Literature DB >> 23288021

Mortality is higher in patients with leptomeningeal metastasis in spinal cord tumors.

Ricardo de Amoreira Gepp1, José Mauro Cardoso Couto, Maria Dorvalina da Silva, Marco Rolando Sainz Quiroga.   

Abstract

UNLABELLED: Spinal cord tumors are a rare neoplasm of the central nervous system (CNS). The occurrence of metastases is related to poor prognosis. The authors analyzed one series of metastasis cases and their associated mortality.
METHODS: Clinical characteristics were studied in six patients with intramedullary tumors with metastases in a series of 71 surgical cases.
RESULTS: Five patients had ependymomas of which two were WHO grade III. The patient with astrocytoma had a grade II histopathological classification. Two patients required shunts for hydrocephalus. The survival curve showed a higher mortality than the general group of patients with no metastases in the CNS (p<0.0001).
CONCLUSION: Mortality is elevated in patients with metastasis and greater than in patients with only primary lesions. The ependymomas, regardless of their degree of anaplasia, are more likely to cause metastasis than spinal cord astrocytomas.

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Year:  2013        PMID: 23288021     DOI: 10.1590/s0004-282x2012005000019

Source DB:  PubMed          Journal:  Arq Neuropsiquiatr        ISSN: 0004-282X            Impact factor:   1.420


  1 in total

1.  Pseudoprogression successfully treated with bevacizumab in a child with spinal pilocytic astrocytoma.

Authors:  Kenji Miyata; Toshinori Hori; Yasuto Shimomura; Masahiro Joko; Masakazu Takayasu; Akihisa Okumura
Journal:  Childs Nerv Syst       Date:  2018-05-27       Impact factor: 1.475

  1 in total

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