Quin E Denfeld1, James O Mudd2, Wohaib Hasan3, Jill M Gelow2, Shirin O Hiatt4, Kerri Winters-Stone5, Christopher S Lee6. 1. Oregon Health & Science University School of Nursing, Portland, OR, USA. Electronic address: denfeldq@ohsu.edu. 2. Oregon Health & Science University Knight Cardiovascular Institute, Portland, OR, USA. 3. Cedars-Sinai Medical Center, West Hollywood, CA, USA. 4. Oregon Health & Science University School of Nursing, Portland, OR, USA. 5. Oregon Health & Science University School of Nursing, Portland, OR, USA; Oregon Health & Science University Knight Cancer Institute, Portland, OR, USA. 6. Boston College William F. Connell School of Nursing, Chestnut Hill, MA, USA.
Abstract
BACKGROUND: The relationship between physical heart failure (HF) symptoms and pathophysiological mechanisms is unclear. OBJECTIVE: To quantify the relationship between plasma β-adrenergic receptor kinase-1 (βARK1) and physical symptoms among adults with HF. METHODS: We performed a secondary analysis of data collected from two studies of adults with HF. Plasma βARK1 was quantified using an enzyme-linked immunosorbent assay. Physical symptoms were measured with the HF Somatic Perception Scale (HFSPS). Generalized linear modeling was used to quantify the relationship between βARK1 and HFSPS scores. RESULTS: The average age (n = 94) was 54.5 ± 13.1 years, 76.6% were male, and a majority (83.0%) had Class III or IV HF. βARK1 was significantly associated with HFSPS scores (β = 0.22 ± 0.10, p = 0.038), adjusting for other predictors of physical symptoms (model R2 = 0.250, F(7, 70) = 3.34, p = 0.004). CONCLUSIONS: Higher βARK1 is associated with worse physical HF symptoms, pinpointing a potential pathophysiologic underpinning.
BACKGROUND: The relationship between physical heart failure (HF) symptoms and pathophysiological mechanisms is unclear. OBJECTIVE: To quantify the relationship between plasma β-adrenergic receptor kinase-1 (βARK1) and physical symptoms among adults with HF. METHODS: We performed a secondary analysis of data collected from two studies of adults with HF. Plasma βARK1 was quantified using an enzyme-linked immunosorbent assay. Physical symptoms were measured with the HF Somatic Perception Scale (HFSPS). Generalized linear modeling was used to quantify the relationship between βARK1 and HFSPS scores. RESULTS: The average age (n = 94) was 54.5 ± 13.1 years, 76.6% were male, and a majority (83.0%) had Class III or IV HF. βARK1 was significantly associated with HFSPS scores (β = 0.22 ± 0.10, p = 0.038), adjusting for other predictors of physical symptoms (model R2 = 0.250, F(7, 70) = 3.34, p = 0.004). CONCLUSIONS: Higher βARK1 is associated with worse physical HF symptoms, pinpointing a potential pathophysiologic underpinning.
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