Markus Donix1, Robert Haussmann2, Franziska Helling2, Anne Zweiniger2, Jan Lange2, Annett Werner3, Katharina L Donix2, Moritz D Brandt4, Jennifer Linn5, Michael Bauer2, Maria Buthut6. 1. Department of Psychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany; German Center for Neurodegenerative Diseases (DZNE), 01307 Dresden, Germany. Electronic address: markus.donix@uniklinikum-dresden.de. 2. Department of Psychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany. 3. Department of Neuroradiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany; German Center for Neurodegenerative Diseases (DZNE), 01307 Dresden, Germany. 4. Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany; German Center for Neurodegenerative Diseases (DZNE), 01307 Dresden, Germany. 5. Department of Neuroradiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany. 6. Department of Psychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany; Department of Neurology (Neustadt/Trachau), Städtisches Klinikum Dresden, Industriestr. 40, 01129 Dresden, Germany.
Abstract
BACKGROUND: Cognitive deficits are common in patients with a depressive episode although the predictors for their development and severity remain elusive. We investigated whether subjective and objective cognitive impairment in young depressed adults would be associated with cortical thinning in medial temporal subregions. METHODS: High-resolution magnetic resonance imaging, cortical unfolding data analysis, and comprehensive assessments of subjective and objective cognitive abilities were performed on 27 young patients with a depressive episode (mean age: 29.0 ± 5.8 years) and 23 older participants without a history of a depressive disorder but amnestic mild cognitive impairment (68.5 ± 6.6 years) or normal cognition (65.2 ± 8.7 years). RESULTS: Thickness reductions in parahippocampal, perirhinal and fusiform cortices were associated with subjective memory deficits only among young patients with a depressive episode and a measurable cognitive impairment. LIMITATIONS: Long-term longitudinal data would be desirable to determine the trajectories of cognitive impairment associated with depression in patients with or without cortical structure changes. CONCLUSIONS: The presence of clinically significant cognitive deficits in young people with a depressive episode may identify a patient population with extrahippocampal cortical thinning.
BACKGROUND:Cognitive deficits are common in patients with a depressive episode although the predictors for their development and severity remain elusive. We investigated whether subjective and objective cognitive impairment in young depressed adults would be associated with cortical thinning in medial temporal subregions. METHODS: High-resolution magnetic resonance imaging, cortical unfolding data analysis, and comprehensive assessments of subjective and objective cognitive abilities were performed on 27 young patients with a depressive episode (mean age: 29.0 ± 5.8 years) and 23 older participants without a history of a depressive disorder but amnestic mild cognitive impairment (68.5 ± 6.6 years) or normal cognition (65.2 ± 8.7 years). RESULTS: Thickness reductions in parahippocampal, perirhinal and fusiform cortices were associated with subjective memory deficits only among young patients with a depressive episode and a measurable cognitive impairment. LIMITATIONS: Long-term longitudinal data would be desirable to determine the trajectories of cognitive impairment associated with depression in patients with or without cortical structure changes. CONCLUSIONS: The presence of clinically significant cognitive deficits in young people with a depressive episode may identify a patient population with extrahippocampal cortical thinning.
Authors: Mateus Henrique Nogueira; Luciana Ramalho Pimentel da Silva; José Carlos Vasques Moreira; Thiago Junqueira Ribeiro de Rezende; Tamires Araújo Zanão; Brunno Machado de Campos; Clarissa Lin Yasuda; Fernando Cendes Journal: Front Neurol Date: 2020-01-17 Impact factor: 4.003
Authors: Katrin Müller; Stephanie Fröhlich; Andresa M C Germano; Jyothsna Kondragunta; Maria Fernanda Del Carmen Agoitia Hurtado; Julian Rudisch; Daniel Schmidt; Gangolf Hirtz; Peter Stollmann; Claudia Voelcker-Rehage Journal: BMC Neurol Date: 2020-03-07 Impact factor: 2.474