION: This case reports a severe and nonspecific presentation of cervical myeloradiculopathy. Surgery for cervical myeloradiculopathy is controversial, and conservative therapy is initially preferred. However, in this case, conservative treatments likely led to paraspinal weakness, cervical hypermobility, and biomechanical instability, resulting in exacerbation of symptoms. Stretch/shear forces have been postulated to accelerate cervical myelopathy, and excessive cervical instability and range of motion are significant predictors of deterioration. In this case, surgical decompression with posterior cervical laminoplasty after 1 year of conservative management yielded significant pain relief and functional restoration, indicating the utility of this procedure even in the presence of Arnold-Chiari I malformation. This case illustrates that decompression can be effective for refractory cervical myeloradiculopathy associated with Chiari malformation, congenital stenosis, and prior anterior instrumentation, and highlights the potential risks of prolonged conservative management.

Entities:  

Year:  2018        PMID: 29844925      PMCID: PMC5962603          DOI: 10.1038/s41394-018-0077-4

Source DB:  PubMed          Journal:  Spinal Cord Ser Cases        ISSN: 2058-6124


  19 in total

1.  Surgical treatment of multilevel cervical spondylosis in patients with or without a history of syringomyelia.

Authors:  Jörg Klekamp
Journal:  Eur Spine J       Date:  2017-02-11       Impact factor: 3.134

2.  Selective laminectomy for cervical spondylotic myelopathy: a comparative analysis with laminoplasty technique.

Authors:  Han Chang; Choll Kim; Byung-Wan Choi
Journal:  Arch Orthop Trauma Surg       Date:  2017-03-13       Impact factor: 3.067

Review 3.  Epidemiology, diagnosis, and treatment of neck pain.

Authors:  Steven P Cohen
Journal:  Mayo Clin Proc       Date:  2015-02       Impact factor: 7.616

4.  Clinical evidence for cervical myelopathy due to Chiari malformation and spinal stenosis in a non-randomized group of patients with the diagnosis of fibromyalgia.

Authors:  Dan S Heffez; Ruth E Ross; Yvonne Shade-Zeldow; Konstantinos Kostas; Sagar Shah; Robert Gottschalk; Dean A Elias; Alan Shepard; Sue E Leurgans; Charity G Moore
Journal:  Eur Spine J       Date:  2004-04-09       Impact factor: 3.134

5.  A diagnostic dilemma: cervical myelopathy in the presence of chiari 1 malformation and multi-level cord compression in a 79-year-old woman.

Authors:  Marc Bullock; Anastasios Kanatas; Debashish Pal; Gerry Towns
Journal:  Br J Neurosurg       Date:  2007-04       Impact factor: 1.596

6.  Results of skip laminectomy-minimum 2-year follow-up study compared with open-door laminoplasty.

Authors:  Tateru Shiraishi; Kentaro Fukuda; Yoshiyuki Yato; Mitsukazu Nakamura; Takeshi Ikegami
Journal:  Spine (Phila Pa 1976)       Date:  2003-12-15       Impact factor: 3.468

Review 7.  Pathophysiology and natural history of cervical spondylotic myelopathy.

Authors:  Spyridon K Karadimas; W Mark Erwin; Claire G Ely; Joseph R Dettori; Michael G Fehlings
Journal:  Spine (Phila Pa 1976)       Date:  2013-10-15       Impact factor: 3.468

8.  Cervical spondylotic myelopathy: surgical results and factors affecting outcome with special reference to age differences.

Authors:  Tomosato Yamazaki; Kiyoyuki Yanaka; Hiroaki Sato; Kazuya Uemura; Atsuro Tsukada; Tadao Nose
Journal:  Neurosurgery       Date:  2003-01       Impact factor: 4.654

9.  Quality of life assessment with the medical outcomes study short form-36 among patients with cervical spondylotic myelopathy.

Authors:  Joseph T King; Kathleen A McGinnis; Mark S Roberts
Journal:  Neurosurgery       Date:  2003-01       Impact factor: 4.654

10.  Evaluation of conservative treatment and timing of surgical intervention for mild forms of cervical spondylotic myelopathy.

Authors:  Ling-DE Kong; Ling-Chen Meng; Lin-Feng Wang; Yong Shen; Pan Wang; Zi-Kun Shang
Journal:  Exp Ther Med       Date:  2013-07-16       Impact factor: 2.447

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  1 in total

1.  The Effect of Low Dose OnabotulinumtoxinA on Cervical Dystonia in Hypermobile Ehlers-Danlos Syndrome.

Authors:  Tina J Wang; Antonio Stecco; Khashayar Dashtipour
Journal:  Tremor Other Hyperkinet Mov (N Y)       Date:  2021-10-25
  1 in total

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