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Literature DB >> 29804214

Pseudoprogression successfully treated with bevacizumab in a child with spinal pilocytic astrocytoma.

Kenji Miyata¹, Toshinori Hori², Yasuto Shimomura², Masahiro Joko³, Masakazu Takayasu³, Akihisa Okumura².

Abstract

CLINICAL CASE: We report on a 7-year-old female with spinal pilocytic astrocytoma complicated by pseudoprogression 1 month after completion of radiation therapy. Although she was initially treated with high-dose steroids, her clinical symptoms did not completely resolve, and magnetic resonance imaging (MRI) revealed extension of the lesions into the medulla oblongata. Treatment with bevacizumab was commenced, followed by rapid resolution of the clinical symptoms and improvements in the MRI findings.
CONCLUSION: This case highlights the efficacy and tolerability of bevacizumab for the treatment of pseudoprogression in children with spinal low-grade gliomas.

Entities: Chemical Disease Species

Keywords: Bevacizumab; Pilocytic astrocytoma; Pseudoprogression; Steroid; Vascular endothelial growth factor

Mesh：

Substances：

Year: 2018 PMID： 29804214 DOI： 10.1007/s00381-018-3841-7

Source DB: PubMed Journal: Childs Nerv Syst ISSN： 0256-7040 Impact factor: 1.475

14 in total

1. Spinal cord pilocytic astrocytoma with cranial meningeal metastases.

Authors: H K Ng; C H Leung; R Boet; W S Poon
Journal: J Clin Neurosci Date: 2001-07 Impact factor: 1.961

Review 2. Effects of radiation on cerebral vasculature: a review.

Authors: M M O'Connor; M R Mayberg
Journal: Neurosurgery Date: 2000-01 Impact factor: 4.654

3. Bevacizumab for symptomatic radiation-induced tumor enlargement in pediatric low grade gliomas.

Authors: Kimberly A Foster; William J Ares; Ian F Pollack; Regina I Jakacki
Journal: Pediatr Blood Cancer Date: 2014-11-08 Impact factor: 3.167

4. Spurious progression in pediatric brain tumors.

Authors: Sheema Chawla; David N Korones; Michael T Milano; Ali Hussain; Abdel R Hussien; Ann G Muhs; Manisha Mangla; Howard Silberstein; Sven Ekholm; Louis S Constine
Journal: J Neurooncol Date: 2012-01-12 Impact factor: 4.130

5. Upregulation of vascular endothelial growth factor is associated with radiation-induced blood-spinal cord barrier breakdown.

Authors: M N Tsao; Y Q Li; G Lu; Y Xu; C S Wong
Journal: J Neuropathol Exp Neurol Date: 1999-10 Impact factor: 3.685

Review 2. Rescue bevacizumab following symptomatic pseudoprogression of a tectal glioma post-radiotherapy: a case report and review of the literature.

Authors: Timothy K Nguyen; James Perry; Arun N E Sundaram; Jay Detsky; Pejman J Maralani; Eirena Calabrese; Sunit Das; Arjun Sahgal
Journal: J Neurooncol Date: 2019-05-03 Impact factor: 4.130

2 in total

Pseudoprogression successfully treated with bevacizumab in a child with spinal pilocytic astrocytoma.

1. Spinal cord pilocytic astrocytoma with cranial meningeal metastases.

Review 2. Effects of radiation on cerebral vasculature: a review.

3. Bevacizumab for symptomatic radiation-induced tumor enlargement in pediatric low grade gliomas.

4. Spurious progression in pediatric brain tumors.

5. Upregulation of vascular endothelial growth factor is associated with radiation-induced blood-spinal cord barrier breakdown.

6. Adult intramedullary spinal cord ependymomas: the result of surgery in 38 patients.

7. Mortality is higher in patients with leptomeningeal metastasis in spinal cord tumors.

8. Pseudoprogression of low-grade gliomas after radiotherapy.

9. Phase II trial of conformal radiation therapy for pediatric low-grade glioma.

10. Cerebral radiation necrosis in pediatric patients.

1. Primary spinal pilocytic astrocytoma: clinical study with long-term follow-up in 16 patients and a literature review.

Review 2. Rescue bevacizumab following symptomatic pseudoprogression of a tectal glioma post-radiotherapy: a case report and review of the literature.