Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Expression of a Tn-like epitope by carcinoma cells.

Literature DB >> 2449235

Expression of a Tn-like epitope by carcinoma cells.

D J Roxby¹, J M Skinner, A A Morley, S Weeks, M Burpee.

Abstract

A monoclonal antibody, FBT3, was raised against Tn positive erythrocytes and, using immunohistochemistry, fresh and fixed tissues from patients with cancer were studied to detect any expression of a Tn-like epitope. Expression was found in neoplastic cells, usually both in cytoplasm and on cell membranes, from 104 of 147 cases of carcinoma and 1 of 13 cases of lymphoma, but rarely in adjacent, morphologically normal cells. Tn expression was seen in some normal glandular cells but, unlike cancer cells, it was distributed as fine granules in a supranuclear position. Detection of a Tn-like epitope is of theoretical interest and may be of direct diagnostic value.

Entities: Disease Species

Mesh：

Substances：

Year: 1987 PMID： 2449235 PMCID： PMC2002405 DOI： 10.1038/bjc.1987.279

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

11 in total

1. The use of monoclonal antibodies to quantify the levels of sialoglycoproteins alpha and delta and variant sialoglycoproteins in human erythrocyte membranes.

Authors: A H Merry; C Hodson; E Thomson; G Mallinson; D J Anstee
Journal: Biochem J Date: 1986-01-01 Impact factor: 3.857

Review 2. Human carcinoma-associated precursor antigens of the blood group MN system and the host's immune responses to them.

Authors: G F Springer; P R Desai; M S Murthy; H Tegtmeyer; E F Scanlon
Journal: Prog Allergy Date: 1979

3. Seed agglutinin for rapid identification of Tn-polyagglutination.

Authors: G W Bird; J Wingham
Journal: Lancet Date: 1973-03-24 Impact factor: 79.321

4. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

Authors: S M Hsu; L Raine; H Fanger
Journal: J Histochem Cytochem Date: 1981-04 Impact factor: 2.479

9. Immunodot assay for determining the isotype and light chain type of murine monoclonal antibodies in unconcentrated hybridoma culture supernates.

Authors: J S McDougal; S W Browning; S Kennedy; D D Moore
Journal: J Immunol Methods Date: 1983-10-28 Impact factor: 2.303

10. Tn epitopes, immunoreactive with ordinary anti-Tn antibodies, on normal, desialylated human erythrocytes and on Thomsen-Friedenreich antigen isolated therefrom.

Authors: G F Springer; P R Desai
Journal: Mol Immunol Date: 1985-11 Impact factor: 4.407

1 in total

1. Semiquantitative immunohistochemical studies of blood group antigen A, B, H, Le(a), Le(b) structures and Ii backbone chains in the normal human cervix and in cervical adenocarcinoma.

Authors: N R Griffin; M Wells
Journal: Histochem J Date: 1993-03

1 in total

Expression of a Tn-like epitope by carcinoma cells.

1. The use of monoclonal antibodies to quantify the levels of sialoglycoproteins alpha and delta and variant sialoglycoproteins in human erythrocyte membranes.

Review 2. Human carcinoma-associated precursor antigens of the blood group MN system and the host's immune responses to them.

3. Seed agglutinin for rapid identification of Tn-polyagglutination.

4. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

5. Proposed molecular basis of murine tumor cell-hepatocyte interaction.

6. Selective deficiency of 3-beta-d-galactosyltransferase (T-transferase) in Tn-polyagglutinable erythrocytes.

7. Tn, a carcinoma-associated antigen, reacts with anti-Tn of normal human sera.

8. T and Tn, general carcinoma autoantigens.

9. Immunodot assay for determining the isotype and light chain type of murine monoclonal antibodies in unconcentrated hybridoma culture supernates.

10. Tn epitopes, immunoreactive with ordinary anti-Tn antibodies, on normal, desialylated human erythrocytes and on Thomsen-Friedenreich antigen isolated therefrom.

1. Semiquantitative immunohistochemical studies of blood group antigen A, B, H, Le(a), Le(b) structures and Ii backbone chains in the normal human cervix and in cervical adenocarcinoma.