Avi Ben-Haroush1,2, Ido Sirota1,3,4, Lina Salman1,2, Weon-Young Son5, Togas Tulandi5, Hananel Holzer5,6,7, Galia Oron8,9,10. 1. Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel. 2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 3. Department of Obstetrics and Gynecology, New York-Presbyterian/Queens, Flushing, NY, USA. 4. Weill Cornell Medicine, New York, NY, USA. 5. Department of Obstetrics and Gynecology, McGill University, Montreal, QC, Canada. 6. IVF Unit, Division of Obstetrics and Gynecology, Shaare Zedek Medical Center, Jerusalem, Israel. 7. School of Medicine, Hebrew University, Jerusalem, Israel. 8. Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel. orongalia@gmail.com. 9. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. orongalia@gmail.com. 10. Department of Obstetrics and Gynecology, McGill University, Montreal, QC, Canada. orongalia@gmail.com.
Abstract
PURPOSE: The association between obesity and reproductive outcome is controversial. The aim of this study is to evaluate the effects of obesity on clinical pregnancy rates following transfer of a single fresh embryo. METHODS: A retrospective cohort study was conducted at a single tertiary medical center, including all first, fresh, single-embryo transfers using non-donor oocytes, during 2008-2013. We compared clinical pregnancy rate and pregnancy outcomes of singleton live births resulting from the transfer of a single fresh embryo in normal weight, overweight, and obese women, defined as body mass index (BMI) < 25 kg/m2, ≥ 25 BMI <30 kg/m2, and BMI ≥ 30 kg/m2, respectively. RESULTS: Overall, 1345 cases met the inclusion criteria with 864 single-embryo transfers (SETs) in normal weight women, 292 in overweight women, and 189 SETs in obese women, resulting in 538 clinical pregnancies and 354 singleton births. The clinical pregnancy rate per transfer was similar among the three groups (41.3, 37.6, 37.5%, respectively, p = 0.416). Similarly, there were no significant differences in live births or ongoing pregnancies. On multivariate logistic regression analysis, BMI did not impact the likelihood for clinical pregnancy (OR 0.98, 95% CI 0.96-1.008, p = 0.216). CONCLUSIONS: Our study demonstrated that obesity has no detrimental effect on the clinical pregnancy rate resulting from the transfer of a single fresh embryo.
PURPOSE: The association between obesity and reproductive outcome is controversial. The aim of this study is to evaluate the effects of obesity on clinical pregnancy rates following transfer of a single fresh embryo. METHODS: A retrospective cohort study was conducted at a single tertiary medical center, including all first, fresh, single-embryo transfers using non-donor oocytes, during 2008-2013. We compared clinical pregnancy rate and pregnancy outcomes of singleton live births resulting from the transfer of a single fresh embryo in normal weight, overweight, and obesewomen, defined as body mass index (BMI) < 25 kg/m2, ≥ 25 BMI <30 kg/m2, and BMI ≥ 30 kg/m2, respectively. RESULTS: Overall, 1345 cases met the inclusion criteria with 864 single-embryo transfers (SETs) in normal weight women, 292 in overweight women, and 189 SETs in obesewomen, resulting in 538 clinical pregnancies and 354 singleton births. The clinical pregnancy rate per transfer was similar among the three groups (41.3, 37.6, 37.5%, respectively, p = 0.416). Similarly, there were no significant differences in live births or ongoing pregnancies. On multivariate logistic regression analysis, BMI did not impact the likelihood for clinical pregnancy (OR 0.98, 95% CI 0.96-1.008, p = 0.216). CONCLUSIONS: Our study demonstrated that obesity has no detrimental effect on the clinical pregnancy rate resulting from the transfer of a single fresh embryo.
Entities:
Keywords:
In vitro fertilization; Obesity; Pregnancy complications; Single-embryo transfer
Authors: John C Dumoulin; Jolande A Land; Aafke P Van Montfoort; Ewka C Nelissen; Edith Coonen; Josien G Derhaag; Inge L Schreurs; Gerard A Dunselman; Arnold D Kester; Joep P Geraedts; Johannes L Evers Journal: Hum Reprod Date: 2010-01-18 Impact factor: 6.918
Authors: José Bellver; Antonio Pellicer; Juan Antonio García-Velasco; Agustín Ballesteros; José Remohí; Marcos Meseguer Journal: Fertil Steril Date: 2013-07-03 Impact factor: 7.329
Authors: Phillip A Romanski; Pietro Bortoletto; Brady Magaoay; Alice Chung; Zev Rosenwaks; Steven D Spandorfer Journal: J Assist Reprod Genet Date: 2020-11-16 Impact factor: 3.412