| Literature DB >> 2981150 |
G F Springer, C R Taylor, D R Howard, H Tegtmeyer, P R Desai, S M Murthy, B Felder, E F Scanlon.
Abstract
Tn antigen is the immediate precursor of the carcinoma (CA)-associated T antigen; both are masked in non-CA tissues. Tn antigen was detected by absorption of human anti-Tn antibody in 46 of 50 primary breast CAs and in all 6 metastases originating from Tn-positive primary CAs. Thirteen of 25 (52%) anaplastic CAs, but only 2 of 15 (13%) well differentiated CAs had more Tn than T; 1 anaplastic CA had neither antigen. Eighteen of 20 benign breast lesions had no Tn; the 2 positive lesions were premalignant. All 19 breast CAs, studied immunohistochemically, reacted strongly with human polyclonal anti-Tn; benign or normal glandular tissues had minimal or no reactivity. Among live cancer cell lines, the most malignant sublines had more Tn than T on their cell surfaces. Preliminary studies with rodent monoclonal anti-Tn and anti-T antibodies gave immunohistochemical reactivity patterns similar to those of the polyclonal antibodies, but the former were less sensitive in absorption tests. Tn is a CA marker that promises to be useful in tumor detection.Entities:
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Year: 1985 PMID： 2981150 DOI： 10.1002/1097-0142(19850201)55:3<561::aid-cncr2820550315>3.0.co;2-1
Source DB: PubMed Journal: Cancer ISSN： 0008-543X Impact factor: 6.860