Literature DB >> 2983097

Nucleotide sequence of avian sarcoma virus UR2 and comparison of its transforming gene with other members of the tyrosine protein kinase oncogene family.

W S Neckameyer, L H Wang.   

Abstract

The genome of avian sarcoma virus UR2 was completely sequenced and found to have a size of 3,165 nucleotides. The UR2-specific transforming sequence, ros, with a length of 1,273 nucleotides, is inserted between the truncated gag gene coding for p19 and the env gene coding for gp37 of the UR2AV helper virus. The deduced amino acid sequence for the UR2 transforming protein P68 gives a molecular weight of 61,113 and shows that it is closely related to the oncogene family coding for tyrosine protein kinases. P68 contains two distinctive hydrophobic regions that are absent in other tyrosine kinases, and it has unique amino acid changes and insertions within the conserved domain of the kinases. These characteristics may modulate the activity and target specificity of P68.

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Year:  1985        PMID： 2983097      PMCID： PMC254722     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  31 in total

1.  Avian sarcoma virus UR2 encodes a transforming protein which is associated with a unique protein kinase activity.

Authors:  R A Feldman; L H Wang; H Hanafusa; P C Balduzzi
Journal:  J Virol       Date:  1982-04       Impact factor: 5.103

2.  Nucleotide sequence of Rous sarcoma virus.

Authors:  D E Schwartz; R Tizard; W Gilbert
Journal:  Cell       Date:  1983-03       Impact factor: 41.582

3.  A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments.

Authors:  J Messing; J Vieira
Journal:  Gene       Date:  1982-10       Impact factor: 3.688

4.  Corrections to the nucleotide sequence of the src gene of Rous sarcoma virus.

Authors:  A P Czernilofsky; A D Levinson; H E Varmus; J M Bishop; E Tischer; H Goodman
Journal:  Nature       Date:  1983-02-24       Impact factor: 49.962

5.  Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase.

Authors:  W C Barker; M O Dayhoff
Journal:  Proc Natl Acad Sci U S A       Date:  1982-05       Impact factor: 11.205

6.  The erbB gene of avian erythroblastosis virus is a member of the src gene family.

Authors:  T Yamamoto; T Nishida; N Miyajima; S Kawai; T Ooi; K Toyoshima
Journal:  Cell       Date:  1983-11       Impact factor: 41.582

7.  Nucleotide sequences from the adenovirus-2 genome.

Authors:  T R Gingeras; D Sciaky; R E Gelinas; J Bing-Dong; C E Yen; M M Kelly; P A Bullock; B L Parsons; K E O'Neill; R J Roberts
Journal:  J Biol Chem       Date:  1982-11-25       Impact factor: 5.157

8.  DNA sequence of the viral and cellular src gene of chickens. 1. Complete nucleotide sequence of an EcoRI fragment of recovered avian sarcoma virus which codes for gp37 and pp60src.

Authors:  T Takeya; R A Feldman; H Hanafusa
Journal:  J Virol       Date:  1982-10       Impact factor: 5.103

9.  Nucleotide sequence of Fujinami sarcoma virus: evolutionary relationship of its transforming gene with transforming genes of other sarcoma viruses.

Authors:  M Shibuya; H Hanafusa
Journal:  Cell       Date:  1982-10       Impact factor: 41.582

10.  Nucleotide sequence of Abelson murine leukemia virus genome: structural similarity of its transforming gene product to other onc gene products with tyrosine-specific kinase activity.

Authors:  E P Reddy; M J Smith; A Srinivasan
Journal:  Proc Natl Acad Sci U S A       Date:  1983-06       Impact factor: 11.205
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  55 in total

1.  Expression and rearrangement of the ROS1 gene in human glioblastoma cells.

Authors:  C Birchmeier; S Sharma; M Wigler
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

2.  Amino acids bracketing the predicted transmembrane domains of membrane proteins.

Authors:  C Pidgeon; R L Williard; S C Schroeder
Journal:  Pharm Res       Date:  1989-09       Impact factor: 4.200

3.  Phylogenetic and physical analysis of the 5' leader RNA sequences of avian retroviruses.

Authors:  P B Hackett; M W Dalton; D P Johnson; R B Petersen
Journal:  Nucleic Acids Res       Date:  1991-12-25       Impact factor: 16.971

4.  Two point mutations in the transmembrane domain of P68gag-ros inactive its transforming activity and cause a delay in membrane association.

Authors:  S M Jong; L H Wang
Journal:  J Virol       Date:  1991-01       Impact factor: 5.103

5.  Inhibition of the tyrosine kinase activity of v-src, v-fgr, and v-yes gene products by a monoclonal antibody which binds both amino and carboxy peptide fragments of pp60v-src.

Authors:  D J McCarley; J T Parsons; D C Benjamin; S J Parsons
Journal:  J Virol       Date:  1987-06       Impact factor: 5.103

6.  Characterization of cDNA clones for the human c-yes gene.

Authors:  J Sukegawa; K Semba; Y Yamanashi; M Nishizawa; N Miyajima; T Yamamoto; K Toyoshima
Journal:  Mol Cell Biol       Date:  1987-01       Impact factor: 4.272

7.  Fast co-evolution of sevenless and bride of sevenless in endopterygote insects.

Authors:  Riyue Bao; Markus Friedrich
Journal:  Dev Genes Evol       Date:  2008-04-08       Impact factor: 0.900

8.  Molecular basis of the activation of the tumorigenic potential of Gag-insulin receptor chimeras.

Authors:  B Poon; D Dixon; L Ellis; R A Roth; W J Rutter; L H Wang
Journal:  Proc Natl Acad Sci U S A       Date:  1991-02-01       Impact factor: 11.205

Review 9.  Insulin receptors: structure and function.

Authors:  E Van Obberghen; S Gammeltoft
Journal:  Experientia       Date:  1986-07-15

10.  The human c-ros gene (ROS) is located at chromosome region 6q16----6q22.

Authors:  L Nagarajan; E Louie; Y Tsujimoto; P C Balduzzi; K Huebner; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1986-09       Impact factor: 11.205
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