Feiby L Nassan1, Jorge E Chavarro2, Lidia Mínguez-Alarcón3, Paige L Williams4, Cigdem Tanrikut5, Jennifer B Ford3, Ramace Dadd3, Melissa J Perry6, Russ Hauser7, Audrey J Gaskins8. 1. Departments of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, United States; Departments of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, United States. Electronic address: fen769@mail.harvard.edu. 2. Departments of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, United States; Departments of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, United States; Channing Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, United States. 3. Departments of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, United States. 4. Departments of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, United States; Departments of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, United States. 5. Department of Urology, Massachusetts General Hospital, Boston, MA, United States. 6. Department of Environmental and Occupational Health, Milken Institute School of Public Health, George Washington University, Washington, DC, United States. 7. Departments of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, United States; Departments of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, United States; Vincent Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States. 8. Departments of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, United States; Channing Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, United States.
Abstract
OBJECTIVE: We examined associations of residential distance to major roadways, as a proxy for traffic-related air pollution exposures, with sperm characteristics and male reproductive hormones. DESIGN: The cohort included 797 men recruited from Massachusetts General Hospital Fertility Center between 2000 and 2015 to participate in fertility research studies. MATERIALS AND METHODS: Men reported their residential addresses at enrollment and provided 1-6 semen samples and a blood sample during follow-up. We estimated the Euclidean distance to major roadways (e.g. interstates and highways: limited access highways, multi-lane highways (not limited access), other numbered routes, and major roads) using information from the Massachusetts Department of Geographic Information Systems. Semen parameters (1238 semen samples), sperm DNA integrity (389 semen samples), chromosomal disomy (101 semen samples), and serum reproductive hormones (405 serum samples) were assessed following standard procedures. RESULTS: Men in this cohort were primarily Caucasian (86%), not current smokers (92%), with a college or higher education (88%), and had an average age of 36 years and BMI of 27.7 kg/m2. The median (interquartile range) residential distance to a major roadway was 111 (37, 248) meters. Residential proximity to major roadways was not associated with semen parameters, sperm DNA integrity, chromosomal disomy, or serum reproductive hormone concentrations. The adjusted percent change (95% CI) in semen quality parameters associated with a 500 m increase in residential distance to a major roadway was -1.0% (-6.3, 4.5) for semen volume, 4.3% (-5.8, 15.7) for sperm concentration, 3.1% (-7.2, 14.5) for sperm count, 1.1% (-1.2, 3.4) for % total motile sperm, and 0.1% (-0.3, 0.5) for % morphologically normal sperm. Results were consistent when we modeled the semen parameters dichotomized according to WHO 2010 reference values. CONCLUSION: Residential distance to major roadways, as a proxy for traffic-related air pollution exposure, was not related to sperm characteristics or serum reproductive hormones among men attending a fertility clinic in Massachusetts.
OBJECTIVE: We examined associations of residential distance to major roadways, as a proxy for traffic-related air pollution exposures, with sperm characteristics and male reproductive hormones. DESIGN: The cohort included 797 men recruited from Massachusetts General Hospital Fertility Center between 2000 and 2015 to participate in fertility research studies. MATERIALS AND METHODS:Men reported their residential addresses at enrollment and provided 1-6 semen samples and a blood sample during follow-up. We estimated the Euclidean distance to major roadways (e.g. interstates and highways: limited access highways, multi-lane highways (not limited access), other numbered routes, and major roads) using information from the Massachusetts Department of Geographic Information Systems. Semen parameters (1238 semen samples), sperm DNA integrity (389 semen samples), chromosomal disomy (101 semen samples), and serum reproductive hormones (405 serum samples) were assessed following standard procedures. RESULTS:Men in this cohort were primarily Caucasian (86%), not current smokers (92%), with a college or higher education (88%), and had an average age of 36 years and BMI of 27.7 kg/m2. The median (interquartile range) residential distance to a major roadway was 111 (37, 248) meters. Residential proximity to major roadways was not associated with semen parameters, sperm DNA integrity, chromosomal disomy, or serum reproductive hormone concentrations. The adjusted percent change (95% CI) in semen quality parameters associated with a 500 m increase in residential distance to a major roadway was -1.0% (-6.3, 4.5) for semen volume, 4.3% (-5.8, 15.7) for sperm concentration, 3.1% (-7.2, 14.5) for sperm count, 1.1% (-1.2, 3.4) for % total motile sperm, and 0.1% (-0.3, 0.5) for % morphologically normal sperm. Results were consistent when we modeled the semen parameters dichotomized according to WHO 2010 reference values. CONCLUSION: Residential distance to major roadways, as a proxy for traffic-related air pollution exposure, was not related to sperm characteristics or serum reproductive hormones among men attending a fertility clinic in Massachusetts.
Authors: N Tsukue; N Toda; H Tsubone; M Sagai; W Z Jin; G Watanabe; K Taya; J Birumachi; A K Suzuki Journal: J Toxicol Environ Health A Date: 2001-05-25
Authors: Feiby L Nassan; Brent A Coull; Niels E Skakkebaek; Michelle A Williams; Ramace Dadd; Lidia Mínguez-Alarcón; Stephen A Krawetz; Elizabeth J Hait; Joshua R Korzenik; Alan C Moss; Jennifer B Ford; Russ Hauser Journal: Environ Int Date: 2016-08-26 Impact factor: 9.621
Authors: Ming Ding; Yang Hu; Joel Schwartz; Woon-Puay Koh; Jian-Min Yuan; Howard D Sesso; Jing Ma; Jorge Chavarro; Frank B Hu; An Pan Journal: Ann Epidemiol Date: 2016-08-30 Impact factor: 3.797
Authors: S G Selevan; L Borkovec; V L Slott; Z Zudová; J Rubes; D P Evenson; S D Perreault Journal: Environ Health Perspect Date: 2000-09 Impact factor: 9.031
Authors: Kirsten S Dorans; Elissa H Wilker; Wenyuan Li; Mary B Rice; Petter L Ljungman; Joel Schwartz; Brent A Coull; Itai Kloog; Petros Koutrakis; Ralph B D'Agostino; Joseph M Massaro; Udo Hoffmann; Christopher J O'Donnell; Murray A Mittleman Journal: BMJ Open Date: 2017-03-16 Impact factor: 2.692