Ming Ding1, Yang Hu2, Joel Schwartz3, Woon-Puay Koh4, Jian-Min Yuan5, Howard D Sesso6, Jing Ma7, Jorge Chavarro8, Frank B Hu8, An Pan9. 1. Department of Nutrition, Harvard School of Public Health, Boston, MA; Department of Epidemiology, Harvard School of Public Health, Boston, MA. Electronic address: mid829@mail.harvard.edu. 2. Department of Nutrition, Harvard School of Public Health, Boston, MA. 3. Department of Epidemiology, Harvard School of Public Health, Boston, MA; Department of Environmental Health, Harvard School of Public Health, Boston, MA. 4. Duke-NUS Medical School, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore. 5. Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA; Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh. 6. Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA. 7. Department of Epidemiology, Harvard School of Public Health, Boston, MA; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA. 8. Department of Nutrition, Harvard School of Public Health, Boston, MA; Department of Epidemiology, Harvard School of Public Health, Boston, MA; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA. 9. Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Abstract
PURPOSE: Few studies have delineated body mass index (BMI) trajectories that associate with premature mortality, which is defined as death occurring before age 75 years. METHODS: We used generalized additive mixed model to identify BMI trajectories of individuals dying before or after age 75 years among 14,172 U.S. men. We used logistic regression to validate whether the BMI trajectory developed predicted mortality in an independent cohort of 7000 participants. RESULTS: Comparing to participants with age at death less than 75 years, the BMI among participants with age at death 75 years or more was lower throughout adulthood, and the mean BMI was 23.98, 24.63, 25.33, and 25.29 kg/m2 at age 40, 50, 60, and 70 years. In the validation cohort, participants following the BMI trajectory with age at death less than 75 years had higher risks of total mortality (odds ratio: 1.35; 95% confidence interval: 1.01-1.78) and cardiovascular disease mortality (1.92; 1.10-3.35) compared to participants following the trajectory with age at death 75 years or more. Participants whose BMI trajectories diverged the most from the trajectory with age at death 75 years or more had highest risks of total mortality (1.72; 1.23-2.40) and cardiovascular disease mortality (3.06; 1.49-6.30). CONCLUSIONS: Individual is suggested to maintain a normal BMI throughout adulthood to have greater longevity.
PURPOSE: Few studies have delineated body mass index (BMI) trajectories that associate with premature mortality, which is defined as death occurring before age 75 years. METHODS: We used generalized additive mixed model to identify BMI trajectories of individuals dying before or after age 75 years among 14,172 U.S. men. We used logistic regression to validate whether the BMI trajectory developed predicted mortality in an independent cohort of 7000 participants. RESULTS: Comparing to participants with age at death less than 75 years, the BMI among participants with age at death 75 years or more was lower throughout adulthood, and the mean BMI was 23.98, 24.63, 25.33, and 25.29 kg/m2 at age 40, 50, 60, and 70 years. In the validation cohort, participants following the BMI trajectory with age at death less than 75 years had higher risks of total mortality (odds ratio: 1.35; 95% confidence interval: 1.01-1.78) and cardiovascular disease mortality (1.92; 1.10-3.35) compared to participants following the trajectory with age at death 75 years or more. Participants whose BMI trajectories diverged the most from the trajectory with age at death 75 years or more had highest risks of total mortality (1.72; 1.23-2.40) and cardiovascular disease mortality (3.06; 1.49-6.30). CONCLUSIONS: Individual is suggested to maintain a normal BMI throughout adulthood to have greater longevity.
Authors: Feiby L Nassan; Jorge E Chavarro; Lidia Mínguez-Alarcón; Paige L Williams; Cigdem Tanrikut; Jennifer B Ford; Ramace Dadd; Melissa J Perry; Russ Hauser; Audrey J Gaskins Journal: Int J Hyg Environ Health Date: 2018-05-22 Impact factor: 5.840
Authors: Rebeccah L Sokol; Susan T Ennett; Meghan E Shanahan; Nisha C Gottfredson; Jennifer M Poti; Carolyn T Halpern; Edwin B Fisher Journal: Child Abuse Negl Date: 2019-07-16
Authors: Rebeccah L Sokol; Nisha C Gottfredson; Jennifer M Poti; Carolyn T Halpern; Meghan E Shanahan; Edwin B Fisher; Susan T Ennett Journal: Int J Obes (Lond) Date: 2018-09-11 Impact factor: 5.095