OBJECTIVE: To analyze the reproductive outcome of recipients of donated ova according to their body mass index (BMI). DESIGN: Twelve-year retrospective cohort analysis. SETTING: Fertility clinics. PATIENT(S): 9,587 first cycles of ovum donation with ova from normoweight donors. INTERVENTION(S): Recipients divided according to their BMI to analyze IVF laboratory and outcome parameters: lean with BMI <20 kg/m(2) (n = 1,458; 15.2%); normoweight with BMI 20-24.9 kg/m(2) (n = 5,706; 59.5%), overweight with BMI 25-29.9 kg/m(2) (n = 1,770; 18.5%), and obese with BMI ≥30 kg/m(2) (n = 653; 6.8%). MAIN OUTCOME MEASURE(S): Implantation, biochemical and clinical pregnancy, miscarriage, and live-birth rates. RESULT(S): In vitro fertilization laboratory parameters did not differ according to BMI. However, implantation, pregnancy, clinical pregnancy, twin pregnancy, and live-birth rates were significantly reduced as BMI increased. In the lean, normoweight, overweight, and obese groups, the implantation rate was 40.4%, 39.9%, 38.5%, and 30.9%, clinical pregnancy rate was 56.9%, 55.9%, 54.3%, and 45.3%, and live-birth rate was 38.6%, 37.9%, 34.9%, and 27.7%, respectively. However, clinical miscarriage rates were similar in all the groups. CONCLUSION(S): Female obesity impairs the reproductive outcome of ovum donation probably as a result of reduced uterine receptivity.
OBJECTIVE: To analyze the reproductive outcome of recipients of donated ova according to their body mass index (BMI). DESIGN: Twelve-year retrospective cohort analysis. SETTING: Fertility clinics. PATIENT(S): 9,587 first cycles of ovum donation with ova from normoweight donors. INTERVENTION(S): Recipients divided according to their BMI to analyze IVF laboratory and outcome parameters: lean with BMI <20 kg/m(2) (n = 1,458; 15.2%); normoweight with BMI 20-24.9 kg/m(2) (n = 5,706; 59.5%), overweight with BMI 25-29.9 kg/m(2) (n = 1,770; 18.5%), and obese with BMI ≥30 kg/m(2) (n = 653; 6.8%). MAIN OUTCOME MEASURE(S): Implantation, biochemical and clinical pregnancy, miscarriage, and live-birth rates. RESULT(S): In vitro fertilization laboratory parameters did not differ according to BMI. However, implantation, pregnancy, clinical pregnancy, twin pregnancy, and live-birth rates were significantly reduced as BMI increased. In the lean, normoweight, overweight, and obese groups, the implantation rate was 40.4%, 39.9%, 38.5%, and 30.9%, clinical pregnancy rate was 56.9%, 55.9%, 54.3%, and 45.3%, and live-birth rate was 38.6%, 37.9%, 34.9%, and 27.7%, respectively. However, clinical miscarriage rates were similar in all the groups. CONCLUSION(S): Female obesity impairs the reproductive outcome of ovum donation probably as a result of reduced uterine receptivity.
Authors: Silvia Gamundi-Segura; Jose Serna; Sergio Oehninger; Jose A Horcajadas; Jose M Arbones-Mainar Journal: J Physiol Biochem Date: 2015-02-17 Impact factor: 4.158
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