Eleni A Greenwood1, Lauri A Pasch2, Jordan Hastie3, Marcelle I Cedars2, Heather G Huddleston2. 1. Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California. Electronic address: eleni.greenwood@ucsf.edu. 2. Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California. 3. University of California San Francisco School of Medicine, San Francisco, California.
Abstract
OBJECTIVE: To characterize the degree of decision regret following elective oocyte cryopreservation (EOC) for social indications, and identify factors associated with regret. DESIGN: Retrospective cohort survey study. SETTING: Academic center. PATIENTS: Two hundred one women who underwent EOC for fertility preservation between 2012 and 2016. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Decision Regret Scale (DRS) score, from 0-100, with a cut-off >25 indicative of moderate to severe regret; and attitudes regarding decision satisfaction. RESULTS: Median DRS score was 0 (interquartile range 0-15) and the mean was 10 (range 0-90). Thirty-three women (16%) experienced moderate to severe decision regret. Factors associated with decision regret included: number of eggs frozen, perceived adequacy of information prior to EOC, adequacy of emotional support during EOC, and patient-estimated probability of achieving a live birth using their banked eggs. In a multivariate logistic model, increased perceived adequacy of information (adjusted odds ratio 0.63, 95% confidence interval 0.42-0.97) and patient-estimated probability of achieving a live birth (adjusted odds ratio 0.80, 95% confidence interval 0.67-0.96) were associated with reduced odds of regret. One hundred sixty-seven women (88%) reported increased control over reproductive planning following EOC. One hundred eighty-three (89%) affirmed they will be happy they froze eggs, even if they never use them. CONCLUSIONS: The risk of decision regret following EOC is non-negligible. Low number of mature oocytes cryopreserved is a risk factor for increased regret, while perceptions of adequate information and emotional support, and increased patient-estimates of achieving a live birth using banked eggs are associated with reduced risk of regret.
OBJECTIVE: To characterize the degree of decision regret following elective oocyte cryopreservation (EOC) for social indications, and identify factors associated with regret. DESIGN: Retrospective cohort survey study. SETTING: Academic center. PATIENTS: Two hundred one women who underwent EOC for fertility preservation between 2012 and 2016. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Decision Regret Scale (DRS) score, from 0-100, with a cut-off >25 indicative of moderate to severe regret; and attitudes regarding decision satisfaction. RESULTS: Median DRS score was 0 (interquartile range 0-15) and the mean was 10 (range 0-90). Thirty-three women (16%) experienced moderate to severe decision regret. Factors associated with decision regret included: number of eggs frozen, perceived adequacy of information prior to EOC, adequacy of emotional support during EOC, and patient-estimated probability of achieving a live birth using their banked eggs. In a multivariate logistic model, increased perceived adequacy of information (adjusted odds ratio 0.63, 95% confidence interval 0.42-0.97) and patient-estimated probability of achieving a live birth (adjusted odds ratio 0.80, 95% confidence interval 0.67-0.96) were associated with reduced odds of regret. One hundred sixty-seven women (88%) reported increased control over reproductive planning following EOC. One hundred eighty-three (89%) affirmed they will be happy they froze eggs, even if they never use them. CONCLUSIONS: The risk of decision regret following EOC is non-negligible. Low number of mature oocytes cryopreserved is a risk factor for increased regret, while perceptions of adequate information and emotional support, and increased patient-estimates of achieving a live birth using banked eggs are associated with reduced risk of regret.
Authors: Sarah S Lee; Megan Sutter; Shelley Lee; Mindy R Schiffman; Yael G Kramer; David H McCulloh; Frederick Licciardi Journal: J Assist Reprod Genet Date: 2020-08-13 Impact factor: 3.412
Authors: M C Inhorn; D Birenbaum-Carmeli; J Birger; L M Westphal; J Doyle; N Gleicher; D Meirow; M Dirnfeld; D Seidman; A Kahane; P Patrizio Journal: Reprod Biol Endocrinol Date: 2018-07-23 Impact factor: 4.982